Steroid Hormones and Their Antagonists
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Steroid Hormones and Their Antagonists

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Questions and Answers

Which adverse effect is associated with nilutamide?

  • Nausea
  • Visual problems (correct)
  • Gynecomastia
  • Constipation

    • Why is carboplatin preferred over cisplatin in some cases?

  • Higher efficacy
  • Less drug interactions
  • Lower toxicity (correct)
  • Faster onset of action

    • What is the mechanism of action of platinum coordination complex drugs like cisplatin?

  • They block DNA replication
  • They inhibit protein synthesis
  • They target cell membranes
  • They form inter- and intrastrand cross-links with DNA (correct)

    • In addition to carboplatin, what other platinum coordination complex drug is mentioned for colorectal cancer treatment?

    <p>Oxaliplatin</p> Signup and view all the answers

    Which tumor type is NOT mentioned as an indication for cisplatin use?

    <p>Breast carcinoma</p> Signup and view all the answers

    What rare adverse effect has been associated with flutamide use?

    <p>Liver failure</p> Signup and view all the answers

    What is the primary mechanism by which tamoxifen prevents estrogen stimulation of breast cancer cells?

    <p>Competing with estrogen for intracellular receptors</p> Signup and view all the answers

    How is the removal of hormonal stimuli from hormonedependent tumors typically accomplished?

    <p>Surgery</p> Signup and view all the answers

    What specific type of tumor regresses following treatment with a specific hormone?

    <p>Hormone dependent</p> Signup and view all the answers

    Which class of drugs is used in breast cancer treatment to prevent estrogen stimulation of cancer cells?

    <p>Aromatase inhibitors</p> Signup and view all the answers

    What must a cell have in order for a steroid hormone to influence it?

    <p>Cytosolic receptors specific for that hormone</p> Signup and view all the answers

    Which antiestrogen medication is mentioned to prevent estrogen stimulation of breast cancer cells?

    <p>Raloxifene</p> Signup and view all the answers

    What is a distinct adverse effect of Oxaliplatin?

    <p>Cold-induced peripheral neuropathy</p> Signup and view all the answers

    Which enzyme do topoisomerase inhibitors primarily inhibit?

    <p>Topoisomerase</p> Signup and view all the answers

    Which drugs are considered first-line for treating breast cancer in postmenopausal women?

    <p>Anastrozole and letrozole</p> Signup and view all the answers

    What is the mechanism of action of Camptothecins?

    <p>Inhibition of topoisomerase I</p> Signup and view all the answers

    Which enzyme is involved in the hepatic metabolism of Exemestane?

    <p>CYP3A4</p> Signup and view all the answers

    Which drug is used with 5-FU and leucovorin for the treatment of colorectal carcinoma?

    <p>Irinotecan</p> Signup and view all the answers

    What are the major toxicities associated with Exemestane?

    <p>Nausea, fatigue, and hot flashes</p> Signup and view all the answers

    What is the class of enzymes that reduce supercoiling of DNA?

    <p>Topoisomerases</p> Signup and view all the answers

    Which hormones are primarily stimulated by Leuprolide, goserelin, and triptorelin?

    <p>Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH)</p> Signup and view all the answers

    What is the active metabolite of Irinotecan that is potent in inhibiting topoisomerase I?

    <p>SN-38</p> Signup and view all the answers

    How are Anastrozole and letrozole primarily excreted from the body?

    <p>Mainly in urine</p> Signup and view all the answers

    What distinguishes Exemestane from Anastrozole and letrozole in terms of inhibition?

    <p>Exemestane is an irreversible inhibitor</p> Signup and view all the answers

    How are monoclonal antibodies typically administered?

    <p>Intravenously</p> Signup and view all the answers

    Which enzymes are targeted by tyrosine kinase inhibitors?

    <p>Tyrosine kinases</p> Signup and view all the answers

    What is the main goal of immune checkpoint inhibitors?

    <p>Enhance the immune system's ability to attack tumors</p> Signup and view all the answers

    What distinguishes monoclonal antibodies in terms of adverse effects compared to traditional chemotherapy agents?

    <p>They are directed at specific targets</p> Signup and view all the answers

    How are tyrosine kinase inhibitors usually administered?

    <p>Orally</p> Signup and view all the answers

    What is the mechanism of action of immune checkpoint inhibitors?

    <p>Enhancing immune system response against tumors</p> Signup and view all the answers

    Which route of administration for bortezomib is associated with less neuropathy?

    <p>Subcutaneous</p> Signup and view all the answers

    What is the recommended prophylaxis for patients receiving therapy with bortezomib?

    <p>Antiviral prophylaxis</p> Signup and view all the answers

    Which drug has an adverse effect profile similar to bortezomib and is administered orally?

    <p>Ixazomib</p> Signup and view all the answers

    What is a common adverse effect of carfilzomib administration?

    <p>Hypertension</p> Signup and view all the answers

    Which type of tumors respond well to proteasome inhibition therapy?

    <p>Malignant tumors</p> Signup and view all the answers

    What is a potential side effect of bortezomib therapy that may require antiviral prophylaxis?

    <p>Herpes zoster reactivation</p> Signup and view all the answers

    Which adverse effect is commonly associated with carfilzomib use?

    <p>Hypertension</p> Signup and view all the answers

    What is a notable gastrointestinal adverse effect shared by bortezomib and carfilzomib?

    <p>Diarrhea</p> Signup and view all the answers

    What is a key reason why malignant cells respond well to proteasome inhibition?

    <p>Increased apoptosis resistance</p> Signup and view all the answers

    What potential gastrointestinal issue may patients experience as an adverse effect of ixazomib, similar to bortezomib?

    <p>Diarrhea</p> Signup and view all the answers

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