Lipids 1

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Questions and Answers

What is the main role of glycolipids in the cell membrane?

  • Contain phosphate groups for stability
  • Maintain stability and facilitate cellular recognition (correct)
  • Facilitate the spread of infection
  • Dissolve cell membranes

Which enzymes are produced by pathogenic bacteria to dissolve cell membranes?

  • Sphingomyelinases
  • Carbonyl reductases
  • Cholesterol esterases
  • Phospholipases (correct)

Which molecule is a component of glycosphingolipids but not phospholipids?

  • Phosphate
  • Fatty acid
  • Sphingosine
  • Ceramide (correct)

What is attached to the amino alcohol sphingosine in glycosphingolipids?

<p>Fatty acid unit (A)</p> Signup and view all the answers

Which of the following is NOT a subclass of glycolipids?

<p>Phosphatidylcholine (B)</p> Signup and view all the answers

What is the main outcome of attaching different polar head groups to diacylglycerol?

<p>Degradation by phospholipases (C)</p> Signup and view all the answers

What type of molecule is a phospholipid?

<p>Amphipathic (D)</p> Signup and view all the answers

Which of the following is a molecule with high physiological and metabolic relevance?

<p>Diacylglycerol (D)</p> Signup and view all the answers

Which lipid serves as the building blocks of other lipids?

<p>Glycerophospholipids (C)</p> Signup and view all the answers

What type of fatty acids are SFA and UFA?

<p>Saturated and unsaturated (B)</p> Signup and view all the answers

Which category includes prostaglandins, thromboxanes, and leukotrienes?

<p>Eicosanoids (C)</p> Signup and view all the answers

What is the precursor for all classes of steroid hormones?

<p>Cholesterol (B)</p> Signup and view all the answers

Why do steroid hormones need to be attached to plasma proteins for transportation in the blood?

<p>Due to hydrophobicity (A)</p> Signup and view all the answers

Which lipoprotein functions to keep its component lipids soluble for transport in plasma?

<p>High-density lipoproteins (HDL) (B)</p> Signup and view all the answers

Where do abnormalities in lipoprotein metabolism generally occur?

<p>At the site of lipid utilization (B)</p> Signup and view all the answers

Which type of lipoprotein has the highest density?

<p>High-density lipoproteins (HDL) (D)</p> Signup and view all the answers

What is the function of plasma lipoproteins?

<p>To provide a mechanism for lipid transport in plasma (C)</p> Signup and view all the answers

What is the main source of essential fatty acids that must be obtained from the diet?

<p>Fish oils (C)</p> Signup and view all the answers

Which fatty acid is the precursor of arachidonic acid, which is important for eicosanoid synthesis?

<p>Linoleic acid (B)</p> Signup and view all the answers

In phospholipids, what type of group links the polar head and nonpolar fatty acid tails?

<p>Phosphate group (C)</p> Signup and view all the answers

Why are phospholipids considered amphipathic in nature?

<p>They have both hydrophilic and hydrophobic components (C)</p> Signup and view all the answers

Which part of a phospholipid molecule points outward to the aqueous environment in cell membranes?

<p>Hydrophilic head (A)</p> Signup and view all the answers

Apart from being main components of cell membranes, where else can nonmembrane phospholipids be found?

<p>In lung surfactants (A)</p> Signup and view all the answers

What is the physiological relevance of cardiolipin?

<p>Maintenance of electron transport chain complexes (D)</p> Signup and view all the answers

Which function is NOT associated with platelet-activating factor (PAF)?

<p>Enhances erythrocyte production (D)</p> Signup and view all the answers

Where does the synthesis of glycerophospholipids primarily occur?

<p>Smooth Endoplasmic Reticulum (sER) (B)</p> Signup and view all the answers

Which process results in the conversion of phosphatidic acid to diacylglycerol?

<p>Phosphatase action (C)</p> Signup and view all the answers

In phospholipid biosynthesis, what is the precursor molecule for glycerophospholipids?

<p>Fatty acyl CoA (B)</p> Signup and view all the answers

Which organelle is responsible for modifying newly synthesized phospholipids before they compose cell membranes?

