Podcast
Questions and Answers
Which adverse effect is associated with nilutamide?
Which adverse effect is associated with nilutamide?
- Nausea
- Visual problems (correct)
- Gynecomastia
- Constipation
Why is carboplatin preferred over cisplatin in some cases?
Why is carboplatin preferred over cisplatin in some cases?
- Higher efficacy
- Less drug interactions
- Lower toxicity (correct)
- Faster onset of action
What is the mechanism of action of platinum coordination complex drugs like cisplatin?
What is the mechanism of action of platinum coordination complex drugs like cisplatin?
- They block DNA replication
- They inhibit protein synthesis
- They target cell membranes
- They form inter- and intrastrand cross-links with DNA (correct)
In addition to carboplatin, what other platinum coordination complex drug is mentioned for colorectal cancer treatment?
In addition to carboplatin, what other platinum coordination complex drug is mentioned for colorectal cancer treatment?
Which tumor type is NOT mentioned as an indication for cisplatin use?
Which tumor type is NOT mentioned as an indication for cisplatin use?
What rare adverse effect has been associated with flutamide use?
What rare adverse effect has been associated with flutamide use?
What is the primary mechanism by which tamoxifen prevents estrogen stimulation of breast cancer cells?
What is the primary mechanism by which tamoxifen prevents estrogen stimulation of breast cancer cells?
How is the removal of hormonal stimuli from hormonedependent tumors typically accomplished?
How is the removal of hormonal stimuli from hormonedependent tumors typically accomplished?
What specific type of tumor regresses following treatment with a specific hormone?
What specific type of tumor regresses following treatment with a specific hormone?
Which class of drugs is used in breast cancer treatment to prevent estrogen stimulation of cancer cells?
Which class of drugs is used in breast cancer treatment to prevent estrogen stimulation of cancer cells?
What must a cell have in order for a steroid hormone to influence it?
What must a cell have in order for a steroid hormone to influence it?
Which antiestrogen medication is mentioned to prevent estrogen stimulation of breast cancer cells?
Which antiestrogen medication is mentioned to prevent estrogen stimulation of breast cancer cells?
What is a distinct adverse effect of Oxaliplatin?
What is a distinct adverse effect of Oxaliplatin?
Which enzyme do topoisomerase inhibitors primarily inhibit?
Which enzyme do topoisomerase inhibitors primarily inhibit?
Which drugs are considered first-line for treating breast cancer in postmenopausal women?
Which drugs are considered first-line for treating breast cancer in postmenopausal women?
What is the mechanism of action of Camptothecins?
What is the mechanism of action of Camptothecins?
Which enzyme is involved in the hepatic metabolism of Exemestane?
Which enzyme is involved in the hepatic metabolism of Exemestane?
Which drug is used with 5-FU and leucovorin for the treatment of colorectal carcinoma?
Which drug is used with 5-FU and leucovorin for the treatment of colorectal carcinoma?
What are the major toxicities associated with Exemestane?
What are the major toxicities associated with Exemestane?
What is the class of enzymes that reduce supercoiling of DNA?
What is the class of enzymes that reduce supercoiling of DNA?
Which hormones are primarily stimulated by Leuprolide, goserelin, and triptorelin?
Which hormones are primarily stimulated by Leuprolide, goserelin, and triptorelin?
What is the active metabolite of Irinotecan that is potent in inhibiting topoisomerase I?
What is the active metabolite of Irinotecan that is potent in inhibiting topoisomerase I?
How are Anastrozole and letrozole primarily excreted from the body?
How are Anastrozole and letrozole primarily excreted from the body?
What distinguishes Exemestane from Anastrozole and letrozole in terms of inhibition?
What distinguishes Exemestane from Anastrozole and letrozole in terms of inhibition?
How are monoclonal antibodies typically administered?
How are monoclonal antibodies typically administered?
Which enzymes are targeted by tyrosine kinase inhibitors?
Which enzymes are targeted by tyrosine kinase inhibitors?
What is the main goal of immune checkpoint inhibitors?
What is the main goal of immune checkpoint inhibitors?
What distinguishes monoclonal antibodies in terms of adverse effects compared to traditional chemotherapy agents?
What distinguishes monoclonal antibodies in terms of adverse effects compared to traditional chemotherapy agents?
How are tyrosine kinase inhibitors usually administered?
How are tyrosine kinase inhibitors usually administered?
What is the mechanism of action of immune checkpoint inhibitors?
What is the mechanism of action of immune checkpoint inhibitors?
Which route of administration for bortezomib is associated with less neuropathy?
Which route of administration for bortezomib is associated with less neuropathy?
What is the recommended prophylaxis for patients receiving therapy with bortezomib?
What is the recommended prophylaxis for patients receiving therapy with bortezomib?
Which drug has an adverse effect profile similar to bortezomib and is administered orally?
Which drug has an adverse effect profile similar to bortezomib and is administered orally?
What is a common adverse effect of carfilzomib administration?
What is a common adverse effect of carfilzomib administration?
Which type of tumors respond well to proteasome inhibition therapy?
Which type of tumors respond well to proteasome inhibition therapy?
What is a potential side effect of bortezomib therapy that may require antiviral prophylaxis?
What is a potential side effect of bortezomib therapy that may require antiviral prophylaxis?
Which adverse effect is commonly associated with carfilzomib use?
Which adverse effect is commonly associated with carfilzomib use?
What is a notable gastrointestinal adverse effect shared by bortezomib and carfilzomib?
What is a notable gastrointestinal adverse effect shared by bortezomib and carfilzomib?
What is a key reason why malignant cells respond well to proteasome inhibition?
What is a key reason why malignant cells respond well to proteasome inhibition?
What potential gastrointestinal issue may patients experience as an adverse effect of ixazomib, similar to bortezomib?
What potential gastrointestinal issue may patients experience as an adverse effect of ixazomib, similar to bortezomib?
