Pharmacy: Types of Tablets

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Questions and Answers

What is added to the dry mixture during wet granulation?

Additive

Solvent

Binder solution (correct)

Active ingredient

What is the purpose of the dryer machine in wet granulation?

To add the binder solution

To mix the raw materials

To dry the wet granules (correct)

To control the moisture content

What is the final product of wet granulation?

Dried granules (correct)

Wet granules

Raw material powder

Binder solution

What is the purpose of Q.C. in wet granulation?

To control the moisture content Signup and view all the answers

What is used as a solvent in wet granulation?

Organic solvent or water Signup and view all the answers

What is the first step in wet granulation?

Dry mixing Signup and view all the answers

What is another name for a single punch tablet press?

Eccentric press Signup and view all the answers

What type of motion does the upper punch exert on the fill material in a single station tablet press?

Hammering motion Signup and view all the answers

Why is a mechanized feeder employed in tablet manufacturing?

To force granules into the die cavity Signup and view all the answers

What is the purpose of a tablet deduster in tablet manufacturing?

To remove excess powder from tablets Signup and view all the answers

What type of tablet press employs a single tooling station?

Single punch tablet press Signup and view all the answers

What is a characteristic of a rotary tablet press?

It has multiple tooling stations Signup and view all the answers

What is the purpose of tablet weight monitoring devices in tablet manufacturing?

To monitor tablet weight Signup and view all the answers

What is a limitation of gravity filling of dies with granules?

Weight variation and content uniformity Signup and view all the answers

What is the core component of a sugar-coated tablet?

Core Tablet Signup and view all the answers

What is the primary function of coating materials in tablets?

To protect tablet ingredients from deterioration by moisture Signup and view all the answers

Which type of tablet is designed to release the drug at a specific site in the gastrointestinal tract?

Enteric coated tablets Signup and view all the answers

What is the primary purpose of plasticizers in soft gelatin capsule preparation?

To produce elasticity and flexibility Signup and view all the answers

What is an important consideration in designing a dosage form?

Physicochemical properties of the drug Signup and view all the answers

Why are excipients present in greater proportion in medicinal products?

They form the bulk of the formulation Signup and view all the answers

What is the purpose of a sustained release tablet?

To release the drug over a prolonged period of time Signup and view all the answers

What is a consideration when designing a dosage form for topical use?

Intended site of action Signup and view all the answers

What is the primary characteristic to consider when selecting an excipient?

Functionality Signup and view all the answers

What is a factor that affects the biopharmaceutical considerations of a dosage form?

Aqueous solubility of the drug Signup and view all the answers

What is the primary purpose of flavors in medicinal products?

To mask unpleasant taste Signup and view all the answers

What is an important characteristic to consider when designing a dosage form for oral administration?

Dissolution characteristics Signup and view all the answers

What is the primary reason for considering regulatory acceptance when selecting an excipient?

To ensure the excipient is compliant with regulations Signup and view all the answers

What is the primary interaction to consider when selecting an excipient?

All of the above Signup and view all the answers

What is a consideration when designing a dosage form for systemic use?

Extent of absorption Signup and view all the answers

What is the primary benefit of using Hydroxypropylmethyl cellulose (HPMC) in coating materials?

It protects tablet ingredients from deterioration by moisture Signup and view all the answers

What is the primary function of a Fette machine?

To chill compression components for low melting point substances Signup and view all the answers

Which of the following is NOT a quality control test for tablets?

Moisture Content Test Signup and view all the answers

What is the purpose of the hardness test in quality control of tablets?

To evaluate the strength and ability of tablets to withstand shocks and frictions Signup and view all the answers

What is the primary purpose of the friability test?

To induce self-abrasion and pressure on tablets Signup and view all the answers

What is the purpose of the disintegration test in quality control of tablets?

To identify the time required for a tablet to break up into particles Signup and view all the answers

What is necessary for a drug to be absorbed?

The drug must be dissolved in fluids at the absorption site Signup and view all the answers

What is capping in tablet processing?

The separation of the upper or lower segment of a tablet from the main body Signup and view all the answers

What is the purpose of quality control tests in tablet manufacturing?

To ensure the quality of tablets during production and storage Signup and view all the answers

Study Notes

Types of Tablets

Multiple compressed tablets (Layered Tablets)
Compressed Coated Tablet: composed of a core tablet and inert material
Sugar-coated tablets: composed of a core tablet and sugar coating layers
Film-coated tablets: composed of a core tablet and film coating layer
Enteric coated tablets: composed of a core tablet and film coating layer
Buccal or sublingual tablets
Chewable tablets
Effervescent tablets
Lozenges
Implants
Sustained Release Tablets

Dosage Form Design

Physicochemical properties of the drug: reactivity, stability, solubility, acid/base, solid state behavior
Biopharmaceutical considerations: intended site of action, absorption, onset of action
Questions to consider:
- About the drug: aqueous solubility, pKa, partition coefficient, chemical stability in solution
- About the dosage form: dissolution characteristics, transdermal characteristics, stability in storage
- About the biopharmaceutics: extent of absorption, first-pass metabolism, intended use: topical vs. systemic

Coating Materials

Protect tablet ingredients from deterioration by moisture
Help with swallowing unpleasant-tasting tablets
Examples of coating materials: hydroxypropylmethyl cellulose (HPMC), synthetic polymers, shellac, corn protein zein, polysaccharides
Plasticizers: produce elasticity and flexibility to the coating materials, determine hardness of capsule shell, impart softness and resilience to suppositories
Flavors: limited to chewable tablets, mask unpleasant taste

Excipients Selection

Excipients are indispensable components of medicinal products
Selection is based on characteristics: functionality, material consistency, regulatory acceptance, cost, availability, sources, interaction with AI, other excipients, and packaging

Wet Granulation

Process involves dry mixing, wet mixing, granulation, drying, and quality control
Machines used: mixer, wet granulator, dryer
Quality control: moisture content

Tablet Machine

Types: single punch press, rotary punch press
Single punch tablet press: simplest machine for tablet manufacturing, employs a single tooling station, available as both manually operated and power driven
Rotary tablet press: multi-station tablet press, rotates the head of the machine that holds the upper punches, dies, and lower punches in place

Auxiliary Equipments

Granulation feeding device: forces granules into die cavity to avoid weight variation and content uniformity
Tablet weight monitoring devices: continuous tablet weight monitoring with electronic devices
Tablet deduster: removes excess powder on tablet surface
Fette machine: chills compression components to compress low melting point substances like waxes

Quality Control of Tablets

Uniformity of weight
Uniformity of diameter
Uniformity of thickness
Hardness test: related to tablet strength and ability to withstand shocks and frictions
Friability test: measures ability of tablets to withstand friction, pressure, and shock
Disintegration test: measures time required for tablet to break up and particles to pass through a 10 mesh screen
Dissolution test: measures rate of drug dissolution in fluid at the absorption site

Tablet Processing Problems and Remedies

Capping: upper or lower segment of the tablet separates horizontally during ejection from tablet press or subsequent handling

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Description

This quiz covers different types of tablets in pharmacy, including compressed coated, sugar-coated, film-coated, and enteric coated tablets.