6 Questions
What is the relationship between the rate of drug absorption and elimination?
Drug absorption is more rapid than elimination
What is the purpose of the plasma drug concentration (level)–time curve?
To measure the rate of drug absorption and elimination
What are the main mechanisms of drug elimination?
Excretion and biotransformation
What is the significance of the minimum effective concentration (MEC) of a drug?
It is the concentration needed to produce a pharmacologic effect
How is the MEC related to the drug concentration in the tissues?
Assuming the drug concentration in the plasma is in equilibrium with the tissues, the MEC reflects the minimum concentration of drug needed
What is the purpose of the minimum toxic concentration (MTC) in the plasma drug concentration-time curve?
The MTC represents the concentration at which the drug becomes toxic
Learn about how the plasma drug concentration-time curve is generated by plotting the drug concentration in plasma samples against time intervals after drug administration. Understand how drug concentrations rise in the bloodstream up to a maximum level as the drug reaches the systemic circulation.
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