Pharmacy Lecture: Sepsis and Septic Shock
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Questions and Answers

What laboratory tests should be performed to evaluate infection or complications of sepsis?

  • Arterial blood gas, comprehensive metabolic panel, and coagulation parameters
  • CBC with differential and comprehensive metabolic panel
  • Imaging studies, serum lactate, and complete blood count
  • Complete Blood Count with differential, coagulation parameters, comprehensive metabolic panel, serum lactate, and arterial blood gas (correct)

What is the hallmark treatment of septic shock?

  • Vasopressor therapy and fluid resuscitation
  • Intravenous hydrocortisone administration and vasopressor therapy
  • Early administration of broad-spectrum antimicrobial therapy
  • Rapid antibiotic administration and fluid resuscitation (correct)

What is the primary goal of fluid therapy in septic shock?

  • To optimize perfusion of vital organs
  • To maintain hemodynamic stability
  • To restore intravascular volume depletion (correct)
  • To reduce blood pressure

What is the recommended first-line fluid for resuscitation in septic shock?

<p>Crystalloids (C)</p> Signup and view all the answers

What is the suggested target for glycemic control in septic shock?

<p>Glucose levels between 140 and 180 mg/dL (C)</p> Signup and view all the answers

When should vasopressors be used in septic shock?

<p>After restoration of intravascular volume (B)</p> Signup and view all the answers

What is the recommended initial dose of crystalloid for hypotension or lactate ≥4 mmol/L?

<p>30 mL/kg balanced crystalloid (D)</p> Signup and view all the answers

What is the suggested fluid in patients who received large volumes of crystalloids?

<p>Albumin (D)</p> Signup and view all the answers

When should intravenous hydrocortisone be considered in septic shock?

<p>In patients who remain hemodynamically unstable despite adequate fluid resuscitation and vasopressor support (A)</p> Signup and view all the answers

What is the target mean arterial pressure (MAP) in patients with septic shock refractory to fluid resuscitation?

<p>MAP of 65 mmHg (B)</p> Signup and view all the answers

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