Podcast
Questions and Answers
What is the primary function of the blood pressure in the human body?
What is the primary function of the blood pressure in the human body?
What is measured during blood pressure measurement?
What is measured during blood pressure measurement?
Which of the following is NOT a factor affecting blood pressure?
Which of the following is NOT a factor affecting blood pressure?
What is the equation that relates blood pressure to its contributing factors?
What is the equation that relates blood pressure to its contributing factors?
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What is the term for the volume of blood pumped by each ventricle in one contraction?
What is the term for the volume of blood pumped by each ventricle in one contraction?
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Which division of the autonomic nervous system has a significant impact on blood pressure?
Which division of the autonomic nervous system has a significant impact on blood pressure?
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What is the unit of measurement for blood pressure?
What is the unit of measurement for blood pressure?
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What is the purpose of the right atrium in the context of blood pressure?
What is the purpose of the right atrium in the context of blood pressure?
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What is the effect of sympathetic nerves on blood vessels?
What is the effect of sympathetic nerves on blood vessels?
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What is the function of baroreceptors in large arteries?
What is the function of baroreceptors in large arteries?
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What is the effect of exercise and stress on blood vessels?
What is the effect of exercise and stress on blood vessels?
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What is the role of the kidneys in regulating blood pressure?
What is the role of the kidneys in regulating blood pressure?
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What is the effect of diuretics on blood pressure?
What is the effect of diuretics on blood pressure?
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What happens when arterial blood pressure falls?
What happens when arterial blood pressure falls?
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What is the effect of angiotensin II on blood vessels?
What is the effect of angiotensin II on blood vessels?
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What is the effect of heat on blood vessels?
What is the effect of heat on blood vessels?
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What is the function of the renin-angiotensin-aldosterone system (RAAS)?
What is the function of the renin-angiotensin-aldosterone system (RAAS)?
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What is the effect of β-blockers on blood pressure?
What is the effect of β-blockers on blood pressure?
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What is the effect of epinephrine on the body?
What is the effect of epinephrine on the body?
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Why should people with hypertension quit smoking?
Why should people with hypertension quit smoking?
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What is the effect of alcohol on blood vessels?
What is the effect of alcohol on blood vessels?
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What is the primary mechanism by which diuretics lower blood pressure?
What is the primary mechanism by which diuretics lower blood pressure?
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Which of the following is a class of antihypertensive drugs that acts on the renin-angiotensin-aldosterone system?
Which of the following is a class of antihypertensive drugs that acts on the renin-angiotensin-aldosterone system?
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What is the mechanism of action of thiazide diuretics?
What is the mechanism of action of thiazide diuretics?
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What is the effect of loop diuretics on renal blood flow?
What is the effect of loop diuretics on renal blood flow?
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What is the equation that relates blood pressure to cardiac output and peripheral resistance?
What is the equation that relates blood pressure to cardiac output and peripheral resistance?
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What is the effect of baroreflexes on blood pressure?
What is the effect of baroreflexes on blood pressure?
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What is the primary mechanism by which β-blockers lower blood pressure?
What is the primary mechanism by which β-blockers lower blood pressure?
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What is the result of propranolol's negative inotropic and chronotropic effects on the heart?
What is the result of propranolol's negative inotropic and chronotropic effects on the heart?
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Why must β-blockers be tapered over a few weeks in patients with hypertension and ischemic heart disease?
Why must β-blockers be tapered over a few weeks in patients with hypertension and ischemic heart disease?
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What is the therapeutic use of propranolol in addition to hypertension?
What is the therapeutic use of propranolol in addition to hypertension?
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What is the receptor specificity of nebivolol?
What is the receptor specificity of nebivolol?
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What is the effect of β-blockers on heart rate during exercise or stress?
What is the effect of β-blockers on heart rate during exercise or stress?
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Which of the following β-adrenergic antagonists is a selective β1 receptor blocker?
Which of the following β-adrenergic antagonists is a selective β1 receptor blocker?
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What is the effect of ACE inhibitors on blood pressure?
