Podcast
Questions and Answers
What type of collagen is the main type found in fibrocartilage?
What type of collagen is the main type found in fibrocartilage?
Which type of joint has hyaline articular cartilage that is made up of type 2 collagen?
Which type of joint has hyaline articular cartilage that is made up of type 2 collagen?
Where is fibrocartilage typically found in the body?
Where is fibrocartilage typically found in the body?
What happens to hyaline articular cartilage when it wears out?
What happens to hyaline articular cartilage when it wears out?
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Which joint type has a fibrous capsule surrounding it and is lined by synovium?
Which joint type has a fibrous capsule surrounding it and is lined by synovium?
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What protects the PG aggregates from enzymatic degradation in the collagen network?
What protects the PG aggregates from enzymatic degradation in the collagen network?
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Which enzyme targets the type 2 collagen arcade?
Which enzyme targets the type 2 collagen arcade?
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In osteoarthritis (OA), which enzymes are up-regulated and considered 'out of control'?
In osteoarthritis (OA), which enzymes are up-regulated and considered 'out of control'?
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Which enzyme targets proteoglycans in the articular cartilage?
Which enzyme targets proteoglycans in the articular cartilage?
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Which factor up-regulates MMP enzymes in osteoarthritis?
Which factor up-regulates MMP enzymes in osteoarthritis?
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What helps stimulate cartilage metabolism and synthesis?
What helps stimulate cartilage metabolism and synthesis?
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Which enzymes are considered the 'villains' in cartilage degradation?
Which enzymes are considered the 'villains' in cartilage degradation?
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Which enzymes are part of the neutral matrix metalloproteases (NMMPs)?
Which enzymes are part of the neutral matrix metalloproteases (NMMPs)?
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What is the main function of articular cartilage in joints?
What is the main function of articular cartilage in joints?
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What happens when the collagen network in hyaline articular cartilage breaks down?
What happens when the collagen network in hyaline articular cartilage breaks down?
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Which component of hyaline articular cartilage has a bottle brush configuration?
Which component of hyaline articular cartilage has a bottle brush configuration?
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Why does hyaline articular cartilage appear radiolucent on X-ray?
Why does hyaline articular cartilage appear radiolucent on X-ray?
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What is the function of type 2 collagen in hyaline articular cartilage?
What is the function of type 2 collagen in hyaline articular cartilage?
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Why is articular cartilage like a sponge in terms of water content?
Why is articular cartilage like a sponge in terms of water content?
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What happens when the hyaline articular cartilage wears out in arthritis?
What happens when the hyaline articular cartilage wears out in arthritis?
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Why do chondrocytes occupy a relatively small surface area in hyaline articular cartilage?
Why do chondrocytes occupy a relatively small surface area in hyaline articular cartilage?
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What is the role of chondrocytes in osteoarthritis?
What is the role of chondrocytes in osteoarthritis?
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Where do chondrocytes derive from?
Where do chondrocytes derive from?
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What confers the property of deformability and the ability to distribute load in a reversible sponge-like fashion in hyaline articular cartilage?
What confers the property of deformability and the ability to distribute load in a reversible sponge-like fashion in hyaline articular cartilage?
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Where is Chondroitin Sulfate (CS) mainly located in the proteoglycan core protein in adult cartilage?
Where is Chondroitin Sulfate (CS) mainly located in the proteoglycan core protein in adult cartilage?
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Which part of the proteoglycan monomer determines where and which glycosaminoglycans (GAGs) will be added on to the core?
Which part of the proteoglycan monomer determines where and which glycosaminoglycans (GAGs) will be added on to the core?
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What renders Glycosaminoglycans (GAGs) highly hydrophilic enabling hydration and deformability of the cartilage matrix?
What renders Glycosaminoglycans (GAGs) highly hydrophilic enabling hydration and deformability of the cartilage matrix?
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What is the main function of the Hyaluronic Acid Binding Region (HABR) in proteoglycan monomers?
What is the main function of the Hyaluronic Acid Binding Region (HABR) in proteoglycan monomers?
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What allows the PG monomers or aggrecans to bind to Hyaluronic Acid (HA) forming PG aggregates?
What allows the PG monomers or aggrecans to bind to Hyaluronic Acid (HA) forming PG aggregates?
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Where is Keratan Sulfate (KS) enriched in the proteoglycan core protein in relation to Chondroitin Sulfate (CS)?
Where is Keratan Sulfate (KS) enriched in the proteoglycan core protein in relation to Chondroitin Sulfate (CS)?
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What renders Glycosaminoglycans (GAGs) highly hydrophilic allowing for hydration of the cartilage matrix?
What renders Glycosaminoglycans (GAGs) highly hydrophilic allowing for hydration of the cartilage matrix?
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What contributes significantly to the molecular weight of Proteoglycan monomers?
What contributes significantly to the molecular weight of Proteoglycan monomers?
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What is the backbone of a Proteoglycan subunit?
What is the backbone of a Proteoglycan subunit?
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Which region contains the larger GAG chains in Proteoglycans of articular cartilage PGs?
Which region contains the larger GAG chains in Proteoglycans of articular cartilage PGs?
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