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What are the antimicrobials included in the family Polymyxins?
What are the antimicrobials included in the family Polymyxins?
Polymyxin B and Polymyxin E
What is the ranking of polymyxins according to the WHO list of medically important antimicrobials?
What is the ranking of polymyxins according to the WHO list of medically important antimicrobials?
Highest priority critically important antimicrobial
Why are polymyxins considered “last resort” antibiotics?
Why are polymyxins considered “last resort” antibiotics?
- They have a broad spectrum of activity
- They are highly effective against Gram-positive bacteria
- They are used to treat carbapenem-resistant Enterobacteriaceae (correct)
- They are commonly used as a first-line treatment for bacterial infections
Describe the absorption properties of polymyxins
Describe the absorption properties of polymyxins
What is the primary mechanism of action of polymyxins?
What is the primary mechanism of action of polymyxins?
Polymyxins effect and dependability is:
Polymyxins effect and dependability is:
Polymyxins also have the ability to bind and inactivate ________, also called endotoxin, reducing ________ and ___________ destruction
Polymyxins also have the ability to bind and inactivate ________, also called endotoxin, reducing ________ and ___________ destruction
What is a significant adverse effect associated with the parenteral administration of polymyxins?
What is a significant adverse effect associated with the parenteral administration of polymyxins?
Polymyxins spectrum of activity is broad spectrum
Polymyxins spectrum of activity is broad spectrum
In veterinary medicine, what are polymyxin B formulations commonly used for?
In veterinary medicine, what are polymyxin B formulations commonly used for?
Human intravenous formulations of polymyxin B are available
Human intravenous formulations of polymyxin B are available
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