Neonatal Sepsis

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Which group of neonates is most likely to have a rapid onset of sepsis?

Premature neonates

How many newborns with early-onset sepsis present within 24 hours?

85%

How is early-onset sepsis most commonly acquired by the neonate?

Ascending infection from the cervix

Which microorganisms are most commonly associated with early-onset sepsis?

Group B Streptococcus (GBS)

What trend has been observed in the incidence of GBS disease in early-onset sepsis?

Decreasing incidence

Study Notes

Sepsis in Neonates

  • Premature neonates are most likely to have a rapid onset of sepsis
  • In early-onset sepsis, 85% of newborns present within 24 hours
  • Early-onset sepsis is most commonly acquired by the neonate via vertical transmission from the maternal genital tract
  • Group B Streptococcus (GBS) and Escherichia coli (E. coli) are the microorganisms most commonly associated with early-onset sepsis
  • There has been a decreasing trend in the incidence of GBS disease in early-onset sepsis, likely due to the increased use of intrapartum antibiotic prophylaxis

Test your knowledge on neonatal sepsis and its categorization as early or late onset. Learn about the timing of presentation, associated risk factors, and the acquisition of microorganisms in early-onset sepsis.

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