Human Physiology Week 9 - Respiratory (Transcripts)

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Questions and Answers

What physiological event occurs during hypopnea?

Shallow breathing during deep sleep (correct)

Difficulty in moving air in and out

Complete cessation of breathing

Inflation of the thoracic cavity

Which of the following best describes dyspnea?

An increase in thoracic cavity volume

An absence of breathing

A condition requiring active muscle contraction

A sensation of difficulty in breathing (correct)

What is a key difference between inspiration and expiration during normal breathing at rest?

Expiration leads to an increase in thoracic cavity pressure

Inspiration is a passive process

Expiration requires energy from ATP

Inspiration involves muscular contraction (correct)

In which condition might dyspnea occur without observable signs?

Exercise-induced shortness of breath Signup and view all the answers

How does the diaphragm contribute to ventilation during inspiration?

By contracting and moving downward Signup and view all the answers

Which component of breathing involves the movement of air in and out of the lungs?

Ventilation Signup and view all the answers

What is the primary purpose of gas exchange during breathing?

To transfer oxygen to the bloodstream and remove carbon dioxide Signup and view all the answers

How does perfusion relate to the process of breathing?

It is the blood flow necessary for gas exchange in the lungs. Signup and view all the answers

What function does the brain serve in the control of breathing?

It regulates ventilation depth and breathing rate unconsciously. Signup and view all the answers

Which statement best summarizes the four components of breathing?

All components are interdependent, affecting overall respiratory function. Signup and view all the answers

Which term best describes normal, healthy breathing?

Eupnea Signup and view all the answers

What is the relationship between tidal volume and respiratory rate in determining minute ventilation?

Minute ventilation equals tidal volume times respiratory rate. Signup and view all the answers

How is hyperpnea characterized compared to eupnea?

Increased tidal volume and respiratory rate to meet metabolic demands. Signup and view all the answers

What distinguishes hyperventilation from hyperpnea?

Hyperventilation leads to lower carbon dioxide levels despite normal metabolic demands. Signup and view all the answers

Which condition is described by an increased breathing rate without an increase in tidal volume?

Tachypnea Signup and view all the answers

What happens to the intrapleural pressure during inspiration?

It becomes more negative than atmospheric pressure. Signup and view all the answers

Which statement accurately describes the process of expiration at rest?

It is a passive process that does not require ATP. Signup and view all the answers

Why is there an increase in ventilation during exercise?

To eliminate excess carbon dioxide from the body. Signup and view all the answers

What role do additional muscles play during inspiration when exercising?

They expand the rib cage further and lower intrapleural pressure. Signup and view all the answers

What occurs to the alveolar pressure during expiration?

It increases above atmospheric pressure. Signup and view all the answers

What happens to abdominal and thoracic pressures during active expiration?

They increase to help expel air. Signup and view all the answers

Which muscle is NOT typically recruited during active inspiration?

Rectus abdominis Signup and view all the answers

What characterizes phonation in relation to respiration?

It involves voluntary control of skeletal muscles. Signup and view all the answers

Which of the following muscles primarily aids in active expiration?

Internal intercostals Signup and view all the answers

During exercise, which statement about expiration is accurate?

Both inspiration and expiration become active processes. Signup and view all the answers

Study Notes

Breathing Basics

Breathing involves ventilation, gas exchange, perfusion, and control.
Ventilation is the movement of air in and out of the lungs.
Gas exchange is the movement of oxygen and carbon dioxide across the alveolar capillary membrane.
Perfusion is blood flow through the lungs.
Control of breathing is automatic and regulated by the brain.

Quantification of Breathing

Tidal volume is the amount of air moved during each breath.
Respiratory rate (respiratory frequency) is the number of breaths per minute.
Minute ventilation (ventilatory equivalent) is the amount of air moved through the lungs per minute, calculated by multiplying tidal volume and respiratory rate.
Eupnea is normal, healthy breathing.
Hyperpnea is increased breathing rate and tidal volume to meet metabolic demands during exercise.
Hyperventilation is rapid breathing exceeding metabolic demands, often experienced during panic attacks.
Tachypnea is an increased breathing rate with minimal change in tidal volume.
Bradypnea is a decreased breathing rate.
Hypopnea is slow, shallow breathing during deep sleep.
Apnea is the absence of breathing, like during sleep apnea.
Dyspnea is difficulty breathing, which can be a symptom or a sign, and may have physiological or psychological causes.

Mechanics of Inspiration and Expiration

Inspiration is an active process involving muscular contraction, primarily the diaphragm.
Expiration is a passive process where the diaphragm relaxes.
Inspiration involves the diaphragm moving downward, expanding the thoracic cavity, creating a more negative intrapleural pressure, pulling open the alveoli, and lowering alveolar pressure.
Expiration occurs when the diaphragm moves upward, increasing intrapleural pressure, compressing the alveoli, and raising alveolar pressure, forcing air out.

