Constipation: Guidance for Quizzes and Exams
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Questions and Answers

What are the criteria for diagnosing chronic idiopathic constipation (CIC)?

  • Symptoms for ≥ 6 months and ≥ 2 specific symptoms for > 25% of defecations during the past 3 months (correct)
  • Symptoms for ≥ 6 months and no history of prior constipation
  • Symptoms for ≥ 6 months with severe abdominal pain
  • Symptoms for ≥ 3 months and any combination of symptoms related to defecation

What is the initial management strategy recommended for chronic idiopathic constipation?

  • Intravenous administration of magnesium sulfate
  • Increasing fiber, fluids, and physical activity (correct)
  • Immediate use of osmotic laxatives
  • Long-term use of stimulant laxatives

Which agent results in soft or semi-fluid stool within 6-12 hours?

  • Bisacodyl (correct)
  • Lactulose
  • Methylcellulose
  • Polyethylene glycol

How does Lactulose exert its laxative effect?

<p>By being metabolized by colonic bacteria to monosaccharides (A)</p> Signup and view all the answers

Which type of agent causes watery evacuation within 1-6 hours?

<p>Sodium phosphates (D)</p> Signup and view all the answers

What class of agents are Lubiprostone, Linaclotide, Plecanatide, and Prucalopride classified as?

<p>Intestinal secretagogues (C)</p> Signup and view all the answers

What is the recommended first-line treatment for mild chronic idiopathic constipation (CIC) according to the text?

<p>Fiber (C)</p> Signup and view all the answers

What side effect is commonly associated with Miralax and lactulose as mentioned in the text?

<p>Flatulence (A)</p> Signup and view all the answers

When should stimulant laxatives like bisacodyl or senna be used for chronic idiopathic constipation (CIC) according to the text?

<p>For occasional use or rescue therapy (D)</p> Signup and view all the answers

What should be monitored periodically if an osmotic laxative is used for more than 6 months according to the text?

<p>Electrolyte imbalance (B)</p> Signup and view all the answers

In a patient who cannot move, drink plenty of fluids, or has difficulty swallowing, what type of laxatives should be avoided according to the text?

<p>Bulk laxatives (A)</p> Signup and view all the answers

If fiber is ineffective for a patient with mild chronic idiopathic constipation (CIC), what is the recommended next step according to the text?

<p>Add an osmotic laxative for 2-4 weeks (B)</p> Signup and view all the answers

What is the mechanism of action of Prucalopride (Motegrity)?

<p>Stimulates colonic peristalsis (B)</p> Signup and view all the answers

How often is Prucalopride (Motegrity) administered?

<p>Orally once daily (B)</p> Signup and view all the answers

What is the average number of bowel movements per week expected in patients taking Prucalopride (Motegrity) during 12-week studies?

<p>Exactly 3 BMs per week (B)</p> Signup and view all the answers

Which of the following is a common side effect of Prucalopride (Motegrity)?

<p>Headache (A)</p> Signup and view all the answers

What condition is a contraindication for the use of Prucalopride (Motegrity)?

<p>Crohn’s disease (A)</p> Signup and view all the answers

When should a lower dose of Prucalopride (Motegrity) be considered?

<p>If creatinine clearance (CrCL) is below 30 mL/min (D)</p> Signup and view all the answers

Which medication could be classified as an OTC option for constipation?

<p>(Miralax) (A)</p> Signup and view all the answers

If a Patient has tried Miralax and its not effective, lactulose be the next line of therapy

<p>False (B)</p> Signup and view all the answers

The only prokinetic agents used in Constipation

<p>Prucalopride (A)</p> Signup and view all the answers

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