18 Questions
What is a common side effect of first-generation antihistamines?
Decreased airway smooth muscle contraction
Which drug is slow in onset and nearly free of side effects?
Inhaled ipratropium
Why has theophylline been largely replaced by β2-agonists and corticosteroids in asthma therapy?
Narrow therapeutic window
What does Omalizumab selectively bind to?
Immunoglobulin E (IgE)
Which medication is useful in patients who cannot tolerate adrenergic agonists?
Inhaled ipratropium
What is a limitation of using theophylline in asthma therapy?
High side-effect profile
Which type of therapy is considered the first-line treatment for allergic rhinitis?
Oral antihistamines with decongestants
What prompted interest in the topical intranasal delivery of drugs for allergic rhinitis?
Systemic effects of oral preparations
Which of the following is a common side effect of first-generation antihistamines?
Transient anticholinergic side effects
What is the primary function of codeine in cough suppression?
Decreasing sensitivity of cough centers in the CNS
Which type of drugs have prompted interest in the topical intranasal delivery of medications for allergic rhinitis?
First-generation antihistamines
What symptom may require treatment with a stool softener when associated with chronic use of first-generation antihistamines?
Constipation
What is the main adverse effect of zafirlukast and montelukast that requires periodic monitoring?
Elevations in serum hepatic enzymes
What is a common adverse effect associated with the use of cromolyn for asthma?
Irritation of the pharynx and larynx
Which drugs are effective prophylactic anti-inflammatory agents but not useful in managing acute asthma attacks?
Cromolyn and nedocromil
What are the main side effects of using cromolyn for reducing allergic rhinitis symptoms?
Bitter taste and irritation of the pharynx
Which drugs are selective, reversible inhibitors of the cysteinyl leukotriene-1 receptor?
Zafirlukast and zileuton
What is a common adverse effect of anticholinergic agents like cromolyn and nedocromil?
Bitter taste and pharynx irritation
Test your knowledge on Zafirlukast and Montelukast, selective inhibitors of the cysteinyl leukotriene-1 receptor. Learn about their mechanism of action, market leadership, and adverse effects on serum hepatic enzymes.
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