Inspiration and Expiration at Rest

At rest, inspiration is an active process while expiration is passive.
Inspiration involves actively contracting the diaphragm muscle, requiring ATP.
Expiration involves passively relaxing the diaphragm, not requiring ATP.

Inspiration and Expiration During Exercise

During exercise, there is increased ventilation as more oxygen is needed and carbon dioxide needs to be removed from the bloodstream.
During exercise, inspiration becomes even more active, involving more muscles to expand the thoracic cavity further, decreasing intrapleural pressure, pulling open the alveoli even more, and lowering alveolar pressure for faster air intake.
During exercise, expiration also utilizes more muscles to actively force air out.

Breathing Mechanics During Exercise

During exercise, expiration becomes active to expel carbon dioxide from the alveoli.
To achieve active expiration, abdominal muscles (rectus abdominis and internal obliques) contract to increase abdominal and thoracic pressure.
Internal intercostal muscles also help to forcefully expire.
During active inspiration, accessory inspiratory muscles are recruited:
- Scalenes, sternocleidomastoid, latissimus dorsi, pectoralis major, pectoralis minor, external obliques, and external intercostal muscles all contribute to expanding the thoracic cavity.

Energy Demands Of Breathing

At rest, breathing accounts for about 3-5% of our energy expenditure.
During exercise, inspiratory and expiratory muscles demand more energy.
Well-trained athletes can dedicate up to 15% of their exercise energy to breathing.
Respiratory pathologies can lead to increased energy requirements for breathing, even at rest:
- Restrictive lung diseases (e.g., pulmonary fibrosis, obesity) impede lung expansion, requiring more effort.
- Obstructive lung diseases (e.g., COPD) constrict airways, making exhaling more difficult.
Individuals with cystic fibrosis, COPD, or obesity have significantly higher energy demands for breathing.
Over-activation of accessory respiratory muscles over time can lead to:
- Inflammatory changes
- Degenerative changes
- Respiratory failure

Neurological Control Of Breathing

Breathing is voluntary but automatically controlled by the somatic nervous system.
Brain centers in the medulla and pons regulate breathing through the respiratory center.
Dorsal respiratory group (DRG) in the medulla controls inspiration:
- Activates the diaphragm and external intercostals
- Stimulated by the phrenic nerve
Ventral respiratory group (VRG) in the medulla controls expiration:
- Becomes active during active expiration
- Activates internal intercostal muscles.
Pontine respiratory group (PRG) in the pons influences breath timing and depth:
- Apneustic center ramps up inspiration
- Pneumotaxic center inhibits inspiration, controlled by mechanoreceptors in the lungs.
The pneumotaxic center plays a key role in regulating breathing rate and depth.

Key Terms To Remember

Inspiration: Inhaling
Expiration: Exhaling
Alveoli: Tiny air sacs in the lungs
Intrapleural pressure: Pressure within the space between the lungs and chest wall
Somatic nervous system: Controls voluntary movements
Autonomic nervous system: Controls involuntary functions
Mechanoreceptor: Sensory receptor that responds to mechanical pressure.

The Valsalva Maneuver

The Valsalva maneuver is a physiologic process that involves forcefully expiring against a closed glottis.
It is a common occurrence during activities like lifting heavy weights or straining.
It causes physiological changes that involve four distinct phases.

Phase 1 - Increased Thoracic Cavity Pressure

Increased pressure in the thoracic cavity squeezes the vena cava.
Blood from the vena cava is diverted to the right atrium due to lower pressure in the atrium.
Increased blood flow to the right atrium triggers the Frank Starling mechanism, leading to increased end-diastolic volume in the right ventricle.
This stretching of the right ventricle causes increased contractility.
The Bainbridge Reflex is also triggered due to increased right atrial pressure.
The Bainbridge Reflex activates the sympathetic nervous system, leading to further increased contractility of the right atrium and ventricle.
Increased cardiac contractility requires more ATP and subsequently greater oxygen delivery to the myocardium.

Phase 2 - Reduced Venous Return

Sustained pressure on the vena cava impedes venous return.
Reduced venous return leads to a decrease in blood flow to the right atrium and ventricle.
Decreased end-diastolic volume and stroke volume occur.
Lower stroke volume reduces blood flow and lowers arterial blood pressure, detected by aortic baroreceptors.
Baroreceptors activate the sympathetic nervous system to increase contractility to compensate for low blood pressure.
Increased contractility during this phase is driven by the need to compensate for reduced blood flow and pressure, unlike phase one.
Increased contractility increases myocardial demand for oxygen.

