Constipation: Guidance for Quizzes and Exams
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Questions and Answers

What are the criteria for diagnosing chronic idiopathic constipation (CIC)?

  • Symptoms for ≥ 6 months and ≥ 2 specific symptoms for > 25% of defecations during the past 3 months (correct)
  • Symptoms for ≥ 6 months and no history of prior constipation
  • Symptoms for ≥ 6 months with severe abdominal pain
  • Symptoms for ≥ 3 months and any combination of symptoms related to defecation

    • What is the initial management strategy recommended for chronic idiopathic constipation?

  • Intravenous administration of magnesium sulfate
  • Increasing fiber, fluids, and physical activity (correct)
  • Immediate use of osmotic laxatives
  • Long-term use of stimulant laxatives

    • Which agent results in soft or semi-fluid stool within 6-12 hours?

  • Bisacodyl (correct)
  • Lactulose
  • Methylcellulose
  • Polyethylene glycol

    • How does Lactulose exert its laxative effect?

    <p>By being metabolized by colonic bacteria to monosaccharides</p> Signup and view all the answers

    Which type of agent causes watery evacuation within 1-6 hours?

    <p>Sodium phosphates</p> Signup and view all the answers

    What class of agents are Lubiprostone, Linaclotide, Plecanatide, and Prucalopride classified as?

    <p>Intestinal secretagogues</p> Signup and view all the answers

    What is the recommended first-line treatment for mild chronic idiopathic constipation (CIC) according to the text?

    <p>Fiber</p> Signup and view all the answers

    What side effect is commonly associated with Miralax and lactulose as mentioned in the text?

    <p>Flatulence</p> Signup and view all the answers

    When should stimulant laxatives like bisacodyl or senna be used for chronic idiopathic constipation (CIC) according to the text?

    <p>For occasional use or rescue therapy</p> Signup and view all the answers

    What should be monitored periodically if an osmotic laxative is used for more than 6 months according to the text?

    <p>Electrolyte imbalance</p> Signup and view all the answers

    In a patient who cannot move, drink plenty of fluids, or has difficulty swallowing, what type of laxatives should be avoided according to the text?

    <p>Bulk laxatives</p> Signup and view all the answers

    If fiber is ineffective for a patient with mild chronic idiopathic constipation (CIC), what is the recommended next step according to the text?

    <p>Add an osmotic laxative for 2-4 weeks</p> Signup and view all the answers

    What is the mechanism of action of Prucalopride (Motegrity)?

    <p>Stimulates colonic peristalsis</p> Signup and view all the answers

    How often is Prucalopride (Motegrity) administered?

    <p>Orally once daily</p> Signup and view all the answers

    What is the average number of bowel movements per week expected in patients taking Prucalopride (Motegrity) during 12-week studies?

    <p>Exactly 3 BMs per week</p> Signup and view all the answers

    Which of the following is a common side effect of Prucalopride (Motegrity)?

    <p>Headache</p> Signup and view all the answers

    What condition is a contraindication for the use of Prucalopride (Motegrity)?

    <p>Crohn’s disease</p> Signup and view all the answers

    When should a lower dose of Prucalopride (Motegrity) be considered?

    <p>If creatinine clearance (CrCL) is below 30 mL/min</p> Signup and view all the answers

    Which medication could be classified as an OTC option for constipation?

    <p>(Miralax)</p> Signup and view all the answers

    If a Patient has tried Miralax and its not effective, lactulose be the next line of therapy

    <p>False</p> Signup and view all the answers

    The only prokinetic agents used in Constipation

    <p>Prucalopride</p> Signup and view all the answers

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