Pharmacy: GI Drugs and Reflux Mechanism
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Pharmacy: GI Drugs and Reflux Mechanism

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Questions and Answers

What is the primary function of Urease enzyme secreted by pylori?

  • Inhibit cell wall synthesis
  • Convert ammonia to urea
  • Destroy nucleic acid
  • Neutralize stomach acid (correct)
  • What is the mechanism of action of Clarithromycin?

  • Inhibits protein synthesis (correct)
  • Disrupts cell wall synthesis
  • Has an antibiotic effect
  • Inhibits nucleic acid destruction
  • What is the purpose of Sucralfate in the treatment of ulcers?

  • To destroy nucleic acid
  • To act as a local antiulcer agent (correct)
  • To disrupt cell wall synthesis
  • To inhibit protein synthesis
  • What is the effect of Laxatives on the intestine?

    <p>Increase secretion of fluids</p> Signup and view all the answers

    What is the primary goal of treatment for ulcers?

    <p>Relieve symptoms and improve quality of life</p> Signup and view all the answers

    What is the mechanism of action of Misoprostol?

    <p>Exhibits both antisecretory and cytoprotectant effects</p> Signup and view all the answers

    What happens when the lower esophageal sphincter weakens?

    <p>Acid refluxes into the esophagus</p> Signup and view all the answers

    What is the primary function of the enteric nervous system?

    <p>To control cravings and mood</p> Signup and view all the answers

    What is the role of somatostatin in the stomach?

    <p>To inhibit the release of gastric acid</p> Signup and view all the answers

    What is a common misconception about ulcers?

    <p>They are permanent and cannot be healed</p> Signup and view all the answers

    What is the term for the erosion or ulceration of the mucosal lining of the gastrointestinal tract?

    <p>Acid-peptic disease</p> Signup and view all the answers

    What is the purpose of the hydrogen potassium pump/proton pump in the stomach?

    <p>To pump out H+ ions to form gastric acid</p> Signup and view all the answers

    What is the primary location of ulcerative colitis in the gastrointestinal tract?

    <p>Rectum and colon</p> Signup and view all the answers

    What is the term for the formation of abscesses in the crypts of Lieberkuhn?

    <p>Abscess formation</p> Signup and view all the answers

    Which of the following medications is used to treat constipation-predominant IBS?

    <p>Mesapride</p> Signup and view all the answers

    What is the percentage of patients with ulcerative colitis who have extensive colitis (pancolitis)?

    <p>14% - 35%</p> Signup and view all the answers

    What is the reason for diarrhea and bleeding in ulcerative colitis?

    <p>Mucosal damage and friability of the colon</p> Signup and view all the answers

    What is the term for the inflammation of a short segment of the terminal ileum in ulcerative colitis?

    <p>Backwash ileitis</p> Signup and view all the answers

    What is the effect of involvement of muscularis propria in the GI tract?

    <p>Loss of tonic tone and potential dilation</p> Signup and view all the answers

    What is the most common site of Crohn's disease?

    <p>Ileum</p> Signup and view all the answers

    What is the characteristic appearance of ulcers in Crohn's disease?

    <p>Deep and elongated</p> Signup and view all the answers

    What is a potential complication of Crohn's disease?

    <p>Small bowel stricture and obstruction</p> Signup and view all the answers

    What is the mechanism of action of Methotrexate in IBD?

    <p>Anti-metabolite</p> Signup and view all the answers

    What is the function of Natalizumab in IBD treatment?

    <p>Inhibiting leukocyte adhesion and migration</p> Signup and view all the answers

    What is the role of budesonide in treating patients with moderate extensive disease?

    <p>Alternative to oral 5-ASA products</p> Signup and view all the answers

    For which patients is infliximab + azathioprine often used?

    <p>Those with moderate to severe active UC</p> Signup and view all the answers

    What is the advantage of vedolizumab?

    <p>It can be used as an alternative to TNF-a inhibitors</p> Signup and view all the answers

    Why are oral sulfasalazine or mesalamine derivatives not typically beneficial in severe disease?

    <p>They are rapidly eliminated from the colon due to diarrhea</p> Signup and view all the answers

    What is the role of systemic corticosteroids in treating UC?

    <p>They are often used in the treatment of moderate to severe active UC</p> Signup and view all the answers

    What is the goal of using infliximab + azathioprine in patients with acute severe colitis?

    <p>To induce corticosteroid-free remission</p> Signup and view all the answers

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