Recent Lessons

Show all results for ""

Feature Overview

Ace your exams with our all-in-one platform for creating and sharing quizzes and tests.

Quizzes

Create quizzes and tests automatically from your content using AI.

Flashcards

Automatically turn your notes into digital flashcards.

Share, Export & Embed

Share with classmates or export to Excel and your learning management system.

Stats & Reporting

Auto-grading quizzes and tests with detailed stats and reports.

Mobile Apps

The smarter way to study – wherever you are.

Pricing

Search...

5-Fluorouracil (5-FU) Pyrimidine Analog Mechanism and Clinical Applications

17 Questions

0 Views

5-Fluorouracil (5-FU) Pyrimidine Analog Mechanism and Clinical Applications

Choose a study mode

Play Quiz

Study Flashcards

Spaced Repetition

Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

How does 5-Fluorouracil interfere with cellular processes?

By promoting DNA synthesis

By enhancing thymidine production

By inhibiting the conversion of deoxyuridylic acid to thymidylic acid (correct)

By increasing the rate of cell division

What is the role of thymidine in cellular processes?

Acting as a precursor for DNA synthesis (correct)

Serving as a signaling molecule

Promoting cell division

Enhancing protein synthesis

In which type of tumors is 5-Fluorouracil primarily used for treatment?

Slow-growing solid tumors (correct)

Lung carcinomas

Blood cancers

Fast-growing solid tumors

What is the effect of topically applied 5-Fluorouracil on superficial basal cell carcinomas?

It is effective for treatment Signup and view all the answers

Why is the fluorine atom in 5-Fluorouracil significant?

It interferes with the conversion of deoxyuridylic acid to thymidylic acid Signup and view all the answers

Why is it important to keep the urine alkaline and the patient well hydrated when administering methotrexate?

To reduce the risk of renal toxicity due to 7-hydroxymethotrexate Signup and view all the answers

Which route of administration can be used for methotrexate besides the oral route?

Subcutaneous Signup and view all the answers

Why should pemetrexed and pralatrexate be given with folic acid and vitamin B12 supplements?

To reduce hematologic and GI toxicities Signup and view all the answers

What adverse effect is associated with pemetrexed that necessitates pretreatment with corticosteroids?

Ocular toxicity Signup and view all the answers

Which category do drugs like 6-mercaptopurine and fludarabine belong to?

Antimetabolites Signup and view all the answers

Why are some drugs in the purine analogs category used as immunosuppressants and antivirals instead of for cancer chemotherapy?

As they have immunosuppressive and antiviral actions Signup and view all the answers

Which chemotherapeutic agent is a pyrimidine analog with a stable fluorine atom at position 5 of the uracil ring?

Capecitabine Signup and view all the answers

What is the primary mechanism of action of 6-Mercaptopurine (6-MP) in the treatment of neoplastic diseases?

Inhibiting purine nucleotide synthesis Signup and view all the answers

Which enzyme initially phosphorylates Fludarabine to its active form in cells?

Deoxycytidine kinase Signup and view all the answers

What is the main target of thymidine inhibitors among chemotherapeutic agents?

Pyrimidine nucleotide synthesis Signup and view all the answers

Why is Fludarabine administered intravenously rather than orally?

To avoid toxic metabolite formation in the intestine Signup and view all the answers

Which chemotherapeutic agent is used in the maintenance of remission in acute lymphoblastic leukemia?

6-Mercaptopurine (6-MP) Signup and view all the answers