<p>Golgi Apparatus (B)</p> Signup and view all the answers

What type of fatty acids are the building blocks of lipids?

<p>Saturated and unsaturated fatty acids (D)</p> Signup and view all the answers

Which lipid molecule is a combination of a fatty acid with an alcohol such as glycerol?

<p>Neutral fats (D)</p> Signup and view all the answers

In glycerophospholipids, what is the primary role of the glycerol backbone?

<p>Linking the polar head to the nonpolar fatty acid tails (B)</p> Signup and view all the answers

What is the main function of triacylglycerols (TAG) in cells?

<p>Provide energy during fasting periods (A)</p> Signup and view all the answers

In what form are fatty acids mainly circulating in the blood plasma?

<p>Esterified forms within lipoprotein particles (B)</p> Signup and view all the answers

Why do long-chain-length fatty acids (LCFA) require association with proteins for blood plasma circulation?

<p>To increase their solubility in water (A)</p> Signup and view all the answers

What effect does the presence of double bonds have on the melting temperature (Tm) of fatty acids?

<p>Decreases the Tm (C)</p> Signup and view all the answers

Which aspect of fatty acid structure gives them an amphipathic nature?

<p>Anionic group (D)</p> Signup and view all the answers

What structural characteristic defines saturated fatty acids?

<p>Absence of double bonds (A)</p> Signup and view all the answers

What is the main function of cholesteryl esters (CE) in the body?

<p>Modulate the fluidity of lipoproteins (D)</p> Signup and view all the answers

Why are cholesteryl esters (CE) not found in cell membranes?

<p>They are only present in low levels associated with lipoproteins (B)</p> Signup and view all the answers

What role does the liver play in cholesterol homeostasis in the body?

<p>It controls the delicate balance of cholesterol levels in the body (B)</p> Signup and view all the answers

How does cholesterol contribute to the formation of dangerous plaque formations?

<p>Due to disturbances in the balance controlled by the liver (D)</p> Signup and view all the answers

Which statement accurately describes cholesterol's role as a sterol?

<p>Cholesterol acts as a precursor for eicosanoid synthesis (A)</p> Signup and view all the answers

In what form do most plasma cholesterol exist for transport?

<p>Cholesteryl esters with fatty acids attached (B)</p> Signup and view all the answers

What is the role of cardiolipin in the cell?

<p>Maintains electron transport chain complexes (D)</p> Signup and view all the answers

Where does the synthesis of glycerophospholipids primarily occur?

<p>Endoplasmic reticulum (D)</p> Signup and view all the answers

What is the function of platelet-activating factor (PAF) in the body?

<p>Activates inflammatory cells (C)</p> Signup and view all the answers

What role does the smooth endoplasmic reticulum (sER) play in phospholipid synthesis?

<p>Produces phospholipids from precursors (C)</p> Signup and view all the answers

What is the precursor molecule for glycerophospholipids in phospholipid biosynthesis?

<p>Fatty acyl CoA (D)</p> Signup and view all the answers

Which organelle is responsible for modifying newly synthesized phospholipids before they become part of cell membranes?

<p>Golgi apparatus (A)</p> Signup and view all the answers

Why must steroid hormones be attached to plasma proteins for transportation in the blood?

<p>To enhance their solubility due to their hydrophobic nature (C)</p> Signup and view all the answers

Which lipoprotein has the highest density among the listed types?

<p>High-density lipoproteins (HDL) (D)</p> Signup and view all the answers

Where do abnormalities in lipoprotein metabolism generally occur?

<p>At the site of lipoprotein production (A)</p> Signup and view all the answers

What is the main function of plasma lipoproteins?

<p>To keep their component lipids soluble for transport in plasma (C)</p> Signup and view all the answers

In what way do chylomicrons, VLDL, LDL, and HDL differ from each other?

<p>Lipid and protein composition, size, density, and site of origin (C)</p> Signup and view all the answers

What is the precursor for all classes of steroid hormones?

<p>Cholesterol (B)</p> Signup and view all the answers

What is the main component of lecithin?

