Gastrointestinal Pharmacology: Stomach Anatomy and Function

Play an AI-generated podcast conversation about this lesson

What is the primary mechanism by which H. pylori bacteria attach to the epithelial cells of the stomach and duodenum?

Through adherence to the epithelial cells (correct)
By initiating a self-destructive immune response
Through direct contact with contaminated food or water
By secreting degradative enzymes

What is the purpose of Bismuth in H. pylori treatment?

To disrupt the bacterial cell wall (correct)
To stimulate the production of degradative enzymes
To inhibit protein synthesis
To initiate a self-destructive immune response

What is the primary advantage of using Metronidazole in H. pylori treatment?

It is less likely to cause antibiotic resistance
It is often used due to bacterial resistance to Amoxicillin and Tetracycline (correct)
It is more effective than Amoxicillin in disrupting the bacterial cell wall
It stimulates the production of degradative enzymes

What is the effectiveness of Triple Therapy in treating H. pylori infections?

80-85% (D) Signup and view all the answers

What is the primary mechanism of action of Clarithromycin in H. pylori treatment?

Inhibiting protein synthesis (C) Signup and view all the answers

What is the primary mode of transmission of H. pylori infections?

Direct contact with saliva, vomit, or stool (B) Signup and view all the answers

What is the purpose of the Proton pump inhibitor in H. pylori treatment?

To reduce acid production and create an environment conducive to antibiotic activity (B) Signup and view all the answers

What percentage of Peptic Ulcer Disease (PUD) is caused by H. pylori?

80-85% (B) Signup and view all the answers

What is the primary disadvantage of using Pylori repeatedly or for more than 2 months at a time?

It can cause black stools and constipation (A) Signup and view all the answers

What is the advantage of Quadruple Therapy over Triple Therapy in treating H. pylori infections?

It is as efficacious as Triple Therapy but with a shorter treatment duration (C) Signup and view all the answers

What is the name of the condition that is linked to cancer of the esophagus and is characterized by the need for monitoring?

Barrett's Esophagus (D) Signup and view all the answers

What is the primary function of gastric rugae?

To increase the surface area for nutrient absorption (C) Signup and view all the answers

What is the primary mechanism of action of H2 receptor blockers?

Competitive inhibition of histamine H2 receptors (B) Signup and view all the answers

Which type of cells are responsible for the production of mucus in the stomach lining?

Mucous cells (A) Signup and view all the answers

What is the role of histamine in the production of gastric acid?

It aids in the release of histamine from ECL cells (D) Signup and view all the answers

Which of the following antacids is contraindicated in patients with impaired renal function?

Aluminum hydroxide + magnesium hydroxide (D) Signup and view all the answers

What is the minimum antacid neutralizing capacity (ANC) required by the FDA per dose?

5 meq (C) Signup and view all the answers

Where are G-cells primarily located in the stomach?

Pyloric antrum (D) Signup and view all the answers

What is the function of delta (D) cells in the gastrointestinal tract?

To inhibit the production of acid in the stomach (B) Signup and view all the answers

Which of the following proton pump inhibitors was removed from the market by the FDA due to concerns about its potential to cause cancer?

Ranitidine (C) Signup and view all the answers

What is the mechanism of action of misoprostol?

Stimulating prostaglandin E1 receptors on parietal cells (C) Signup and view all the answers

What is the primary function of enterochromaffin (EC) cells in the stomach?

To release serotonin (D) Signup and view all the answers

What is the primary indication for the use of pirenzepine?

Adjunct therapy for NSAID-induced injury (C) Signup and view all the answers

What is the purpose of the gastric mucosal barrier in the stomach?

To protect the epithelium from harsh acid conditions (C) Signup and view all the answers

What is the primary symptom of gastroesophageal reflux disease (GERD)?

Heartburn (B) Signup and view all the answers

What is the mechanism of action of sucralfate?

Forming a protective barrier on the ulcer site (B) Signup and view all the answers

Which of the following is a common side effect of misoprostol?

Diarrhea (C) Signup and view all the answers

What is a potential complication of GERD?

Esophageal ulcer (C) Signup and view all the answers

What is the primary mechanism of action of proton pump inhibitors?

Inhibiting the production of gastric acid through the irreversible inhibition of proton pumps (D) Signup and view all the answers

What is the abnormal epithelium that replaces the normal esophageal lining in some patients with GERD?

Barrett's epithelium (D) Signup and view all the answers