What is the effect of ACE inhibitors on blood pressure?
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What is a rare but potentially life-threatening reaction to ACE inhibitors?
What is a rare but potentially life-threatening reaction to ACE inhibitors?
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What is the therapeutic use of timolol?
What is the therapeutic use of timolol?
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What is the mechanism of action of ACE inhibitors?
What is the mechanism of action of ACE inhibitors?
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What is the primary mechanism of action of potassium-sparing diuretics?
What is the primary mechanism of action of potassium-sparing diuretics?
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Which of the following diuretics is an aldosterone receptor antagonist?
Which of the following diuretics is an aldosterone receptor antagonist?
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What is the primary effect of β-blockers on the cardiovascular system?
What is the primary effect of β-blockers on the cardiovascular system?
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What is the primary mechanism of action of thiazide diuretics?
What is the primary mechanism of action of thiazide diuretics?
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Which of the following β-blockers is a selective blocker of β1-receptors?
Which of the following β-blockers is a selective blocker of β1-receptors?
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What is the primary effect of nonselective β-blockers on the lungs?
What is the primary effect of nonselective β-blockers on the lungs?
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What is the primary effect of β-blockers on the renin-angiotensin-aldosterone system?
What is the primary effect of β-blockers on the renin-angiotensin-aldosterone system?
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What is a common adverse effect of β-blockers?
What is a common adverse effect of β-blockers?
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Which of the following diuretics is often used in combination with loop diuretics and thiazides?
Which of the following diuretics is often used in combination with loop diuretics and thiazides?
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What is the primary effect of noncardioselective β-blockers on serum lipid patterns?
What is the primary effect of noncardioselective β-blockers on serum lipid patterns?
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Which of the following is a renin inhibitor?
Which of the following is a renin inhibitor?
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What is the main effect of calcium channel blockers on blood vessels?
What is the main effect of calcium channel blockers on blood vessels?
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Which of the following angiotensin II receptor blockers is available in the form of medoxomil?
Which of the following angiotensin II receptor blockers is available in the form of medoxomil?
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What is the common side effect of verapamil?
What is the common side effect of verapamil?
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What is the effect of α1-adrenoceptor blockers on blood vessels?
What is the effect of α1-adrenoceptor blockers on blood vessels?
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Which of the following drugs is suitable for pregnant women with hypertension?
Which of the following drugs is suitable for pregnant women with hypertension?
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What is the effect of clonidine on blood pressure?
What is the effect of clonidine on blood pressure?
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What is the common side effect of dihydropyridines?
What is the common side effect of dihydropyridines?
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What is the effect of methyldopa on the body?
What is the effect of methyldopa on the body?
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Which of the following drugs is used in the treatment of heart failure?
Which of the following drugs is used in the treatment of heart failure?
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What is the direction of blood flow in the body?
What is the direction of blood flow in the body?
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What is the term for the pressure in the arteries when the ventricles are relaxing?
What is the term for the pressure in the arteries when the ventricles are relaxing?
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Which of the following factors increases peripheral resistance?
Which of the following factors increases peripheral resistance?
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What happens to blood pressure when the kidneys retain body water?
What happens to blood pressure when the kidneys retain body water?
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What is the equation that relates blood pressure to its contributing factors?
What is the equation that relates blood pressure to its contributing factors?
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What is the autonomic nervous system division that plays a significant role in blood pressure regulation?
What is the autonomic nervous system division that plays a significant role in blood pressure regulation?
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What is the effect of angiotensin II on blood vessels?
What is the effect of angiotensin II on blood vessels?
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What is the unit of measurement for blood pressure?
What is the unit of measurement for blood pressure?
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What is the role of baroreceptors in large arteries?
What is the role of baroreceptors in large arteries?
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What is the term for the amount of blood pumped out of the left ventricle per minute?
What is the term for the amount of blood pumped out of the left ventricle per minute?
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What is the effect of diuretics on blood volume?
What is the effect of diuretics on blood volume?
