14 Questions
What does the term 'efficacy' refer to in pharmacology?
The greatest maximal response that can be produced from a particular drug
Which of the following statements falls under the category of pharmacokinetics?
The half-life of a drug
What does a high therapeutic index (TI) indicate about a drug?
The drug is safe
If a drug is known to be selective to receptor (A), what does this imply?
Drug (a) cannot bind to receptor (B)
What is the main purpose of therapeutic drug monitoring?
To confirm the therapeutic dose of a drug
How is half-life defined in pharmacokinetics?
The time required for a drug's plasma concentration to decrease by half after administration
How does drug-protein binding affect pharmacological activity?
Drugs bound to plasma proteins are inactive and do not produce any effect
What does a higher volume of distribution (Vd) indicate about a drug?
The drug is distributed throughout the body in higher amounts
What does drug elimination primarily refer to?
1 and 2
What is the main goal when administering a drug on multiple doses over an extended period?
To ensure drug plasma level remains within the therapeutic range
Which term is used to describe the dose required to produce a specific therapeutic response in 50% of a group of patients?
Median effective dose (ED50)
What does the Therapeutic Index (TI) describe?
The ratio of LD50 to ED50
What is the significance of a large Therapeutic Index (TI) value for a drug?
It signifies that the drug is relatively safe
Which aspect of pharmacokinetics does not involve drug-receptor binding?
Elimination
Test your knowledge on the bioavailability of amoxicillin based on drug plasma concentration. Determine the percentage of amoxicillin that reached the circulation after a specific dose was administered.
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