40 Questions
Which adverse effect is associated with nilutamide?
Visual problems
Why is carboplatin preferred over cisplatin in some cases?
Lower toxicity
What is the mechanism of action of platinum coordination complex drugs like cisplatin?
They form inter- and intrastrand cross-links with DNA
In addition to carboplatin, what other platinum coordination complex drug is mentioned for colorectal cancer treatment?
Oxaliplatin
Which tumor type is NOT mentioned as an indication for cisplatin use?
Breast carcinoma
What rare adverse effect has been associated with flutamide use?
Liver failure
What is the primary mechanism by which tamoxifen prevents estrogen stimulation of breast cancer cells?
Competing with estrogen for intracellular receptors
How is the removal of hormonal stimuli from hormonedependent tumors typically accomplished?
Surgery
What specific type of tumor regresses following treatment with a specific hormone?
Hormone dependent
Which class of drugs is used in breast cancer treatment to prevent estrogen stimulation of cancer cells?
Aromatase inhibitors
What must a cell have in order for a steroid hormone to influence it?
Cytosolic receptors specific for that hormone
Which antiestrogen medication is mentioned to prevent estrogen stimulation of breast cancer cells?
Raloxifene
What is a distinct adverse effect of Oxaliplatin?
Cold-induced peripheral neuropathy
Which enzyme do topoisomerase inhibitors primarily inhibit?
Topoisomerase
Which drugs are considered first-line for treating breast cancer in postmenopausal women?
Anastrozole and letrozole
What is the mechanism of action of Camptothecins?
Inhibition of topoisomerase I
Which enzyme is involved in the hepatic metabolism of Exemestane?
CYP3A4
Which drug is used with 5-FU and leucovorin for the treatment of colorectal carcinoma?
Irinotecan
What are the major toxicities associated with Exemestane?
Nausea, fatigue, and hot flashes
What is the class of enzymes that reduce supercoiling of DNA?
Topoisomerases
Which hormones are primarily stimulated by Leuprolide, goserelin, and triptorelin?
Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH)
What is the active metabolite of Irinotecan that is potent in inhibiting topoisomerase I?
SN-38
How are Anastrozole and letrozole primarily excreted from the body?
Mainly in urine
What distinguishes Exemestane from Anastrozole and letrozole in terms of inhibition?
Exemestane is an irreversible inhibitor
How are monoclonal antibodies typically administered?
Intravenously
Which enzymes are targeted by tyrosine kinase inhibitors?
Tyrosine kinases
What is the main goal of immune checkpoint inhibitors?
Enhance the immune system's ability to attack tumors
What distinguishes monoclonal antibodies in terms of adverse effects compared to traditional chemotherapy agents?
They are directed at specific targets
How are tyrosine kinase inhibitors usually administered?
Orally
What is the mechanism of action of immune checkpoint inhibitors?
Enhancing immune system response against tumors
Which route of administration for bortezomib is associated with less neuropathy?
Subcutaneous
What is the recommended prophylaxis for patients receiving therapy with bortezomib?
Antiviral prophylaxis
Which drug has an adverse effect profile similar to bortezomib and is administered orally?
Ixazomib
What is a common adverse effect of carfilzomib administration?
Hypertension
Which type of tumors respond well to proteasome inhibition therapy?
Malignant tumors
What is a potential side effect of bortezomib therapy that may require antiviral prophylaxis?
Herpes zoster reactivation
Which adverse effect is commonly associated with carfilzomib use?
Hypertension
What is a notable gastrointestinal adverse effect shared by bortezomib and carfilzomib?
Diarrhea
What is a key reason why malignant cells respond well to proteasome inhibition?
Increased apoptosis resistance
What potential gastrointestinal issue may patients experience as an adverse effect of ixazomib, similar to bortezomib?
Diarrhea
Test your knowledge on steroid hormones and their antagonists with this quiz covering introduction, Tamoxifen, Fulvestrant, raloxifene, aromatase inhibitors, Leuprolide, goserelin, triptorelin, antiandrogens, platinum coordination complexes, topoisomerase inhibitors, etoposide, monoclonal antibodies, tyrosine kinase inhibitors, immunotherapy and more.
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