18 Questions
What type of genes regulate cell proliferation, differentiation, and survival?
Proto-oncogenes
What is the role of genes involved in DNA repair?
Maintaining genomic stability
Which of the following is a hallmark of cancer?
Increased angiogenesis
What is the result of oncogenes?
uncontrolled proliferation of cells
What is the function of tumor suppressor genes?
Inhibiting cell growth
Which of the following is an example of an oncogene?
HER2/NEU gene
What is the primary characteristic of tumors?
They arise from a single progenitor cell
What is the result of an accumulation of mutations in carcinogenesis?
A multistep process
What is the function of tumor suppressor genes?
To inhibit cell growth
What is the role of apoptosis genes in cancer development?
They regulate cell death
What is the function of DNA repair genes in cancer development?
To repair DNA damage
What is the 'two-hit' theory related to?
Tumor suppressor genes
Which type of RAS gene is often associated with melanoma and hematopoietic tumors?
NRAS
What is the normal function of the p53 protein?
To maintain the integrity of the genome
What is the result of activated p53?
Temporary arrest of cell cycle at G1-S phase
What is the requirement for RB gene inactivation in retinoblastoma?
Two mutations involving both alleles of the suppressor gene
Which gene is associated with Burkitt lymphoma?
MYC
What is the result of N-MYC gene amplification?
Neuroblastomas
Test your knowledge of the principles of disease, specifically cancer genetics, including genomic instability, proto-oncogenes, tumor suppressor genes, and DNA repair. This quiz covers key concepts from Vision Colleges College of Medicine.
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