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Pharmacy Lecture: Sepsis and Septic Shock

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Pharmacy Lecture: Sepsis and Septic Shock

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Questions and Answers

What laboratory tests should be performed to evaluate infection or complications of sepsis?

Arterial blood gas, comprehensive metabolic panel, and coagulation parameters

CBC with differential and comprehensive metabolic panel

Imaging studies, serum lactate, and complete blood count

Complete Blood Count with differential, coagulation parameters, comprehensive metabolic panel, serum lactate, and arterial blood gas (correct)

What is the hallmark treatment of septic shock?

Vasopressor therapy and fluid resuscitation

Intravenous hydrocortisone administration and vasopressor therapy

Early administration of broad-spectrum antimicrobial therapy

Rapid antibiotic administration and fluid resuscitation (correct)

What is the primary goal of fluid therapy in septic shock?

To optimize perfusion of vital organs

To maintain hemodynamic stability

To restore intravascular volume depletion (correct)

To reduce blood pressure

What is the recommended first-line fluid for resuscitation in septic shock?

Crystalloids Signup and view all the answers

What is the suggested target for glycemic control in septic shock?

Glucose levels between 140 and 180 mg/dL Signup and view all the answers

When should vasopressors be used in septic shock?

After restoration of intravascular volume Signup and view all the answers

What is the recommended initial dose of crystalloid for hypotension or lactate ≥4 mmol/L?

30 mL/kg balanced crystalloid Signup and view all the answers

What is the suggested fluid in patients who received large volumes of crystalloids?

Albumin Signup and view all the answers

When should intravenous hydrocortisone be considered in septic shock?

In patients who remain hemodynamically unstable despite adequate fluid resuscitation and vasopressor support Signup and view all the answers

What is the target mean arterial pressure (MAP) in patients with septic shock refractory to fluid resuscitation?

MAP of 65 mmHg Signup and view all the answers