Podcast
Questions and Answers
What is the main type of collagen found in fibrocartilage?
What is the main type of collagen found in fibrocartilage?
- Type 3 collagen
- Type 1 collagen (correct)
- Type 2 collagen
- Type 4 collagen
Which type of joint has hyaline articular cartilage with type 2 collagen and aggregated proteoglycans?
Which type of joint has hyaline articular cartilage with type 2 collagen and aggregated proteoglycans?
- SYN arthroses
- AMPHI arthroses (correct)
- DI arthroses
- None of the above
What is the main characteristic of diarthrodial joints?
What is the main characteristic of diarthrodial joints?
- They are found only in the axial skeleton
- They have fibrocartilage as the main component
- They have poor reparative capacity (correct)
- They are immobile joints
Which component of joints does not regenerate once worn out?
Which component of joints does not regenerate once worn out?
In which type of joint is the cartilage comprised of thin interlocking fibrous tissue?
In which type of joint is the cartilage comprised of thin interlocking fibrous tissue?
What type of mobility is characteristic of AMPHI arthroses?
What type of mobility is characteristic of AMPHI arthroses?
Which joint has fibrocartilage composed mainly of type 1 collagen?
Which joint has fibrocartilage composed mainly of type 1 collagen?
What is the main function of articular cartilage?
What is the main function of articular cartilage?
What confers deformability and the ability to distribute load in a reversible sponge-like fashion to hyaline articular cartilage?
What confers deformability and the ability to distribute load in a reversible sponge-like fashion to hyaline articular cartilage?
What gives hyaline articular cartilage its strength and structure?
What gives hyaline articular cartilage its strength and structure?
Where are the chondroitin sulfate (CS) rich region and keratan sulfate (KS) rich region located on the proteoglycan (PG) core protein?
Where are the chondroitin sulfate (CS) rich region and keratan sulfate (KS) rich region located on the proteoglycan (PG) core protein?
In osteoarthritis, what happens to the chondrocytes in hyaline articular cartilage?
In osteoarthritis, what happens to the chondrocytes in hyaline articular cartilage?
What is the main function of the hyaluronic acid binding region (HABR) in the proteoglycan (PG) monomer?
What is the main function of the hyaluronic acid binding region (HABR) in the proteoglycan (PG) monomer?
What causes joint space narrowing in arthritis?
What causes joint space narrowing in arthritis?
What is the function of aggrecan in forming proteoglycan (PG) aggregates?
What is the function of aggrecan in forming proteoglycan (PG) aggregates?
What is the main contributor to the deformability and compliance of articular cartilage?
What is the main contributor to the deformability and compliance of articular cartilage?
Which part of the proteoglycan (PG) subunit determines where and which glycosaminoglycans (GAGs) will be added on?
Which part of the proteoglycan (PG) subunit determines where and which glycosaminoglycans (GAGs) will be added on?
Which component of proteoglycans attracts water into the cartilage?
Which component of proteoglycans attracts water into the cartilage?
What happens to cartilage when there are no GAGs in proteoglycans?
What happens to cartilage when there are no GAGs in proteoglycans?
What is the consequence of breakdown of the collagen network in hyaline articular cartilage?
What is the consequence of breakdown of the collagen network in hyaline articular cartilage?
What is the function of aggrecan PG monomers in forming PG aggregates?
What is the function of aggrecan PG monomers in forming PG aggregates?
How do chondrocytes receive nutrients in hyaline articular cartilage?
How do chondrocytes receive nutrients in hyaline articular cartilage?
Which part of the proteoglycan monomer resembles a hook allowing it to bind with hyaluronic acid (HA)?
Which part of the proteoglycan monomer resembles a hook allowing it to bind with hyaluronic acid (HA)?
What is the main reason that proteoglycan (PG) aggregates are protected from enzymatic degradation?
What is the main reason that proteoglycan (PG) aggregates are protected from enzymatic degradation?
What is the role of tissue inhibitors of metalloproteases (TIMPs) in the context of osteoarthritis (OA)?
What is the role of tissue inhibitors of metalloproteases (TIMPs) in the context of osteoarthritis (OA)?
Which enzyme targets the type 2 collagen arcade in cartilage?
Which enzyme targets the type 2 collagen arcade in cartilage?
In osteoarthritis (OA), which enzyme specifically targets proteoglycans?
In osteoarthritis (OA), which enzyme specifically targets proteoglycans?
What happens to the water content in articular cartilage during late osteoarthritis?
What happens to the water content in articular cartilage during late osteoarthritis?
Which factor upregulates the production of MMP enzymes that contribute to cartilage degradation?
Which factor upregulates the production of MMP enzymes that contribute to cartilage degradation?
What is the main difference between normal chondrocytes and those in osteoarthritis (OA)?
What is the main difference between normal chondrocytes and those in osteoarthritis (OA)?
What is the main cause of the worse fragmentation of collagen arcade in osteoarthritis (OA)?
What is the main cause of the worse fragmentation of collagen arcade in osteoarthritis (OA)?
What happens to the water content in cartilage in later stages of OA?
What happens to the water content in cartilage in later stages of OA?
What is the impact of decreased proteoglycan (PG) aggregates in osteoarthritis?
What is the impact of decreased proteoglycan (PG) aggregates in osteoarthritis?
What is a notable finding common in both aging and osteoarthritis?
What is a notable finding common in both aging and osteoarthritis?
What leads to milder non-progressive fibrillation of cartilage?
What leads to milder non-progressive fibrillation of cartilage?
Which enzyme is responsible for cleaving PG aggregates in osteoarthritis?
Which enzyme is responsible for cleaving PG aggregates in osteoarthritis?
In osteoarthritis, what causes the regression of chondroitin sulfate from CS-6 to CS-4?
In osteoarthritis, what causes the regression of chondroitin sulfate from CS-6 to CS-4?
What effect does ER stress have on cartilage in aging and osteoarthritis?
What effect does ER stress have on cartilage in aging and osteoarthritis?
