Anaesthetic Agents in Trauma Management
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Questions and Answers

What is a primary benefit of using Ketamine as an anaesthetic drug?

  • Antiemetic properties
  • Rapid onset/recovery
  • Vasodilation effects
  • Analgesic properties (correct)

What is a common side effect of Ketamine that users should be cautious about?

  • Hypotension
  • Tachycardia (correct)
  • Decreased sensitivity
  • Seizures

What is the purpose of supplementing Ketamine with fentanyl or morphine during anaesthesia?

  • To improve induction dosing
  • To mitigate hypertension and tachycardia (correct)
  • To enhance rapid recovery
  • To provide analgesic properties

Which of the following is a key characteristic of Propofol?

<p>It has a rapid onset and recovery (A)</p> Signup and view all the answers

What combination is referred to as Ketofol?

<p>Ketamine and Propofol (D)</p> Signup and view all the answers

What is a significant disadvantage of using thiopentone?

<p>It may lead to vasodilation and hypotension. (C)</p> Signup and view all the answers

Which of the following agents is specifically noted for causing muscle rigidity when administered in high doses?

<p>Fentanyl (A)</p> Signup and view all the answers

For which of the following agents is there a risk of hyperkalaemia?

<p>Suxamethonium (B)</p> Signup and view all the answers

What is a noted concern with the use of morphine/midazolam infusion?

<p>It leads to potential opioid tolerance requiring very high doses. (D)</p> Signup and view all the answers

What is the initial dosing recommendation for fentanyl in an infusion?

<p>5 ml/hr (C)</p> Signup and view all the answers

What is a significant risk of administering standard doses of anaesthetic agents to trauma patients?

<p>Cardiovascular collapse due to loss of sympathetic response (A)</p> Signup and view all the answers

Which anaesthetic agent is reported to have a quick onset but is also a potent vasodilator?

<p>Propofol (C)</p> Signup and view all the answers

How does ketamine differ from thiopentone and propofol in terms of analgesic properties?

<p>It provides analgesia (D)</p> Signup and view all the answers

Which paralytic is noted for being the fastest in onset and shortest in return of neuromuscular function?

<p>Suxamethonium (A)</p> Signup and view all the answers

What is the main advantage of using rocuronium in trauma care?

<p>It is useful for rapid sequence intubation and maintenance (D)</p> Signup and view all the answers

What is the most significant reason for preferring fentanyl over morphine in trauma anaesthesia?

<p>Greater potency and minor histamine release (C)</p> Signup and view all the answers

Which combination is commonly used for maintenance of balanced anaesthesia?

<p>Fentanyl combined with midazolam (B)</p> Signup and view all the answers

Why was ketamine traditionally considered contraindicated in traumatic head injuries?

<p>Due to potential raised intracranial pressure (D)</p> Signup and view all the answers

Flashcards

Ketamine induction dose

1mg/kg

Ketamine maintenance dose

1-4mg/kg/hr infusion

Ketamine benefits

Less cardiovascular risk, seizure control, analgesic & bronchodilation

Ketamine precautions

Hypertension, tachycardia, and hypersalivation

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Propofol induction dose

0.5-1mg/kg

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Propofol maintenance dose

2-4mg/kg/hr

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Propofol benefits

Rapid onset/recovery, neurological assessment, antiemetic, and seizure control

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Propofol precautions

Not analgesic and vasodilator induced hypotension

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Ketofol

Ketamine and Propofol mix

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Anaesthetic agent induction

Using reduced doses of common agents, like Propofol, Thiopentone, and Ketamine, to induce general anesthesia in trauma patients.

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Thiopentone

A quick-acting barbiturate anesthetic, but it is a vasodilator, potentially causing hypotension.

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Propofol

A GABA agent with rapid onset and recovery, potent vasodilator, and antiemetic properties.

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Ketamine

NMDA antagonist inducing dissociative anesthesia; maintains brain stem function while suppressing cortex; provides analgesia.

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Fentanyl

Preferred opioid in trauma anesthesia due to potency, short onset, minimal histamine release.

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Rocuronium

Paralytic used for rapid sequence intubation and maintenance of neuromuscular blockade in trauma.

