Podcast
Questions and Answers
What factor is considered the most important in the absorption of a drug?
What factor is considered the most important in the absorption of a drug?
What does Cmax represent in pharmacokinetics?
What does Cmax represent in pharmacokinetics?
Which of the following statements about drug absorption is correct?
Which of the following statements about drug absorption is correct?
What is the significance of Tmax in pharmacokinetics?
What is the significance of Tmax in pharmacokinetics?
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Which of the following is true regarding intravenous drug administration?
Which of the following is true regarding intravenous drug administration?
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How does the area under the curve (AUC) relate to drug absorption?
How does the area under the curve (AUC) relate to drug absorption?
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In a plasma concentration vs. time graph, what does MTC stand for?
In a plasma concentration vs. time graph, what does MTC stand for?
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What is the relationship between drug solubility and its ability to cross biological membranes?
What is the relationship between drug solubility and its ability to cross biological membranes?
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Study Notes
Pharmacology
- The study of drugs.
Pharmacokinetics
- ADME study: Absorption, Distribution, Metabolism, Excretion.
Absorption
- Movement of a drug from the site of administration to the blood.
- Lipid solubility is the most important factor in absorption.
- The drug will cross the medium if the medium is the same.
- Acidic drugs are lipid-soluble and will cross the membrane when in an acidic medium.
- Basic drugs are lipid-soluble and will cross the membrane when in a basic medium.
- Acidic drugs become ionized and water-soluble in a basic medium, and will not cross the membrane.
Plasma Concentration vs Time Graph
- A graph showing the relationship between plasma concentration and time after drug administration.
- Cmax: Maximum concentration obtained by a particular dose. It should be between the minimum toxic concentration (MTC) and minimum effective concentration (MEC).
- Tmax: Time in which plasma concentration becomes maximum. This indicates the rate of absorption.
- AUC: Total area covered by the graph. This indicates the extent of absorption.
- Rate of absorption: The rate at which a drug is absorbed into the blood.
- Amount: The amount of drug absorbed over time.
- If a drug is administered intravenously (IV), bioavailability is 100%.
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Description
This quiz covers the fundamentals of pharmacokinetics, focusing on drug absorption, distribution, metabolism, and excretion (ADME). It explores the factors influencing absorption and the significance of plasma concentration over time. Test your understanding of key concepts and graphical representations related to drug pharmacology.
