21 Questions
What are the criteria for diagnosing chronic idiopathic constipation (CIC)?
Symptoms for ≥ 6 months and ≥ 2 specific symptoms for > 25% of defecations during the past 3 months
What is the initial management strategy recommended for chronic idiopathic constipation?
Increasing fiber, fluids, and physical activity
Which agent results in soft or semi-fluid stool within 6-12 hours?
Bisacodyl
How does Lactulose exert its laxative effect?
By being metabolized by colonic bacteria to monosaccharides
Which type of agent causes watery evacuation within 1-6 hours?
Sodium phosphates
What class of agents are Lubiprostone, Linaclotide, Plecanatide, and Prucalopride classified as?
Intestinal secretagogues
What is the recommended first-line treatment for mild chronic idiopathic constipation (CIC) according to the text?
Fiber
What side effect is commonly associated with Miralax and lactulose as mentioned in the text?
Flatulence
When should stimulant laxatives like bisacodyl or senna be used for chronic idiopathic constipation (CIC) according to the text?
For occasional use or rescue therapy
What should be monitored periodically if an osmotic laxative is used for more than 6 months according to the text?
Electrolyte imbalance
In a patient who cannot move, drink plenty of fluids, or has difficulty swallowing, what type of laxatives should be avoided according to the text?
Bulk laxatives
If fiber is ineffective for a patient with mild chronic idiopathic constipation (CIC), what is the recommended next step according to the text?
Add an osmotic laxative for 2-4 weeks
What is the mechanism of action of Prucalopride (Motegrity)?
Stimulates colonic peristalsis
How often is Prucalopride (Motegrity) administered?
Orally once daily
What is the average number of bowel movements per week expected in patients taking Prucalopride (Motegrity) during 12-week studies?
Exactly 3 BMs per week
Which of the following is a common side effect of Prucalopride (Motegrity)?
Headache
What condition is a contraindication for the use of Prucalopride (Motegrity)?
Crohn’s disease
When should a lower dose of Prucalopride (Motegrity) be considered?
If creatinine clearance (CrCL) is below 30 mL/min
Which medication could be classified as an OTC option for constipation?
(Miralax)
If a Patient has tried Miralax and its not effective, lactulose be the next line of therapy
False
The only prokinetic agents used in Constipation
Prucalopride
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