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What is the factor that determines the amount of blood pumped by each ventricle in one contraction?
What is the factor that determines the amount of blood pumped by each ventricle in one contraction?
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What is the effect of sympathetic nervous system on cardiac output?
What is the effect of sympathetic nervous system on cardiac output?
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What is the role of renin in the renin-angiotensin-aldosterone system?
What is the role of renin in the renin-angiotensin-aldosterone system?
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What is the effect of heat on blood vessels?
What is the effect of heat on blood vessels?
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What is the effect of β-blockers on blood pressure?
What is the effect of β-blockers on blood pressure?
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What is the role of the kidneys in regulating blood pressure?
What is the role of the kidneys in regulating blood pressure?
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What is the effect of cold on blood vessels?
What is the effect of cold on blood vessels?
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Which of the following substances increases blood pressure by causing vasoconstriction?
Which of the following substances increases blood pressure by causing vasoconstriction?
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What is the effect of diuretics on stroke volume?
What is the effect of diuretics on stroke volume?
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Which of the following is a class of antihypertensive drugs that acts on the renin-angiotensin-aldosterone system?
Which of the following is a class of antihypertensive drugs that acts on the renin-angiotensin-aldosterone system?
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What is the primary mechanism by which thiazide diuretics lower blood pressure?
What is the primary mechanism by which thiazide diuretics lower blood pressure?
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What is the effect of loop diuretics on renal blood flow?
What is the effect of loop diuretics on renal blood flow?
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Which of the following is a mechanism by which baroreflexes regulate blood pressure?
Which of the following is a mechanism by which baroreflexes regulate blood pressure?
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What is the effect of β-blockers on heart rate?
What is the effect of β-blockers on heart rate?
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What is the effect of vasodilators on peripheral resistance?
What is the effect of vasodilators on peripheral resistance?
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Which of the following substances causes vasodilation and decreases blood pressure?
Which of the following substances causes vasodilation and decreases blood pressure?
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What is the primary mechanism by which ACE inhibitors lower blood pressure?
What is the primary mechanism by which ACE inhibitors lower blood pressure?
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What is the primary function of potassium-sparing diuretics?
What is the primary function of potassium-sparing diuretics?
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Which of the following diuretics inhibits epithelial sodium transport at the late distal and collecting ducts?
Which of the following diuretics inhibits epithelial sodium transport at the late distal and collecting ducts?
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What is the mechanism of action of β-adrenoceptor blockers?
What is the mechanism of action of β-adrenoceptor blockers?
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Which of the following is a selective blocker of β1-receptors?
Which of the following is a selective blocker of β1-receptors?
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What is the effect of nonselective β-blockers on the lungs?
What is the effect of nonselective β-blockers on the lungs?
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What is the primary mechanism of action of thiazide diuretics?
What is the primary mechanism of action of thiazide diuretics?
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What is the effect of β-blockers on serum lipid patterns?
What is the effect of β-blockers on serum lipid patterns?
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Which of the following is an aldosterone receptor antagonist?
Which of the following is an aldosterone receptor antagonist?
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What is the primary effect of β-blockers on the cardiovascular system?
What is the primary effect of β-blockers on the cardiovascular system?
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Which of the following diuretics is often used in combination with loop diuretics and thiazides?
Which of the following diuretics is often used in combination with loop diuretics and thiazides?
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What is the effect of propranolol on cardiac output, workload, and oxygen consumption?
What is the effect of propranolol on cardiac output, workload, and oxygen consumption?
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What is the receptor specificity of carvedilol?
What is the receptor specificity of carvedilol?
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Why should β-blockers be tapered over a few weeks in patients with hypertension and ischemic heart disease?
Why should β-blockers be tapered over a few weeks in patients with hypertension and ischemic heart disease?
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What is the effect of ACE inhibitors on angiotensin II?
What is the effect of ACE inhibitors on angiotensin II?
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What is the therapeutic use of esmolol?
What is the therapeutic use of esmolol?
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What is the receptor specificity of atenolol?
What is the receptor specificity of atenolol?
