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Gastrointestinal Pharmacology: Inflammatory Bowel Disease

Test your knowledge of gastrointestinal pharmacology, focusing on inflammatory bowel disease, including ulcerative colitis and Crohn's disease, their symptoms, and treatment options. Learn about the therapeutics used to resolve acute episodes and prolong remission.

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Questions and Answers

What is the primary location of mucosal inflammation in ulcerative colitis?

Colon

Which of the following medications is used for active and chronic symptoms of inflammatory bowel disease, but has significant side effects?

Cyclosporin

What is the mechanism of action of corticosteroids in inflammatory bowel disease?

Inhibition of inflammatory pathways

Which of the following medications is a prodrug of 5-aminosalicylic acid?

<p>Balsalazide</p> Signup and view all the answers

What is the primary effect of thiopurines in inflammatory bowel disease?

<p>Induction of T cell apoptosis</p> Signup and view all the answers

Which of the following medications is used for relapsing or active Crohn's disease refractory or intolerant to azathioprine or thiopurine?

<p>Methotrexate</p> Signup and view all the answers

What is the primary effect of infliximab in inflammatory bowel disease?

<p>Antibody infusion</p> Signup and view all the answers

What is the potential long-term benefit of aminosalicylates in inflammatory bowel disease?

<p>Reduced risk of colorectal cancer</p> Signup and view all the answers

What is the primary mechanism of action of Infliximab?

<p>Blocking the activity of TNF-α</p> Signup and view all the answers

What is the main side effect of bulking agents that can occur if not taken with sufficient water?

<p>Worsening of constipation</p> Signup and view all the answers

Which of the following is a major side effect of chronic steroid use?

<p>Renal impairment</p> Signup and view all the answers

What is the primary indication for the use of Infliximab in Crohn's disease?

<p>Fistulizing disease</p> Signup and view all the answers

What is the primary mechanism of action of osmotic laxatives?

<p>Inhibiting the absorption of water and electrolytes</p> Signup and view all the answers

What is the most common cause of constipation in patients who abuse laxatives?

<p>Laxative abuse</p> Signup and view all the answers

What is the primary advantage of bulking agents over other types of laxatives?

<p>Long-term safety</p> Signup and view all the answers

Which of the following is a common side effect of Infliximab infusion?

<p>Infusion reactions</p> Signup and view all the answers

What is the primary mechanism of action of lactulose?

<p>Breaking down into acetic and lactic acid, causing an osmotic effect</p> Signup and view all the answers

What is the effect of enteral loss of water and salts on potassium levels?

<p>It decreases potassium levels by increasing renal excretion of potassium</p> Signup and view all the answers

What is the primary mechanism of action of docusate sodium?

<p>Lubricating and softening the consistency of the stool</p> Signup and view all the answers

What is the effect of laxative abuse on the colon?

<p>It leads to a vicious cycle of constipation and repeated use</p> Signup and view all the answers

What is the primary mechanism of action of lubiprostone?

<p>Stimulating the release of chloride channels in the intestinal mucosa</p> Signup and view all the answers

What is the effect of aldosterone on potassium levels?

<p>It decreases potassium levels by stimulating the reabsorption of sodium</p> Signup and view all the answers

What is the primary mechanism of action of bisacodyl?

<p>Irritating the GI mucosa and increasing intestinal motility</p> Signup and view all the answers

What is the effect of osmotic force on the bowel?

<p>It increases the volume of the bowel and triggers peristalsis</p> Signup and view all the answers

What is often misinterpreted as constipation?

<p>Diarrhea</p> Signup and view all the answers

What is the primary cause of antibiotic-associated diarrhea?

<p>Clostridium difficile</p> Signup and view all the answers

Which of the following anti-diarrheal agents reduces peristalsis and increases intestinal transit time?

<p>Loperamide</p> Signup and view all the answers

What is the purpose of atropine in combination with diphenoxylate?

<p>To prevent drug abuse</p> Signup and view all the answers

What is the consequence of altering the normal fecal flora in the colon?

<p>Colonic colonization of C. difficile</p> Signup and view all the answers

What is the role of toxin A and toxin B in C. difficile infection?

<p>They produce a toxin that causes diarrhea</p> Signup and view all the answers

What is the indication for treatment in elderly or small children with diarrhea?

<p>Severe diarrhea lasting more than 2-3 days</p> Signup and view all the answers

What is the contraindication for Loperamide use?

<p>Toxic colitis/megacolon</p> Signup and view all the answers

Which antibiotic is contraindicated in patients with liver or renal impairment, and is used to treat infection that can lead to colitis and toxic megacolon?

<p>Metronidazole</p> Signup and view all the answers

What is the mechanism of action of Simethicone in relieving painful symptoms associated with gas?

<p>Alters elasticity of mucus-coated bubbles</p> Signup and view all the answers

Which area of the brain is responsible for stimulating emesis, and is also known as the chemoreceptor trigger zone?

<p>Area postrema</p> Signup and view all the answers

What is the mechanism of action of Scopolamine as an antiemetic?

<p>Muscarinic M1 receptor antagonist</p> Signup and view all the answers

What is the primary side effect of Phenothiazines as antiemetics?

<p>Extrapyramidal effects</p> Signup and view all the answers

Which antiemetic is used to treat chemotherapy-induced nausea and vomiting, and has a mechanism of action that involves antagonism of serotonin 5-HT3 receptors?

<p>Ondansetron</p> Signup and view all the answers

What is the primary contraindication for the use of Metoclopramide as an antiemetic?

<p>Parkinson's disease</p> Signup and view all the answers

Which antiemetic has central anticholinergic actions, and is used to treat benign paroxysmal positional vertigo (BPPV)?

<p>Meclizine</p> Signup and view all the answers

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