Local Hormones: Histamine and Biologically Active Lipids Quiz

Applying the substance should produce the effect in question, and receptors should be present locally. The synthetic pathway should be present, and the substance generated locally. There should be a mechanism for termination of its effects.

The principal eicosanoids are the prostaglandins, the thromboxanes, and the leukotrienes, although other derivatives of arachidonate, for example the lipoxins, are also produced.

Arachidonate is liberated, usually in a one-step process catalyzed by the enzyme phospholipase A2 (PLA2), although a multi-step process involving phospholipases C or D in conjunction with diacylglycerol lipase is sometimes utilized.

<p>Cytosolic PLA2 is activated (and hence arachidonic acid liberated) by phosphorylation.</p> Signup and view all the answers

<p>The term 'prostanoid' is used to encompass both prostaglandins and thromboxanes.</p> Signup and view all the answers

<p>Interference with synthesis, release, or termination</p> Signup and view all the answers

<p>Phospholipase A2</p> Signup and view all the answers

<p>Prostaglandins, thromboxanes, and lipoxins</p> Signup and view all the answers

<p>Prostanoid</p> Signup and view all the answers

<p>Cytosolic PLA2</p> Signup and view all the answers

<p>Substance that has a synthetic pathway present and is generated locally</p> Signup and view all the answers

<p>Prostanoid</p> Signup and view all the answers

<p>Phospholipase A2 (PLA2)</p> Signup and view all the answers

<p>One-step process involving phospholipase A2 (PLA2)</p> Signup and view all the answers

<p>By phosphorylation</p> Signup and view all the answers