Phase 3 - Glottis Release

The glottis is opened, releasing the held breath.
Vena cava starts to refill with blood.
There is a time delay before the increased blood volume in the vena cava reaches the heart.
Cardiac output remains lower than normal as the heart hasn't fully refilled yet.
Sympathetic nervous system stimulation continues to maintain blood pressure.
The compression of coronary arteries from the previous phases is relieved, increasing blood flow to the myocardium.
Myocardial oxygen demand remains high.

Phase 4 - Blood Surge to the Heart

Excess blood from the vena cava enters the right atrium, increasing right atrial pressure.
The Bainbridge Reflex is activated again, increasing contractility of the right atrium and ventricle to expel excess blood.
Increased contractility in this phase is due to the Bainbridge Reflex, unlike phase one, where it was due to the Frank Starling mechanism and the Bainbridge Reflex.
Coronary arteries are not compressed, allowing better blood flow to meet the increased myocardial demand.

Valsalva Maneuver and Cardiovascular Disease

The Valsalva maneuver requires increased oxygen delivery to the myocardium in healthy individuals with normal vascular function.
Healthy individuals can compensate for increased oxygen demand through vasodilation of coronary arteries.
Individuals with atherosclerosis have smaller-diameter coronary arteries with reduced vasodilatory capacity.
The compressed thoracic cavity during the Valsalva maneuver, along with reduced venous return, further restricts blood flow to the myocardium in individuals with atherosclerosis.
Restricted blood flow in individuals with atherosclerosis may result in an inability to meet myocardial oxygen demand.
Insufficient oxygen supply leads to decreased contractility, further lowering stroke volume and cardiac output.
Reduced blood flow to the myocardium can cause angina, a pain sensation in the chest due to inadequate oxygen delivery.
Sympathetic nervous system activation cannot effectively compensate due to restricted blood flow, leading to further impairment of cardiac function.

Valsalva Maneuver

The Valsalva maneuver is dangerous for individuals with atherosclerosis because it can lead to heart attacks.
During a Valsalva maneuver, increased pressure is exerted due to the forced expiration against a closed glottis, leading to a reduction of blood flow to the heart.
This decrease in blood flow, coupled with increased demand for oxygen in the contracting muscles, creates a mismatch, putting additional strain on the already weakened heart.
Additionally, the pressure fluctuations caused by the Valsalva maneuver can destabilize plaque in coronary arteries, potentially leading to its detachment and blockage of blood vessels.

Valsalva Maneuver and Exercise

It is crucial to avoid Valsalva maneuvers during exercise, especially for individuals with cardiovascular risk factors like atherosclerosis and hypertension.
Encouraging proper breathing techniques during exercise, such as exhaling during the active phase of a lift, helps prevent Valsalva maneuvers.

Cough Reflex

The cough reflex is a physiological process that involves a series of steps: deep inspiration, closure of the glottis, forceful expiration against a closed glottis, and finally, the release of the glottis, causing an explosive outward airflow.
The cough reflex is triggered by either mechanical or chemical irritations to the respiratory tract, such as a crumb in the pharynx or exposure to chlorine.

Cough Reflex and Physical Implications

The forceful muscle contractions involved in coughing can potentially lead to further complications in patients with abdominal or thoracic injuries.
In cases of abdominal surgery or rib fracture, coughing is generally contraindicated due to the increased pressure it can exert on healing tissues.
Cough suppressants may be beneficial in situations where coughing is contraindicated.

Sneeze Reflex

The sneeze reflex is similar to the cough reflex, but it is triggered by irritations to the nasal mucosa, either physical or chemical.
The process of sneezing follows the same pattern as coughing: deep inspiration, closure of epiglottis, forceful expiration against a closed epiglottis, followed by the release of the epiglottis, leading to a forceful expulsion of air.
Sneezing doesn't always involve only the nose, and it can also occur through the mouth.

Autosomal Compelling Helio Ophthalmic Output Syndrome (ACHOO)

A genetic condition known as ACHOO (autosomal compelling helio ophthalmic output syndrome) is a rare, but interesting, example of a sneeze trigger not related to nasal mucosa.
Individuals with ACHOO experience sneezing in response to exposure to bright sunlight.
This condition is caused by a genetic mutation affecting the ophthalmic nerve, which connects the eyes to the brain.

Cough Reflex and Sneeze Reflex Control

Both coughing and sneezing involve voluntary muscle contractions controlled by the somatic nervous system.
While the default response is automatic, individuals can sometimes exert conscious control to suppress or modify these reflexes.

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Description

This quiz explores key concepts around the physiology of breathing, including normal and abnormal respiratory patterns, gas exchange, and the role of the diaphragm. It covers distinctions between various breathing conditions such as hypopnea, dyspnea, hyperpnea, and hyperventilation. Test your knowledge on how breathing is regulated and its physiological implications.