Podcast
Questions and Answers
What type of collagen is the main type found in fibrocartilage?
What type of collagen is the main type found in fibrocartilage?
- Type 4 collagen
- Type 3 collagen
- Type 1 collagen (correct)
- Type 2 collagen
Which type of joints have minimal mobility and contain fibrocartilage between bones?
Which type of joints have minimal mobility and contain fibrocartilage between bones?
- SYN arthroses
- AMPHI arthroses
- DI arthroses (correct)
- None of the above
What is the main type of collagen found in hyaline articular cartilage?
What is the main type of collagen found in hyaline articular cartilage?
- Type 3 collagen
- Type 4 collagen
- Type 2 collagen (correct)
- Type 1 collagen
Which type of joint is surrounded by a fibrous capsule and lined by synovium?
Which type of joint is surrounded by a fibrous capsule and lined by synovium?
What happens to hyaline articular cartilage when it wears out?
What happens to hyaline articular cartilage when it wears out?
Which joints are characterized by being mobile and occurring in peripheral limb joints and TMJ?
Which joints are characterized by being mobile and occurring in peripheral limb joints and TMJ?
The menisci of the knee are examples of which type of cartilage?
The menisci of the knee are examples of which type of cartilage?
"Today, we will focus on the 3rd type of joint" refers to which type of joint?
"Today, we will focus on the 3rd type of joint" refers to which type of joint?
What is the main role of articular cartilage in a joint?
What is the main role of articular cartilage in a joint?
What is the composition of water in normal hyaline articular cartilage?
What is the composition of water in normal hyaline articular cartilage?
In osteoarthritis, what happens to the chondrocytes in hyaline articular cartilage?
In osteoarthritis, what happens to the chondrocytes in hyaline articular cartilage?
Which component gives hyaline articular cartilage its strength and structure?
Which component gives hyaline articular cartilage its strength and structure?
What is the main function of proteoglycans in cartilage?
What is the main function of proteoglycans in cartilage?
Why does hyaline articular cartilage appear radiolucent on X-ray?
Why does hyaline articular cartilage appear radiolucent on X-ray?
What is the source of nutrients for chondrocytes in hyaline articular cartilage?
What is the source of nutrients for chondrocytes in hyaline articular cartilage?
'The hydrophilia of the cartilage proteoglycans is crucial.' What does this mean for the cartilage?
'The hydrophilia of the cartilage proteoglycans is crucial.' What does this mean for the cartilage?
What role do PG aggregates play in the articular cartilage?
What role do PG aggregates play in the articular cartilage?
Which enzyme targets type 2 collagen arcade?
Which enzyme targets type 2 collagen arcade?
What is the main role of TIMPS in the articular cartilage?
What is the main role of TIMPS in the articular cartilage?
Which enzyme is responsible for targeting proteoglycans in the articular cartilage?
Which enzyme is responsible for targeting proteoglycans in the articular cartilage?
What happens to water content in the articular cartilage during late osteoarthritis?
What happens to water content in the articular cartilage during late osteoarthritis?
What confers the property of deformability and the ability to distribute load in a reversible sponge-like fashion in hyaline articular cartilage?
What confers the property of deformability and the ability to distribute load in a reversible sponge-like fashion in hyaline articular cartilage?
Which hormone helps stimulate cartilage metabolism and synthesis?
Which hormone helps stimulate cartilage metabolism and synthesis?
What is the main factor that tips the balance toward cartilage catabolism in osteoarthritis?
What is the main factor that tips the balance toward cartilage catabolism in osteoarthritis?
Where is Chondroitin Sulfate (CS) located in the core protein of proteoglycans in articular cartilage?
Where is Chondroitin Sulfate (CS) located in the core protein of proteoglycans in articular cartilage?
What is the main function of the glycans side chains (GAGs) in proteoglycan monomers?
What is the main function of the glycans side chains (GAGs) in proteoglycan monomers?
Which enzyme targets the collagen arcade and is a collagenase?
Which enzyme targets the collagen arcade and is a collagenase?
Which region of the aggrecan PG monomer houses Keratan Sulfate (KS) chains?
Which region of the aggrecan PG monomer houses Keratan Sulfate (KS) chains?
What allows for the deformability and shock-absorbing effect of hyaline articular cartilage?
What allows for the deformability and shock-absorbing effect of hyaline articular cartilage?
What is the main role of the hook or hyaluronic acid binding region (HABR) in proteoglycan aggregates?
What is the main role of the hook or hyaluronic acid binding region (HABR) in proteoglycan aggregates?
What would be the likely effect on cartilage if it lacked glycosaminoglycans (GAGs)?
What would be the likely effect on cartilage if it lacked glycosaminoglycans (GAGs)?
What is the consequence of the up-regulation of MMP 1 and 13 in severe progressive fibrillation of cartilage?
What is the consequence of the up-regulation of MMP 1 and 13 in severe progressive fibrillation of cartilage?
What effect does the loss of cartilage PG's have on the water content in osteoarthritis (OA)?
What effect does the loss of cartilage PG's have on the water content in osteoarthritis (OA)?
What is the main reason for the decrease in tensile strength of collagen seen in OA?
What is the main reason for the decrease in tensile strength of collagen seen in OA?
What is the impact of decreased PG aggregates due to cleavage at the CS-6 hook binding region by aggrecanase?
What is the impact of decreased PG aggregates due to cleavage at the CS-6 hook binding region by aggrecanase?
What is a significant finding related to chondrocytes in aging and in OA?
What is a significant finding related to chondrocytes in aging and in OA?
