Platelet Adhesion and Shape Changes Quiz
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Questions and Answers

What triggers platelet shape changes during hemostasis?

  • Thrombin acting on proteinase receptors (correct)
  • Extracellular Ca influx triggering intracellular Ca release
  • Platelet glycoprotein binding to collagen and vWF
  • Alpha and dense granules degranulating
  • Which molecule is released by activated platelets in the process of degranulation?

  • Von Willebrand Factor
  • Serotonin (correct)
  • Glycoprotein VI
  • Fibrinogen
  • What is the role of TXA2 in platelet activation?

  • Triggers platelet shape changes
  • Causes platelet aggregation
  • Increases GPIIbIIIa receptors affinity (correct)
  • Acts as a proteinase receptor
  • What is the function of COX1 during platelet activation?

    <p>Converts arachidonic acid to TXA2</p> Signup and view all the answers

    How do platelets begin to adhere better to the underlying sub-endothelium?

    <p>Loss of discoid shape and formation of filopodia</p> Signup and view all the answers

    Which molecule is NOT released by activated platelets during degranulation?

    <p>Thrombin</p> Signup and view all the answers

    What initiates platelet aggregation by increasing the GPIIbIIIa receptors affinity?

    <p>TXA2</p> Signup and view all the answers

    What is the function of the demarcation membranes in platelet structure?

    <p>Outline areas of cytoplasm that will be fragmented to form platelets</p> Signup and view all the answers

    What is the primary role of the Hyalomere in platelets?

    <p>Maintain discoid morphology</p> Signup and view all the answers

    Which component of platelets is responsible for exerting haemostatic functions through movements and retraction?

    <p>Cytosol</p> Signup and view all the answers

    What is the role of the open canalicular system (OCS) in platelets?

    <p>Connect to invaginations of plasmalemma for releasing granule contents</p> Signup and view all the answers

    Which molecule interacts with vessel wall components and plays a role in platelet adhesion?

    <p>Polymorphic glycoprotein molecules</p> Signup and view all the answers

    What is the main function of the tubular system in platelets?

    <p>Assist in shape change and activation</p> Signup and view all the answers

    What is the primary source of platelets in the body?

    <p>Megakaryocytes</p> Signup and view all the answers

    Which of the following is a characteristic of megakaryocytes?

    <p>Extensive Golgi complex</p> Signup and view all the answers

    What happens to the nucleus of a megakaryoblast during platelet formation?

    <p>It becomes polyploid</p> Signup and view all the answers

    Which organelle plays a crucial role in platelet production?

    <p>Mitochondria</p> Signup and view all the answers

    What is the lifespan of a platelet in the blood?

    <p>~10 days</p> Signup and view all the answers

    Which feature distinguishes platelets from other blood cells?

    <p>Non-nucleated nature</p> Signup and view all the answers

    During platelet activation, what is the main function of thrombin?

    <p>Initiating platelet degranulation and release of granule contents</p> Signup and view all the answers

    What process occurs as a result of platelet plug formation?

    <p><em>Thrombosis</em></p> Signup and view all the answers

    Which organelle is primarily involved in Ca sequestration and release during resting states and activation in platelets?

    <p>Dense tubular system</p> Signup and view all the answers

    Which type of granules in platelets contain growth factors, adhesive proteins, and coagulation factors?

    <p>Alpha granules</p> Signup and view all the answers

    What type of molecules are contained in Delta granules in platelets?

    <p>Serotonin and ATP</p> Signup and view all the answers

    Which organelle in platelets contains hydrolytic enzymes that aid in clot resorption?

    <p>Lysosomes (Lambda granules)</p> Signup and view all the answers

    During vasoconstriction, which molecules are secreted from Delta granules of platelets?

    <p>ADP and ATP</p> Signup and view all the answers

    Platelets deaccelerate by tethering within seconds at the site of injury to the vessel wall. Which process do platelets play a role in during the haemostatic process?

    <p>Blood coagulation</p> Signup and view all the answers

    Which part of the platelet contains a system of enzymes that allow for the catabolization of glycogen and generation of ATP?

    <p>Granulomere</p> Signup and view all the answers

    Which type of granules in platelets function as lysosomes containing hydrolytic enzymes for clot resorption?

    <p>Lambda granules</p> Signup and view all the answers

    What is the final step that stabilizes and cement the platelet plug?

    <p>Cross-linking and polymerization of fibrin by activated Factor XIII</p> Signup and view all the answers

    Which drug inhibits COX1 leading to inhibition of Thromboxane (TXA2) involved in platelet activation?

    <p>Thromboxane (TXA2) inhibitors</p> Signup and view all the answers

    In platelet aggregation, which receptors bind together via fibrinogen bridges?

    <p>GPIIbIIIa receptors</p> Signup and view all the answers

    What is the primary haemostatic plug primarily composed of?

    <p>Fibrinogen bridges</p> Signup and view all the answers

    Which enzyme activates fibrinogen to fibrin during clot retraction and stabilization?

    <p>Thrombin</p> Signup and view all the answers

    What role does thrombin play in platelet activation?

    <p>Activating platelets to secrete granules</p> Signup and view all the answers

    Which of the following action is inhibited by Purinergic (P2Y12) Inhibitors used as antiplatelet agents?

    <p>ADP binding to its receptors on platelets</p> Signup and view all the answers

    'Platelet degranulation' refers to the process where platelets release their:

    <p>ADP content</p> Signup and view all the answers

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