12 Questions
What is the primary reason Leucovorin is administered with 5 FU?
To inhibit thymidylate synthase
Where is 5 FU metabolized rapidly?
Liver
What can elevated levels of dihydropyrimidine dehydrogenase (DPD) lead to?
Decreased 5-FU catabolism
Which enzyme is responsible for the hydrolysis of capecitabine to 5FU?
An unknown enzyme
In which phase of the cell cycle does 5 FU produce its anticancer effect?
S phase
What can happen to patients with DPD deficiency when treated with 5-FU?
Severe toxicity manifested by pancytopenia and mucositis
What is the main cytotoxic activity of capecitabine and 5-FU?
Inhibition of thymidylate synthase
Which enzyme is primarily concentrated in tumors and catalyzes the conversion of thymidine?
Thymidine phosphorylase
What is the major clinical use of cytarabine?
Acute nonlymphocytic leukemia (AML)
Which metabolite of cytarabine is pharmacologically inactive?
Ara-U
How does azacitidine primarily inhibit RNA processing and function?
Incorporation into RNA
Which phase of the cell cycle is affected by Ara-CTP, the active form of cytarabine?
S phase
Test your knowledge on the pharmacology of 5-Fluorouracil (5-FU), including its administration with Leucovorin, mechanism of action involving thymidylate synthase inhibition, and pharmacokinetics such as administration routes and effects on the cell cycle.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
