Podcast
Questions and Answers
What triggers platelet shape changes during hemostasis?
What triggers platelet shape changes during hemostasis?
- Thrombin acting on proteinase receptors (correct)
- Extracellular Ca influx triggering intracellular Ca release
- Platelet glycoprotein binding to collagen and vWF
- Alpha and dense granules degranulating
Which molecule is released by activated platelets in the process of degranulation?
Which molecule is released by activated platelets in the process of degranulation?
- Von Willebrand Factor
- Serotonin (correct)
- Glycoprotein VI
- Fibrinogen
What is the role of TXA2 in platelet activation?
What is the role of TXA2 in platelet activation?
- Triggers platelet shape changes
- Causes platelet aggregation
- Increases GPIIbIIIa receptors affinity (correct)
- Acts as a proteinase receptor
What is the function of COX1 during platelet activation?
What is the function of COX1 during platelet activation?
How do platelets begin to adhere better to the underlying sub-endothelium?
How do platelets begin to adhere better to the underlying sub-endothelium?
Which molecule is NOT released by activated platelets during degranulation?
Which molecule is NOT released by activated platelets during degranulation?
What initiates platelet aggregation by increasing the GPIIbIIIa receptors affinity?
What initiates platelet aggregation by increasing the GPIIbIIIa receptors affinity?
What is the function of the demarcation membranes in platelet structure?
What is the function of the demarcation membranes in platelet structure?
What is the primary role of the Hyalomere in platelets?
What is the primary role of the Hyalomere in platelets?
Which component of platelets is responsible for exerting haemostatic functions through movements and retraction?
Which component of platelets is responsible for exerting haemostatic functions through movements and retraction?
What is the role of the open canalicular system (OCS) in platelets?
What is the role of the open canalicular system (OCS) in platelets?
Which molecule interacts with vessel wall components and plays a role in platelet adhesion?
Which molecule interacts with vessel wall components and plays a role in platelet adhesion?
What is the main function of the tubular system in platelets?
What is the main function of the tubular system in platelets?
What is the primary source of platelets in the body?
What is the primary source of platelets in the body?
Which of the following is a characteristic of megakaryocytes?
Which of the following is a characteristic of megakaryocytes?
What happens to the nucleus of a megakaryoblast during platelet formation?
What happens to the nucleus of a megakaryoblast during platelet formation?
Which organelle plays a crucial role in platelet production?
Which organelle plays a crucial role in platelet production?
What is the lifespan of a platelet in the blood?
What is the lifespan of a platelet in the blood?
Which feature distinguishes platelets from other blood cells?
Which feature distinguishes platelets from other blood cells?
During platelet activation, what is the main function of thrombin?
During platelet activation, what is the main function of thrombin?
What process occurs as a result of platelet plug formation?
What process occurs as a result of platelet plug formation?
Which organelle is primarily involved in Ca sequestration and release during resting states and activation in platelets?
Which organelle is primarily involved in Ca sequestration and release during resting states and activation in platelets?
Which type of granules in platelets contain growth factors, adhesive proteins, and coagulation factors?
Which type of granules in platelets contain growth factors, adhesive proteins, and coagulation factors?
What type of molecules are contained in Delta granules in platelets?
What type of molecules are contained in Delta granules in platelets?
Which organelle in platelets contains hydrolytic enzymes that aid in clot resorption?
Which organelle in platelets contains hydrolytic enzymes that aid in clot resorption?
During vasoconstriction, which molecules are secreted from Delta granules of platelets?
During vasoconstriction, which molecules are secreted from Delta granules of platelets?
Platelets deaccelerate by tethering within seconds at the site of injury to the vessel wall. Which process do platelets play a role in during the haemostatic process?
Platelets deaccelerate by tethering within seconds at the site of injury to the vessel wall. Which process do platelets play a role in during the haemostatic process?
Which part of the platelet contains a system of enzymes that allow for the catabolization of glycogen and generation of ATP?
Which part of the platelet contains a system of enzymes that allow for the catabolization of glycogen and generation of ATP?
Which type of granules in platelets function as lysosomes containing hydrolytic enzymes for clot resorption?
Which type of granules in platelets function as lysosomes containing hydrolytic enzymes for clot resorption?
What is the final step that stabilizes and cement the platelet plug?
What is the final step that stabilizes and cement the platelet plug?
Which drug inhibits COX1 leading to inhibition of Thromboxane (TXA2) involved in platelet activation?
Which drug inhibits COX1 leading to inhibition of Thromboxane (TXA2) involved in platelet activation?
In platelet aggregation, which receptors bind together via fibrinogen bridges?
In platelet aggregation, which receptors bind together via fibrinogen bridges?
What is the primary haemostatic plug primarily composed of?
What is the primary haemostatic plug primarily composed of?
Which enzyme activates fibrinogen to fibrin during clot retraction and stabilization?
Which enzyme activates fibrinogen to fibrin during clot retraction and stabilization?
What role does thrombin play in platelet activation?
What role does thrombin play in platelet activation?
Which of the following action is inhibited by Purinergic (P2Y12) Inhibitors used as antiplatelet agents?
Which of the following action is inhibited by Purinergic (P2Y12) Inhibitors used as antiplatelet agents?
'Platelet degranulation' refers to the process where platelets release their:
'Platelet degranulation' refers to the process where platelets release their:
