Podcast
Questions and Answers
What is the primary mechanism of action for 5-Fluorouracil (5-FU) in cancer treatment?
What is the primary mechanism of action for 5-Fluorouracil (5-FU) in cancer treatment?
Besides inhibiting TS, through which other mechanism does 5-FU exert its anticancer effects?
Besides inhibiting TS, through which other mechanism does 5-FU exert its anticancer effects?
Which of the following is a key active metabolite of 5-Fluorouracil (5-FU)?
Which of the following is a key active metabolite of 5-Fluorouracil (5-FU)?
Where does the extensive metabolism of 5-FU primarily occur in the body?
Where does the extensive metabolism of 5-FU primarily occur in the body?
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What is the mechanism by which capecitabine, a prodrug of 5-FU, is activated?
What is the mechanism by which capecitabine, a prodrug of 5-FU, is activated?
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Study Notes
5-Fluorouracil (5-FU)
- Widely used, particularly for colorectal cancer
- 5-FU inhibits thymidylate synthase (TS)
- 5-FU incorporates its metabolites into RNA and DNA
- 5-FU is converted to active metabolites, including Fluoro-deoxyuridine monophosphate (FdUMP)
- 5-FU is extensively metabolised in the gut and liver
- 5-FU prodrugs, like Capecitabine, are developed for oral administration
- Capecitabine is activated by a cascade of 3 enzymes into 5-FU
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Description
This quiz covers the key aspects of 5-Fluorouracil (5-FU), a crucial chemotherapy drug used primarily for colorectal cancer. Explore its mechanism of action, metabolism, and the development of oral prodrugs like Capecitabine. Test your knowledge on how 5-FU and its metabolites function in cancer treatment.
