Cancer Biology and Genetics
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Questions and Answers

What is the purpose of the Oncotype Dx Prognostic Assay in breast cancer?

  • To predict the risk of recurrence in early-stage breast cancer (correct)
  • To diagnose breast cancer
  • To determine the optimal adjuvant therapy for breast cancer
  • To identify the molecular subtype of breast cancer
  • Which of the following biomarkers is used to predict survival estimates in breast cancer patients?

  • Oncotype Dx recurrence score
  • Mammaprint
  • PREDICT (correct)
  • Sorlie et al.
  • What is the primary use of the Mammaprint biomarker in breast cancer?

  • To guide chemotherapy decisions
  • To diagnose breast cancer
  • To predict the risk of recurrence in early-stage breast cancer (correct)
  • To identify the molecular subtype of breast cancer
  • What is the role of Sawyers' findings in cancer research?

    <p>To understand the molecular mechanisms of cancer development</p> Signup and view all the answers

    What is the purpose of selecting patients for chemotherapy based on DNA tests?

    <p>To reduce the risk of recurrence in cancer patients</p> Signup and view all the answers

    What is the relationship between the Oncotype Dx recurrence score and clinicopathological variables?

    <p>The recurrence score is independent of clinicopathological variables</p> Signup and view all the answers

    What is the key characteristic of a cancer genome that enables cancer progression?

    <p>Genomic variation and mutation</p> Signup and view all the answers

    Which type of cells are capable of self-renewal and proliferation, thereby forming a tumor?

    <p>Stem cells and progenitor cells</p> Signup and view all the answers

    What is the outcome of chronic irritation and exposure to DNA-damaging agents, such as PCBs and cigarette smoke condensate?

    <p>Irreversible gene and epigenetic changes</p> Signup and view all the answers

    What is the characteristic of cancer cells that allows them to evade the immune system and become immortal?

    <p>Immune evasion and immortality</p> Signup and view all the answers

    What is the result of mutations in genes involved in proliferation, apoptosis, angiogenesis, invasion, and metastasis?

    <p>Polygenic disease</p> Signup and view all the answers

    What is the outcome of the process of mutational initiation, where a normal cell becomes a cancer cell?

    <p>Integral progression of cancer</p> Signup and view all the answers

    What is the primary mechanism by which proto-oncogenes and tumor suppressor genes contribute to cancer development?

    <p>Genomic variation and mutation</p> Signup and view all the answers

    What is the estimated number of non-synonymous changes to protein-coding sequences in a typical individual compared to a reference genome?

    <p>5,000-10,000</p> Signup and view all the answers

    What is the primary goal of Genome-Wide Association Studies (GWAS) in cancer research?

    <p>Identifying genetic variants associated with cancer risk</p> Signup and view all the answers

    What type of genomic variation is typically associated with copy number changes?

    <p>Copy number variants (CNVs)</p> Signup and view all the answers

    What is the primary challenge in understanding the relationship between genotype and phenotype in cancer?

    <p>Complexity of genotype-phenotype relationships</p> Signup and view all the answers

    What is the estimated cost of the Human Genome Project, which aimed to sequence the first human genome?

    <p>$3 billion</p> Signup and view all the answers

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