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What is the effect of β-blockers on lipid metabolism?
What is the effect of β-blockers on lipid metabolism?
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What is the mechanism of action of angiotensin II receptor blockers?
What is the mechanism of action of angiotensin II receptor blockers?
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What is the therapeutic use of nebivolol?
What is the therapeutic use of nebivolol?
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What is the receptor specificity of labetalol?
What is the receptor specificity of labetalol?
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What is the mechanism of action of aliskiren?
What is the mechanism of action of aliskiren?
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Which of the following calcium channel blockers can cause gingival hyperplasia?
Which of the following calcium channel blockers can cause gingival hyperplasia?
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What is the effect of prazosin, doxazosin, and terazosin on peripheral vascular resistance?
What is the effect of prazosin, doxazosin, and terazosin on peripheral vascular resistance?
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Which of the following drugs is used in the treatment of heart failure?
Which of the following drugs is used in the treatment of heart failure?
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What is the mechanism of action of clonidine?
What is the mechanism of action of clonidine?
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Which of the following drugs is a dihydropyridine calcium channel blocker?
Which of the following drugs is a dihydropyridine calcium channel blocker?
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What is the effect of α1-adrenoceptor blocking agents on vasoconstriction?
What is the effect of α1-adrenoceptor blocking agents on vasoconstriction?
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What is the primary mechanism of action of methyldopa?
What is the primary mechanism of action of methyldopa?
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Which of the following drugs is a selective α1-adrenoceptor blocker?
Which of the following drugs is a selective α1-adrenoceptor blocker?
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What is a common adverse effect of dihydropyridine calcium channel blockers?
What is a common adverse effect of dihydropyridine calcium channel blockers?
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Study Notes
Definition of Terms
-
Blood Pressure: The pressure exerted by blood on the inner walls of blood vessels, keeping blood circulating between heartbeats.
- Measured in mm Hg (millimeters of mercury)
- Reported as systolic pressure (peak contraction) and diastolic pressure (relaxation)
Hydraulic Equation of Blood Pressure
-
BP = CO x PR
-
Cardiac Output (CO): Amount of blood pumped out of the left ventricle per minute
- Determined by Stroke Volume (SV) and Heart Rate (HR)
-
Peripheral Resistance (PR): Friction encountered by blood flowing through blood vessels
- Increased peripheral resistance increases blood pressure
-
Cardiac Output (CO): Amount of blood pumped out of the left ventricle per minute
Factors Affecting Blood Pressure
-
Neural Factors: Autonomic Nervous System
- Parasympathetic Division: Little or no effect on blood pressure
- Sympathetic Nerves: Cause vasoconstriction, increasing blood pressure
- B-blockers: Adrenergic antagonists that lower blood pressure
-
Renal Factors: The Kidneys
- Kidneys regulate arterial blood pressure by altering blood volume
- Diuretics: Stimulate kidneys to remove water from blood, decreasing blood volume and pressure
-
Temperature
- Cold: Vasoconstricting effect
- Heat: Vasodilating effect
-
Chemical Substances
- Epinephrine: Increases heart rate and blood pressure
- Nicotine: Causes vasoconstriction, increasing blood pressure
- Alcohol & Histamine: Cause vasodilation, decreasing blood pressure
-
Diet
- Low in salt, saturated fats, and cholesterol: Helps prevent hypertension
- Diuretics: Affect stroke volume
- B-blockers: Affect heart rate
- Vasodilators: Affect peripheral resistance
Mechanisms of Controlling Blood Pressure
- Hydraulic Equation of Blood Pressure: BP = CO x PR
-
Cardiac Output (CO) and Peripheral Resistance (PR): Controlled by overlapping mechanisms:
- Baroreflexes
- Renin-Angiotensin-Aldosterone System (RAAS)
Baroreflex
- Acts by changing sympathetic nervous system activity
- Rapid, moment-to-moment regulation of blood pressure
Renin-Angiotensin-Aldosterone System (RAAS)
- Stimulates renin release from kidneys
- Increases sodium and water retention, blood volume, and blood pressure
Different Classes of Antihypertensive Drugs
- Diuretics
- β-Adrenoceptor Blockers
- ACE (Angiotensin Converting Enzyme) Inhibitors
- Angiotensin II Receptor Blockers (ARB)
- Renin Inhibitor
- Calcium Channel Blockers
- α-Adrenoceptor Blocking Agents
- α-/β-Adrenoceptor Blocking Agents
- Centrally Acting Adrenergic Drugs
- Vasodilators
Diuretics
- Function: Lower blood pressure by depleting body sodium stores
- Mechanism: Act on stroke volume
-
Classes:
- Thiazide Diuretics
- Loop Diuretics
- Potassium-Sparing Diuretics
β-Adrenoceptor Blockers
- Function: Reduce blood pressure by decreasing cardiac output
- Mechanism: Block β1- and β2-receptors
-
Effects:
- Decrease heart rate
- Decrease renin release
- Reduce blood pressure by inhibiting renin-angiotensin-aldosterone system
-
Adverse Effects:
- Bradycardia
- Hypotension
- CNS side effects (fatigue, lethargy, insomnia)
- Decreased libido and erectile dysfunction
- Alterations in Serum Lipid Patterns: Noncardioselective β-blockers may disturb lipid metabolism
ACE (Angiotensin Converting Enzyme) Inhibitors
- Action: Lower blood pressure by reducing peripheral vascular resistance
- Mechanism: Block ACE, reducing angiotensin II formation
-
Adverse Effects:
- Dry cough
- Rash
- Fever
- Altered taste
- Hypotension
- Hyperkalemia
- Angioedema: Rare but potentially life-threatening reaction
Angiotensin II Receptor Blockers (ARB)
- Action: Lower blood pressure by reducing peripheral vascular resistance
- Mechanism: Block AT1 receptors, decreasing angiotensin II activation
- Adverse Effects: Similar to ACE inhibitors, but with reduced risk of cough and angioedema
Renin Inhibitor
- Action: Directly inhibits renin, reducing angiotensin II formation
- Mechanism: Acts earlier in the renin-angiotensin-aldosterone system than ACE inhibitors or ARBs
- Adverse Effects: Diarrhea, cough, and angioedema (less frequent than ACE inhibitors)
Calcium Channel Blockers
- Action: Lower blood pressure by relaxing vascular smooth muscle
- Mechanism: Block L-type calcium channels in the heart and smooth muscle
-
Adverse Effects:
- Dizziness
- Headache
- Fatigue
- Peripheral edema
- Gingival hyperplasia (dihydropyridines)
α-Adrenoceptor Blocking Agents
-
Action: Lower blood pressure by blocking α1-adrenoceptors
-
Mechanism: Relax both arterial and venous smooth muscle
-
Adverse Effects:
- Dizziness
- Headache
- Fatigue
- Orthostatic hypotension### Inhibition of α1 Binding
-
Inhibition of α1 binding leads to decreased vasoconstriction, decreased peripheral resistance (PR), and decreased blood pressure (BP)
-
α1 binding is blocked by prazosin, doxazosin, or terazosin, which prevents norepinephrine (NE) and epinephrine (E) binding
Adverse Effects
- Reflex tachycardia and postural hypotension often occur at the onset of treatment and with dose increases, requiring slow titration of the drug in divided doses
- Orthostatic hypotension leads to low blood pressure and lightheadedness upon standing up
α-/β-Adrenoceptor Blocking Agents
- Labetalol and Carvedilol block α1, β1, and β2 receptors
- Not suitable for patients with asthma
- Carvedilol is an effective antihypertensive, used in the treatment of heart failure
- Labetalol is used in the management of gestational hypertension and hypertensive emergencies, and is suitable for pregnant women
- Carvedilol, Metoprolol Succinate, and Bisoprolol have been shown to reduce morbidity and mortality associated with heart failure
Centrally Acting Adrenergic Drugs
- Clonidine acts centrally as an α2-agonist, decreasing sympathetic outflow to the periphery
- Clonidine is used for hypertension complicated by renal disease
- Methyldopa is converted to methyl norepinephrine centrally, diminishing adrenergic outflow from the CNS
- Methyldopa is commonly associated with sedation and drowsiness, and has limited use due to adverse effects and the need for multiple daily doses
- Methyldopa is mainly used for hypertension in pregnancy due to its safety record
Vasodilators
- Vasodilators act by producing relaxation of vascular smooth muscle, primarily in arteries and arterioles
Additional Information
- Hydralazine and Minoxidil are not used as primary drugs to treat hypertension
- Hydralazine is administered with a β-blocker and a diuretic
- Minoxidil is used to treat hypertrochosis (growth of body hair) and is used topically for male pattern baldness
Definition of Terms
-
Blood Pressure: The pressure exerted by blood on the inner walls of blood vessels, keeping blood circulating between heartbeats.