<p>Phosphatidylcholine (A)</p> Signup and view all the answers

Which type of phospholipid is an important component of the myelin sheath of nerve fibers?

<p>Sphingomyelin (A)</p> Signup and view all the answers

What is the precursor molecule of phosphatidylinositol?

<p>Inositol (D)</p> Signup and view all the answers

Which alcohol group is involved in the synthesis of Phosphatidylethanolamine?

<p>Ethanolamine (A)</p> Signup and view all the answers

What is the main outcome of attaching serine to phosphatidic acid?

<p>Formation of Phosphatidylserine (D)</p> Signup and view all the answers

Which phospholipid is essential for regulating intracellular signaling, lipid transportation, and vesicular trafficking?

<p>Phosphatidylinositol (D)</p> Signup and view all the answers

What is the physiological relevance of cardiolipin in the cell?

<p>Maintains electron transport chain complexes (B)</p> Signup and view all the answers

Where does the synthesis of phospholipids primarily occur?

<p>Smooth endoplasmic reticulum (sER) (B)</p> Signup and view all the answers

Which organelle is responsible for modifying newly synthesized phospholipids before they become part of cell membranes?

<p>Golgi apparatus (C)</p> Signup and view all the answers

What is the precursor molecule for glycerophospholipids in phospholipid biosynthesis?

<p>Glycerol-3-phosphate (D)</p> Signup and view all the answers

What is the primary role of platelet-activating factor (PAF) in the body?

<p>Induces hypersensitivity reactions (C)</p> Signup and view all the answers

How are glycerophospholipids synthesized?

<p>$2$ fatty acids linked to coenzyme A are joined to glycerol-3-phosphate. (A)</p> Signup and view all the answers

What is the term used to describe fatty acids with 13-21 carbons?

<p>Long-chain fatty acids (LCFA) (D)</p> Signup and view all the answers

Which carbon atom in a fatty acid is referred to as the α-carbon?

<p>Carbon 2 (A)</p> Signup and view all the answers

What is the reference point used to name double bonds in a fatty acid?

<p>ω-carbon (C)</p> Signup and view all the answers

Arachidonic acid is categorized as an ω-6 fatty acid because:

<p>The first double bond is six carbons from the ω end (B)</p> Signup and view all the answers

What is the term used to describe fatty acids with fewer than 5 carbons?

<p>Short-chain fatty acids (SCFA) (A)</p> Signup and view all the answers

What is the function of glycosphingolipids located in the outer parts of the plasma membrane?

<p>Antigenic/recognition function (B)</p> Signup and view all the answers

Which blood group antigen is associated with the presence of GalNAc as the terminal sugar on the glycan?

<p>A (B)</p> Signup and view all the answers

What is the main source of arachidonic acid, the immediate precursor of eicosanoids?

<p>Membrane phospholipids (B)</p> Signup and view all the answers

Which lipid derivatives are classified as local hormones due to their acting locally and not being stored?

<p>Prostaglandins, thromboxanes, and leukotrienes (D)</p> Signup and view all the answers

Which lipid molecule serves as a mediator of allergic response and inflammation?

<p>Leukotrienes (C)</p> Signup and view all the answers

What is the essential characteristic that distinguishes arachidonic acid from essential fatty acids?

<p>Not stored in tissues (B)</p> Signup and view all the answers

What is the structure of cholesterol consisting of?

<p>Four fused hydrocarbon rings (C)</p> Signup and view all the answers

Where are cholesteryl esters (CE) primarily found in the body?

<p>Associated with lipoproteins (B)</p> Signup and view all the answers

Which molecule is an essential precursor for the synthesis of steroid hormones?

<p>Cholesterol (A)</p> Signup and view all the answers

What is the primary source of cholesterol entry into the liver for maintaining homeostasis?

<p>Dietary intake and de novo synthesis (D)</p> Signup and view all the answers

What crucial function does cholesterol perform in cell membranes?

<p>Enhancing membrane fluidity (A)</p> Signup and view all the answers

In what form is most plasma cholesterol found for transport?

<p>Cholesterol esterified with fatty acids (D)</p> Signup and view all the answers

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