Premature Infants and General Anesthesia

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Questions and Answers

The primary variables controlling pulmonary ventilation in neonates are PaO2, PaCO2, and ______

pH

Neonates have reduced PaO2 compensated by greater ______ due to increased hemoglobin concentrations

oxygen-carrying capacity

Neonatal hemoglobin content is composed of 50% fetal hemoglobin, which has a left-shifted oxygen–dissociation curve compared to ______ hemoglobin

adult

Neonatal response to hypercapnia is not potentiated by ______, and hypoxia may depress the hypercapnic ventilatory response

<p>hypoxia</p> Signup and view all the answers

Preterm infants with ______ (hematocrit < 30%) are more prone to apnea

<p>anemia</p> Signup and view all the answers

What is the main risk factor for life-threatening apnea during general anesthesia in infants?

<p>Prematurity (A)</p> Signup and view all the answers

What is the relationship between gestational age and the risk of postanesthetic respiratory depression in infants?

<p>Inversely related (D)</p> Signup and view all the answers

Up to how many weeks after conception may infants be at risk of apnea?

<p>60 weeks (C)</p> Signup and view all the answers

What is the composition of neonatal hemoglobin content at birth?

<p>100% fetal hemoglobin (A)</p> Signup and view all the answers

What happens to the oxygen–dissociation curve during the first week of life in neonates?

<p>It shifts to the right (D)</p> Signup and view all the answers

What are the primary variables controlling pulmonary ventilation in neonates?

<p>PaO2, PaCO2, and pH (D)</p> Signup and view all the answers

What is the effect of high concentrations of oxygen on neonatal respiration?

<p>Depresses it (B)</p> Signup and view all the answers

What is neonatal apnea?

<p>Cessation of breathing with associated pathophysiology (A)</p> Signup and view all the answers

What is the cause of central apnea in neonates?

<p>Immaturity or depression of the respiratory drive (D)</p> Signup and view all the answers

What is the most common morbidity associated with anesthesia in neonates?

<p>Postoperative apnea (A)</p> Signup and view all the answers

What is the incidence of postoperative apnea related to in neonates?

<p>Both gestational age and PCA (B)</p> Signup and view all the answers

What are common causes of postoperative apnea in neonates?

<p>Metabolic derangements and pharmacologic effects (A)</p> Signup and view all the answers

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