- Measured in mm Hg (millimeters of mercury)
- Reported as systolic pressure (peak contraction) and diastolic pressure (relaxation)
Hydraulic Equation of Blood Pressure
-
BP = CO x PR
-
Cardiac Output (CO): Amount of blood pumped out of the left ventricle per minute
- Determined by Stroke Volume (SV) and Heart Rate (HR)
-
Peripheral Resistance (PR): Friction encountered by blood flowing through blood vessels
- Increased peripheral resistance increases blood pressure
-
Cardiac Output (CO): Amount of blood pumped out of the left ventricle per minute
Factors Affecting Blood Pressure
-
Neural Factors: Autonomic Nervous System
- Parasympathetic Division: Little or no effect on blood pressure
- Sympathetic Nerves: Cause vasoconstriction, increasing blood pressure
- B-blockers: Adrenergic antagonists that lower blood pressure
-
Renal Factors: The Kidneys
- Kidneys regulate arterial blood pressure by altering blood volume
- Diuretics: Stimulate kidneys to remove water from blood, decreasing blood volume and pressure
-
Temperature
- Cold: Vasoconstricting effect
- Heat: Vasodilating effect
-
Chemical Substances
- Epinephrine: Increases heart rate and blood pressure
- Nicotine: Causes vasoconstriction, increasing blood pressure
- Alcohol & Histamine: Cause vasodilation, decreasing blood pressure
-
Diet
- Low in salt, saturated fats, and cholesterol: Helps prevent hypertension
- Diuretics: Affect stroke volume
- B-blockers: Affect heart rate
- Vasodilators: Affect peripheral resistance
Mechanisms of Controlling Blood Pressure
- Hydraulic Equation of Blood Pressure: BP = CO x PR
-
Cardiac Output (CO) and Peripheral Resistance (PR): Controlled by overlapping mechanisms:
- Baroreflexes
- Renin-Angiotensin-Aldosterone System (RAAS)
Baroreflex
- Acts by changing sympathetic nervous system activity
- Rapid, moment-to-moment regulation of blood pressure
Renin-Angiotensin-Aldosterone System (RAAS)
- Stimulates renin release from kidneys
- Increases sodium and water retention, blood volume, and blood pressure
Different Classes of Antihypertensive Drugs
- Diuretics
- β-Adrenoceptor Blockers
- ACE (Angiotensin Converting Enzyme) Inhibitors
- Angiotensin II Receptor Blockers (ARB)
- Renin Inhibitor
- Calcium Channel Blockers
- α-Adrenoceptor Blocking Agents
- α-/β-Adrenoceptor Blocking Agents
- Centrally Acting Adrenergic Drugs
- Vasodilators
Diuretics
- Function: Lower blood pressure by depleting body sodium stores
- Mechanism: Act on stroke volume
-
Classes:
- Thiazide Diuretics
- Loop Diuretics
- Potassium-Sparing Diuretics
β-Adrenoceptor Blockers
- Function: Reduce blood pressure by decreasing cardiac output
- Mechanism: Block β1- and β2-receptors
-
Effects:
- Decrease heart rate
- Decrease renin release
- Reduce blood pressure by inhibiting renin-angiotensin-aldosterone system
-
Adverse Effects:
- Bradycardia
- Hypotension
- CNS side effects (fatigue, lethargy, insomnia)
- Decreased libido and erectile dysfunction
- Alterations in Serum Lipid Patterns: Noncardioselective β-blockers may disturb lipid metabolism
ACE (Angiotensin Converting Enzyme) Inhibitors
- Action: Lower blood pressure by reducing peripheral vascular resistance
- Mechanism: Block ACE, reducing angiotensin II formation
-
Adverse Effects:
- Dry cough
- Rash
- Fever
- Altered taste
- Hypotension
