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Principles of Disease II: Cancer Genetics

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Principles of Disease II: Cancer Genetics

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Questions and Answers

What type of genes regulate cell proliferation, differentiation, and survival?

Tumor suppressor genes

Genes that regulate apoptosis

Proto-oncogenes (correct)

Genes involved in DNA repair

What is the role of genes involved in DNA repair?

Maintaining genomic stability (correct)

Regulation of apoptosis

Promoting angiogenesis

Enhancing cellular metabolism

Which of the following is a hallmark of cancer?

Increased angiogenesis (correct)

Loss of cellular metabolism

Enhanced DNA repair

Programmed cell death

What is the result of oncogenes?

uncontrolled proliferation of cells Signup and view all the answers

What is the function of tumor suppressor genes?

Inhibiting cell growth Signup and view all the answers

Which of the following is an example of an oncogene?

HER2/NEU gene Signup and view all the answers

What is the primary characteristic of tumors?

They arise from a single progenitor cell Signup and view all the answers

What is the result of an accumulation of mutations in carcinogenesis?

A multistep process Signup and view all the answers

What is the function of tumor suppressor genes?

To inhibit cell growth Signup and view all the answers

What is the role of apoptosis genes in cancer development?

They regulate cell death Signup and view all the answers

What is the function of DNA repair genes in cancer development?

To repair DNA damage Signup and view all the answers

What is the 'two-hit' theory related to?

Tumor suppressor genes Signup and view all the answers

Which type of RAS gene is often associated with melanoma and hematopoietic tumors?

NRAS Signup and view all the answers

What is the normal function of the p53 protein?

To maintain the integrity of the genome Signup and view all the answers

What is the result of activated p53?

Temporary arrest of cell cycle at G1-S phase Signup and view all the answers

What is the requirement for RB gene inactivation in retinoblastoma?

Two mutations involving both alleles of the suppressor gene Signup and view all the answers

Which gene is associated with Burkitt lymphoma?

MYC Signup and view all the answers

What is the result of N-MYC gene amplification?

Neuroblastomas Signup and view all the answers

Principles of Disease II: Cancer Genetics

Choose a study mode

Podcast

Questions and Answers

What type of genes regulate cell proliferation, differentiation, and survival?

What is the role of genes involved in DNA repair?

Which of the following is a hallmark of cancer?

What is the result of oncogenes?

What is the function of tumor suppressor genes?

Which of the following is an example of an oncogene?

What is the primary characteristic of tumors?

What is the result of an accumulation of mutations in carcinogenesis?

What is the function of tumor suppressor genes?

What is the role of apoptosis genes in cancer development?

What is the function of DNA repair genes in cancer development?

What is the 'two-hit' theory related to?

Which type of RAS gene is often associated with melanoma and hematopoietic tumors?

What is the normal function of the p53 protein?

What is the result of activated p53?

What is the requirement for RB gene inactivation in retinoblastoma?

Which gene is associated with Burkitt lymphoma?

What is the result of N-MYC gene amplification?

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