18 Questions
What is the final step that stabilizes and cements the platelet plug to prevent dislodgment?
Activation of Factor XIII
Which phase of platelet function involves platelets binding together through activated GPIIbIIIa receptors by fibrinogen bridges?
Platelet Aggregation
Which drug target inhibits COX1 to prevent platelet activation?
Thromboxane (TXA2) inhibitors
In which phase of platelet function do platelets contract using actin, myosin, and ATP?
Clot Retraction
What is the role of Glycoprotein IIb/IIIa Antagonists in platelet function?
Binding to GP IIb/IIIa receptors
How do activated Factor XIII contribute to platelet plug stabilization?
Cross-link fibrinogen to stabilize the plug
What initiates platelet adhesion by binding to collagen and vWF in the exposed subendothelial surface?
Glycoprotein VI (GP VI)
Which event triggers platelet shape changes, making them send out filopodia for better adherence?
Extracellular Ca influx
What is released by activated platelets, especially from alpha and dense granules, during platelet degranulation?
Serotonin, ADP, and fibrinogen
Which substance acts on platelet surface receptors in an autocrine manner during platelet activation?
Thromboxane A2 (TXA2)
What role does thrombin play in platelet activation?
Act on proteinase receptors on platelet surface
Which receptors' affinity is increased by activators like thrombin and epinephrine during platelet activation?
GPIIbIIIa receptors
Which of the following is NOT a component of the platelet cytosol?
Granular endoplasmic reticulum
What is the primary function of the microtubules in the platelet hyalomere?
To maintain the discoid morphology of the platelet
Which of the following statements about the open canalicular system (OCS) is INCORRECT?
It facilitates the formation of pseudopodia during platelet activation
Which of the following glycoprotein molecules are present in the platelet plasmalemma?
All of the above
What is the function of the actin and myosin filaments in the platelet hyalomere?
To serve in platelet movements and retraction during hemostasis
Which of the following is a component of the platelet cell coat?
Glycosaminoglycans
Test your knowledge on platelet adhesion and shape changes. Learn about the binding of platelet glycoproteins to collagen and vWF, as well as the process of platelets changing shape in response to thrombin.
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