- Hyperkalemia
- Angioedema: Rare but potentially life-threatening reaction
Angiotensin II Receptor Blockers (ARB)
- Action: Lower blood pressure by reducing peripheral vascular resistance
- Mechanism: Block AT1 receptors, decreasing angiotensin II activation
- Adverse Effects: Similar to ACE inhibitors, but with reduced risk of cough and angioedema
Renin Inhibitor
- Action: Directly inhibits renin, reducing angiotensin II formation
- Mechanism: Acts earlier in the renin-angiotensin-aldosterone system than ACE inhibitors or ARBs
- Adverse Effects: Diarrhea, cough, and angioedema (less frequent than ACE inhibitors)
Calcium Channel Blockers
- Action: Lower blood pressure by relaxing vascular smooth muscle
- Mechanism: Block L-type calcium channels in the heart and smooth muscle
-
Adverse Effects:
- Dizziness
- Headache
- Fatigue
- Peripheral edema
- Gingival hyperplasia (dihydropyridines)
α-Adrenoceptor Blocking Agents
-
Action: Lower blood pressure by blocking α1-adrenoceptors
-
Mechanism: Relax both arterial and venous smooth muscle
-
Adverse Effects:
- Dizziness
- Headache
- Fatigue
- Orthostatic hypotension### Inhibition of α1 Binding
-
Inhibition of α1 binding leads to decreased vasoconstriction, decreased peripheral resistance (PR), and decreased blood pressure (BP)
-
α1 binding is blocked by prazosin, doxazosin, or terazosin, which prevents norepinephrine (NE) and epinephrine (E) binding
Adverse Effects
- Reflex tachycardia and postural hypotension often occur at the onset of treatment and with dose increases, requiring slow titration of the drug in divided doses
- Orthostatic hypotension leads to low blood pressure and lightheadedness upon standing up
α-/β-Adrenoceptor Blocking Agents
- Labetalol and Carvedilol block α1, β1, and β2 receptors
- Not suitable for patients with asthma
- Carvedilol is an effective antihypertensive, used in the treatment of heart failure
- Labetalol is used in the management of gestational hypertension and hypertensive emergencies, and is suitable for pregnant women
- Carvedilol, Metoprolol Succinate, and Bisoprolol have been shown to reduce morbidity and mortality associated with heart failure
Centrally Acting Adrenergic Drugs
- Clonidine acts centrally as an α2-agonist, decreasing sympathetic outflow to the periphery
- Clonidine is used for hypertension complicated by renal disease
- Methyldopa is converted to methyl norepinephrine centrally, diminishing adrenergic outflow from the CNS
- Methyldopa is commonly associated with sedation and drowsiness, and has limited use due to adverse effects and the need for multiple daily doses
- Methyldopa is mainly used for hypertension in pregnancy due to its safety record
Vasodilators
- Vasodilators act by producing relaxation of vascular smooth muscle, primarily in arteries and arterioles
Additional Information
- Hydralazine and Minoxidil are not used as primary drugs to treat hypertension
- Hydralazine is administered with a β-blocker and a diuretic
- Minoxidil is used to treat hypertrochosis (growth of body hair) and is used topically for male pattern baldness
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Description
This quiz covers the basics of antihypertensive drugs, including the definition of blood pressure, measuring blood pressure, and systolic pressure.