17 Questions
What are the diagnostic criteria for chronic idiopathic constipation (CIC)?
Symptoms for ≥ 6 months and ≥ 2 of the listed symptoms
Which of the following is an example of an agent that causes softening of feces in 1-3 days?
Methylcellulose
What is the role of Lactulose in the treatment of constipation?
It increases stool frequency by reaching the large bowel
Which agent causes watery evacuation within 1-6 hours?
Bisacodyl
What lifestyle changes are recommended in the initial management for chronic idiopathic constipation?
Increasing fluid intake
Which medication is classified as an osmotic laxative?
Lactulose
What is the typical administration schedule for the oral solution mentioned in the text?
Once daily
Which side effect is specifically mentioned in relation to Miralax and lactulose in the text?
Flatulence
When should stimulant laxatives like bisacodyl or senna be used according to the text?
Occasional use or rescue therapy
What would be the next step if fiber is partially effective or not effective at all according to the treatment pearls in the text?
Add an osmotic laxative for 2-4 weeks
What is a key monitoring consideration highlighted in the text regarding long-term use of specific medications?
Monitor for electrolyte imbalance
What are the treatment goals mentioned in the text for managing constipation?
Relieve symptoms and re-establish normal bowel habits
What is the MOA of Prucalopride (Motegrity)?
It is a GI prokinetic agent that stimulates colonic peristalsis
In the 12-week studies, how many bowel movements per week did patients need to have, on average, with Prucalopride (Motegrity)?
At least 3 bowel movements per week
What is a contraindication for using Prucalopride (Motegrity)?
Crohn's disease
How should Prucalopride (Motegrity) be administered?
Orally once daily, with or without food
What side effect should patients using Prucalopride (Motegrity) watch out for?
Headache
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