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Suxamethonium

Fastest-acting paralytic, but with shortest return to function.

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Balanced anesthesia

Maintaining anesthesia with a combination of induction agents (e.g., Propofol) and analgesics (e.g., Fentanyl or morphine).

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Thiopentone dose

3mg/kg

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Thiopentone effect

Fastest onset, seizure control, reduces intracranial pressure

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Thiopentone precaution

Not analgesic, vasodilator=hypotension

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Fentanyl dose

1mcg/kg initial, 1-2mcg/kg/hr maintenance

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Fentanyl effect

analgesia

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Fentanyl precaution

Muscle rigidity with high-dose bolus

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Rocuronium dose

0.6-1.2 mg/kg

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Rocuronium effect

Masking of seizures

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Suxamethonium dose

1-2 mg/kg

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Thiopentone dose

3mg/kg

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Thiopentone effect

Fastest onset, seizure control, reduces intracranial pressure.

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Thiopentone precaution

Not analgesic, vasodilator causing hypotension.

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Fentanyl dose

1mcg/kg initial, 1-2mcg/kg/hr maintenance

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Fentanyl effect

Analgesia

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Fentanyl precaution

Muscle rigidity with high-dose bolus.

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Rocuronium dose

0.6-1.2 mg/kg

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Rocuronium effect

Masking of seizures

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Suxamethonium dose

1-2mg/kg

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Suxamethonium effect

Fastest acting paralytic, shortest return to function

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Morphine/midazolam infusion dose

Initial 5mls/hr and titrate as needed

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Fentanyl/midazolam infusion dose

Initial 5mls/hr and titrate as needed

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Study Notes

Anaesthetic Agents

  • Induction of general anesthesia in trauma patients often uses reduced doses of common agents, titrated to effect. Standard elective doses can cause cardiovascular collapse by removing the compensatory sympathetic response to shock.
  • Propofol, thiopentone, and ketamine are commonly used in rural Australia.
    • Thiopentone, a barbiturate, has a fast onset but can cause hypotension. It's not commonly used.
    • Propofol, a GABA agent, has a rapid onset and recovery, and antiemetic properties.
    • Ketamine, an NMDA antagonist, produces dissociative anesthesia while maintaining some brain stem function (like respiration) and provides analgesia, unlike thiopentone and propofol. Ketamine helps maintain the sympathetic response to shock. Standard doses can have a direct myocardial depressant effect, so reduced titrated doses in cases of shock are recommended. Traditional teaching considered it contraindicated in traumatic head injuries due to concerns about raised intracranial pressure, but current research shows no proof of worsening outcomes.
  • Fentanyl is the recommended opioid for trauma anesthesia due to its potency, shorter onset, and less histamine release compared to morphine.
  • Rocuronium and suxamethonium are main paralytics. Rocuronium is useful for both rapid sequence intubation and maintaining neuromuscular blockade. Suxamethonium has the fastest onset and shortest neuromuscular recovery of the two.

Maintenance of Balanced Anesthesia

  • Balanced anesthesia is typically achieved by infusing an induction agent with an analgesic (like morphine or fentanyl). Midazolam is often combined.
  • Propofol with fentanyl is another common option.
  • A ketamine infusion alone can provide balanced anesthesia, but often requires fentanyl/morphine supplementation for tachycardia and hypertension.
  • Ketofol (a ketamine/propofol mix) is another option, which combines the benefits of the two while reducing their side effects, primarily the hypotension of propofol.

Trauma Anesthesia Dosing and Maintenance Table

  • Tables provide dosing information for different drugs used in both induction and maintenance phases of anesthesia in a trauma setting, highlighting benefits and precautions. This includes drugs like Ketamine, Propofol, Thiopentone, Fentanyl, Rocuronium, and Suxamethonium. Key considerations include seizure control, analgesic effects, cardiovascular collapse risk, and recovery time, among other benefits and precautions.

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Related Documents

Anaesthetic Agents PDF

Description

Explore the use of anaesthetic agents during the induction of general anesthesia in trauma patients. This quiz covers key agents such as propofol, thiopentone, and ketamine, focusing on their effects and considerations in emergency situations. Test your knowledge on dosages, advantages, and contraindications associated with each agent.

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