Podcast
Questions and Answers
How does 5-Fluorouracil interfere with cellular processes?
How does 5-Fluorouracil interfere with cellular processes?
- By promoting DNA synthesis
- By enhancing thymidine production
- By inhibiting the conversion of deoxyuridylic acid to thymidylic acid (correct)
- By increasing the rate of cell division
What is the role of thymidine in cellular processes?
What is the role of thymidine in cellular processes?
- Acting as a precursor for DNA synthesis (correct)
- Serving as a signaling molecule
- Promoting cell division
- Enhancing protein synthesis
In which type of tumors is 5-Fluorouracil primarily used for treatment?
In which type of tumors is 5-Fluorouracil primarily used for treatment?
- Slow-growing solid tumors (correct)
- Lung carcinomas
- Blood cancers
- Fast-growing solid tumors
What is the effect of topically applied 5-Fluorouracil on superficial basal cell carcinomas?
What is the effect of topically applied 5-Fluorouracil on superficial basal cell carcinomas?
Why is the fluorine atom in 5-Fluorouracil significant?
Why is the fluorine atom in 5-Fluorouracil significant?
Why is it important to keep the urine alkaline and the patient well hydrated when administering methotrexate?
Why is it important to keep the urine alkaline and the patient well hydrated when administering methotrexate?
Which route of administration can be used for methotrexate besides the oral route?
Which route of administration can be used for methotrexate besides the oral route?
Why should pemetrexed and pralatrexate be given with folic acid and vitamin B12 supplements?
Why should pemetrexed and pralatrexate be given with folic acid and vitamin B12 supplements?
What adverse effect is associated with pemetrexed that necessitates pretreatment with corticosteroids?
What adverse effect is associated with pemetrexed that necessitates pretreatment with corticosteroids?
Which category do drugs like 6-mercaptopurine and fludarabine belong to?
Which category do drugs like 6-mercaptopurine and fludarabine belong to?
Why are some drugs in the purine analogs category used as immunosuppressants and antivirals instead of for cancer chemotherapy?
Why are some drugs in the purine analogs category used as immunosuppressants and antivirals instead of for cancer chemotherapy?
Which chemotherapeutic agent is a pyrimidine analog with a stable fluorine atom at position 5 of the uracil ring?
Which chemotherapeutic agent is a pyrimidine analog with a stable fluorine atom at position 5 of the uracil ring?
What is the primary mechanism of action of 6-Mercaptopurine (6-MP) in the treatment of neoplastic diseases?
What is the primary mechanism of action of 6-Mercaptopurine (6-MP) in the treatment of neoplastic diseases?
Which enzyme initially phosphorylates Fludarabine to its active form in cells?
Which enzyme initially phosphorylates Fludarabine to its active form in cells?
What is the main target of thymidine inhibitors among chemotherapeutic agents?
What is the main target of thymidine inhibitors among chemotherapeutic agents?
Why is Fludarabine administered intravenously rather than orally?
Why is Fludarabine administered intravenously rather than orally?
Which chemotherapeutic agent is used in the maintenance of remission in acute lymphoblastic leukemia?
Which chemotherapeutic agent is used in the maintenance of remission in acute lymphoblastic leukemia?
