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Podcast
Podcast
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Questions and Answers
Questions and Answers
What is the result of excessively high PVR in persistent pulmonary hypertension (PPHN)?
What is the result of excessively high PVR in persistent pulmonary hypertension (PPHN)?
- Persistence of the fetal circulatory pattern of right-to-left shunting through the PDA and foramen ovale after birth (correct)
- Decreased pulmonary artery medial muscle thickness
- Reduced postnatal PaO2 levels
- Increased pulmonary hypoplasia
What is the consequence of lung inflation in reducing PVR?
What is the consequence of lung inflation in reducing PVR?
- Rapid decline in PVR (correct)
- Release of vasoactive substances
- Increase in PaCO2
- Decrease in pH
What suggests right-to-left shunting through the ductus arteriosus in PPHN?
What suggests right-to-left shunting through the ductus arteriosus in PPHN?
- Decreased pH in the right radial artery
- PaO2 or oxygen saturation gradient between a preductal and a post-ductal site of blood sampling (correct)
- PaCO2 levels in the umbilical artery
- Increased PVR in the pulmonary arterioles
What is the pathogenesis of PPHN related to chronic fetal hypoxia?
What is the pathogenesis of PPHN related to chronic fetal hypoxia?
What diagnostic tool is helpful in evaluating PPHN?
What diagnostic tool is helpful in evaluating PPHN?
Questions and Answers
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Flashcards
Flashcards
Effect of High PVR in PPHN
Effect of High PVR in PPHN
Persistence of right-to-left shunting through the PDA and foramen ovale after birth.
Consequence of Lung Inflation on PVR
Consequence of Lung Inflation on PVR
Rapid decline in PVR.
Right-to-Left Shunting Indication
Right-to-Left Shunting Indication
PaO2 or oxygen saturation gradient between preductal and post-ductal sites.
PPHN Pathogenesis: Chronic Hypoxia
PPHN Pathogenesis: Chronic Hypoxia
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Diagnostic Tool for PPHN
Diagnostic Tool for PPHN
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Flashcards
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Study Notes
Study Notes
Persistent Pulmonary Hypertension (PPHN)
- Excessive PVR consequence: Right ventricular failure that may lead to cardiovascular collapse
- Lung inflation effect: Reduces PVR by recruiting and distending lung vessels, improving oxygenation and cardiovascular stability
Ductus Arteriosus Shunting
- Right-to-left shunting indication: Presence of differential cyanosis (lower limbs more cyanosed than upper limbs)
- Ductal shunting pathophysiology: Oxygenated blood from the aorta bypasses the lungs, deoxygenated blood from the pulmonary artery flows to the descending aorta
PPHN Pathogenesis
- Chronic fetal hypoxia effect: Increases pulmonary vascular resistance, leading to PPHN
- Fetal hypoxia mechanisms: Impairs vascularization, increases smooth muscle growth, and alters vascular reactivity
PPHN Diagnosis
- Diagnostic tool: Echocardiography, which helps evaluate cardiac anatomy, right ventricular function, and pulmonary artery pressure
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