Podcast
Questions and Answers
What is the final step that stabilizes and cements the platelet plug to prevent dislodgment?
What is the final step that stabilizes and cements the platelet plug to prevent dislodgment?
- Cross-linking of fibrinogen by thrombin
- Binding of GPIIbIIIa receptors by fibrinogen
- Contraction of actin and myosin in platelets
- Activation of Factor XIII (correct)
Which phase of platelet function involves platelets binding together through activated GPIIbIIIa receptors by fibrinogen bridges?
Which phase of platelet function involves platelets binding together through activated GPIIbIIIa receptors by fibrinogen bridges?
- Secondary Haemostatic Plug formation
- Primary Haemostatic Plug formation
- Clot Retraction
- Platelet Aggregation (correct)
Which drug target inhibits COX1 to prevent platelet activation?
Which drug target inhibits COX1 to prevent platelet activation?
- Thromboxane (TXA2) inhibitors (correct)
- Purinergic (P2Y12) Inhibitors
- Glycoprotein IIb/IIIa Antagonists
- Protease-activated receptor-1 Antagonists
In which phase of platelet function do platelets contract using actin, myosin, and ATP?
In which phase of platelet function do platelets contract using actin, myosin, and ATP?
What is the role of Glycoprotein IIb/IIIa Antagonists in platelet function?
What is the role of Glycoprotein IIb/IIIa Antagonists in platelet function?
How do activated Factor XIII contribute to platelet plug stabilization?
How do activated Factor XIII contribute to platelet plug stabilization?
What initiates platelet adhesion by binding to collagen and vWF in the exposed subendothelial surface?
What initiates platelet adhesion by binding to collagen and vWF in the exposed subendothelial surface?
Which event triggers platelet shape changes, making them send out filopodia for better adherence?
Which event triggers platelet shape changes, making them send out filopodia for better adherence?
What is released by activated platelets, especially from alpha and dense granules, during platelet degranulation?
What is released by activated platelets, especially from alpha and dense granules, during platelet degranulation?
Which substance acts on platelet surface receptors in an autocrine manner during platelet activation?
Which substance acts on platelet surface receptors in an autocrine manner during platelet activation?
What role does thrombin play in platelet activation?
What role does thrombin play in platelet activation?
Which receptors' affinity is increased by activators like thrombin and epinephrine during platelet activation?
Which receptors' affinity is increased by activators like thrombin and epinephrine during platelet activation?
Which of the following is NOT a component of the platelet cytosol?
Which of the following is NOT a component of the platelet cytosol?
What is the primary function of the microtubules in the platelet hyalomere?
What is the primary function of the microtubules in the platelet hyalomere?
Which of the following statements about the open canalicular system (OCS) is INCORRECT?
Which of the following statements about the open canalicular system (OCS) is INCORRECT?
Which of the following glycoprotein molecules are present in the platelet plasmalemma?
Which of the following glycoprotein molecules are present in the platelet plasmalemma?
What is the function of the actin and myosin filaments in the platelet hyalomere?
What is the function of the actin and myosin filaments in the platelet hyalomere?
Which of the following is a component of the platelet cell coat?
Which of the following is a component of the platelet cell coat?
