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Questions and Answers
What is the main function of the basement membrane or basal lamina?
What is the main function of the basement membrane or basal lamina?
- Generate signals for cellular activities
- Act as a barrier to macromolecules
- Serve as a substratum for cell migration
- Provide mechanical support for attached cells (correct)
What is the primary role of the glycocalyx (cell coat) in the extracellular matrix?
What is the primary role of the glycocalyx (cell coat) in the extracellular matrix?
- Provides mechanical support for cells
- Mediates cell-cell and cell-substratum interactions (correct)
- Helps to bind regulatory factors on the cell surface
- Acts as a barrier to macromolecules
Which protein is the most abundant in the human body?
Which protein is the most abundant in the human body?
- Elastin
- Collagen (correct)
- Laminin
- Fibronectin
What is the thickness range of the basement membrane or basal lamina?
What is the thickness range of the basement membrane or basal lamina?
Which type of tissue does the basement membrane underlie?
Which type of tissue does the basement membrane underlie?
What does collagen primarily consist of?
What does collagen primarily consist of?
What is the role of collagen in the extracellular matrix?
What is the role of collagen in the extracellular matrix?
What is the result of abnormal cell proliferation?
What is the result of abnormal cell proliferation?
What is the term for the spread of a tumor to other parts of the body?
What is the term for the spread of a tumor to other parts of the body?
What leads to promote metastasis according to the text?
What leads to promote metastasis according to the text?
Which type of cells have special properties such as being less adhesive and able to penetrate barriers?
Which type of cells have special properties such as being less adhesive and able to penetrate barriers?
Which junction forms 'belts' near the apical surface called junctional complex?
Which junction forms 'belts' near the apical surface called junctional complex?
'Tight junctions (TJs)' form what specialized contacts between epithelial cells?
'Tight junctions (TJs)' form what specialized contacts between epithelial cells?
Which protein is involved in preventing blood clot formation by acting as a competitive inhibitor to Fibrinogen/Integrin interaction?
Which protein is involved in preventing blood clot formation by acting as a competitive inhibitor to Fibrinogen/Integrin interaction?
What is the primary role of Integrins?
What is the primary role of Integrins?
Which structure is associated with autoimmune and genetic diseases, anchoring epithelial cells to the basement membrane?
Which structure is associated with autoimmune and genetic diseases, anchoring epithelial cells to the basement membrane?
What triggers the activation of cytoplasmic protein kinases, influencing cell behavior and gene expression?
What triggers the activation of cytoplasmic protein kinases, influencing cell behavior and gene expression?
Which glycoproteins are involved in cell migration and found in basement membranes?
Which glycoproteins are involved in cell migration and found in basement membranes?
Which of the following is true about collagen fibers?
Which of the following is true about collagen fibers?
What is the role of Vitamin C in collagen synthesis?
What is the role of Vitamin C in collagen synthesis?
What are the types of collagen mentioned in the text?
What are the types of collagen mentioned in the text?
What is the composition of proteoglycans?
What is the composition of proteoglycans?
What is the function of fibronectin?
What is the function of fibronectin?
What is the role of integrins?
What is the role of integrins?
Study Notes
Extracellular Matrix Components: Collagen, Vitamin C, and Diseases
- Collagen is produced by connective tissues, smooth muscle cells, and epithelial cells.
- There are 28 different types of human collagen, each restricted to specific body locations.
- Collagen's structural features include being a trimer of polypeptide chains and forming a rod-like triple helix.
- Collagen fibers have high tensile strength, capable of supporting 10 kg without breaking.
- Vitamin C is essential for stable collagen synthesis and acts as an antioxidant in the body.
- Types of collagen include fibrillar collagen (Type I and II), non-fibrillar collagen (Type III), and Type IV restricted to the basement membrane.
- Collagen-based diseases result from mutations in collagen genes, leading to various health conditions such as osteogenesis imperfecta and Ehler-Danlos syndromes.
- Proteoglycans consist of a core protein with glycosaminoglycan (GAG) chains attached, forming a highly acidic structure.
- GAGs attract cations and water, creating a hydrated gel that cushions cells and resists crushing forces.
- Fibronectin has a modular structure with binding sites for other extracellular matrix components and guides migrating cells during embryogenesis.
- Integrins mediate adhesion between cells and their environment, with the RGD tripeptide sequence facilitating binding to various extracellular proteins.
- RGD is also required for platelet aggregation during fibrin clotting.
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Description
Test your knowledge on blood clot formation and the role of RGD peptide in inhibiting the interaction between fibrinogen and integrin. This quiz covers the mechanism of platelet adhesion, the function of RGD peptide, and the impact of anti-RGDAb drugs.
