Principles of Disease II: Cancer Genetics
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Principles of Disease II: Cancer Genetics

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Questions and Answers

What type of genes regulate cell proliferation, differentiation, and survival?

  • Tumor suppressor genes
  • Genes that regulate apoptosis
  • Proto-oncogenes (correct)
  • Genes involved in DNA repair

    • What is the role of genes involved in DNA repair?

  • Maintaining genomic stability (correct)
  • Regulation of apoptosis
  • Promoting angiogenesis
  • Enhancing cellular metabolism

    • Which of the following is a hallmark of cancer?

  • Increased angiogenesis (correct)
  • Loss of cellular metabolism
  • Enhanced DNA repair
  • Programmed cell death

    • What is the result of oncogenes?

    <p>uncontrolled proliferation of cells</p> Signup and view all the answers

    What is the function of tumor suppressor genes?

    <p>Inhibiting cell growth</p> Signup and view all the answers

    Which of the following is an example of an oncogene?

    <p>HER2/NEU gene</p> Signup and view all the answers

    What is the primary characteristic of tumors?

    <p>They arise from a single progenitor cell</p> Signup and view all the answers

    What is the result of an accumulation of mutations in carcinogenesis?

    <p>A multistep process</p> Signup and view all the answers

    What is the function of tumor suppressor genes?

    <p>To inhibit cell growth</p> Signup and view all the answers

    What is the role of apoptosis genes in cancer development?

    <p>They regulate cell death</p> Signup and view all the answers

    What is the function of DNA repair genes in cancer development?

    <p>To repair DNA damage</p> Signup and view all the answers

    What is the 'two-hit' theory related to?

    <p>Tumor suppressor genes</p> Signup and view all the answers

    Which type of RAS gene is often associated with melanoma and hematopoietic tumors?

    <p>NRAS</p> Signup and view all the answers

    What is the normal function of the p53 protein?

    <p>To maintain the integrity of the genome</p> Signup and view all the answers

    What is the result of activated p53?

    <p>Temporary arrest of cell cycle at G1-S phase</p> Signup and view all the answers

    What is the requirement for RB gene inactivation in retinoblastoma?

    <p>Two mutations involving both alleles of the suppressor gene</p> Signup and view all the answers

    Which gene is associated with Burkitt lymphoma?

    <p>MYC</p> Signup and view all the answers

    What is the result of N-MYC gene amplification?

    <p>Neuroblastomas</p> Signup and view all the answers

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