Podcast
Questions and Answers
Cancer is always caused by genetic changes that affect cell cycle control
Cancer is always caused by genetic changes that affect cell cycle control
True
Tumor-suppressor genes are responsible for stimulating the cell cycle
Tumor-suppressor genes are responsible for stimulating the cell cycle
False
Proto-oncogenes can be converted to oncogenes by amplification of the gene
Proto-oncogenes can be converted to oncogenes by amplification of the gene
True
Oncogenes are genes that prevent cancer
Oncogenes are genes that prevent cancer
Signup and view all the answers
Mutations in the p53 tumor-suppressor gene can lead to cancer
Mutations in the p53 tumor-suppressor gene can lead to cancer
Signup and view all the answers
Ras is a tumor-suppressor gene
Ras is a tumor-suppressor gene
Signup and view all the answers
The gene regulation systems involved in embryonic development are the same as those involved in cancer
The gene regulation systems involved in embryonic development are the same as those involved in cancer
Signup and view all the answers
Tumor viruses can cause cancer in animals
Tumor viruses can cause cancer in animals
Signup and view all the answers
Study Notes
Cancer and Cell Cycle Control
- Cancer results from genetic changes that affect cell cycle control
- Gene regulation systems involved in embryonic development are the same ones that go wrong during cancer
Types of Genes Associated with Cancer
- Cancer can be caused by mutations in genes that regulate cell growth and division
- Tumor viruses can cause cancer in animals, including humans
Oncogenes and Proto-Oncogenes
- Oncogenes are cancer-causing genes
- Proto-oncogenes are normal cellular genes responsible for normal cell growth and division
- Conversion of a proto-oncogene to an oncogene can lead to abnormal stimulation of the cell cycle
- Proto-oncogenes can be converted to oncogenes by:
- Movement of DNA within the genome
- Amplification of a proto-oncogene
- Point mutations in the proto-oncogene or its control elements
Tumor-Suppressor Genes
- Tumor-suppressor genes help prevent uncontrolled cell growth
- Mutations that decrease protein products of tumor-suppressor genes may contribute to cancer onset
- Tumor-suppressor proteins:
- Repair damaged DNA
- Control cell adhesion
- Inhibit the cell cycle in the cell-signaling pathway
Interference with Normal Cell-Signaling Pathways
- Mutations in the ras proto-oncogene and p53 tumor-suppressor gene are common in human cancers
- Mutations in the ras gene can lead to production of a hyperactive Ras protein and increased cell division
- Suppression of the cell cycle can be important in the case of damage to a cell's DNA; p53 prevents a cell from passing on mutations
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
This quiz covers the genetics of cancer, including the role of cell cycle control, gene regulation, and types of genes associated with cancer. It also explores oncogenes and proto-oncogenes.
