Steroid Hormones and Their Antagonists
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Steroid Hormones and Their Antagonists

Test your knowledge on steroid hormones and their antagonists with this quiz covering introduction, Tamoxifen, Fulvestrant, raloxifene, aromatase inhibitors, Leuprolide, goserelin, triptorelin, antiandrogens, platinum coordination complexes, topoisomerase inhibitors, etoposide, monoclonal antibodies, tyrosine kinase inhibitors, immunotherapy and more.

Created by
@RadiantHyena

Questions and Answers

Which adverse effect is associated with nilutamide?

Visual problems

Why is carboplatin preferred over cisplatin in some cases?

Lower toxicity

What is the mechanism of action of platinum coordination complex drugs like cisplatin?

They form inter- and intrastrand cross-links with DNA

In addition to carboplatin, what other platinum coordination complex drug is mentioned for colorectal cancer treatment?

<p>Oxaliplatin</p> Signup and view all the answers

Which tumor type is NOT mentioned as an indication for cisplatin use?

<p>Breast carcinoma</p> Signup and view all the answers

What rare adverse effect has been associated with flutamide use?

<p>Liver failure</p> Signup and view all the answers

What is the primary mechanism by which tamoxifen prevents estrogen stimulation of breast cancer cells?

<p>Competing with estrogen for intracellular receptors</p> Signup and view all the answers

How is the removal of hormonal stimuli from hormonedependent tumors typically accomplished?

<p>Surgery</p> Signup and view all the answers

What specific type of tumor regresses following treatment with a specific hormone?

<p>Hormone dependent</p> Signup and view all the answers

Which class of drugs is used in breast cancer treatment to prevent estrogen stimulation of cancer cells?

<p>Aromatase inhibitors</p> Signup and view all the answers

What must a cell have in order for a steroid hormone to influence it?

<p>Cytosolic receptors specific for that hormone</p> Signup and view all the answers

Which antiestrogen medication is mentioned to prevent estrogen stimulation of breast cancer cells?

<p>Raloxifene</p> Signup and view all the answers

What is a distinct adverse effect of Oxaliplatin?

<p>Cold-induced peripheral neuropathy</p> Signup and view all the answers

Which enzyme do topoisomerase inhibitors primarily inhibit?

<p>Topoisomerase</p> Signup and view all the answers

Which drugs are considered first-line for treating breast cancer in postmenopausal women?

<p>Anastrozole and letrozole</p> Signup and view all the answers

What is the mechanism of action of Camptothecins?

<p>Inhibition of topoisomerase I</p> Signup and view all the answers

Which enzyme is involved in the hepatic metabolism of Exemestane?

<p>CYP3A4</p> Signup and view all the answers

Which drug is used with 5-FU and leucovorin for the treatment of colorectal carcinoma?

<p>Irinotecan</p> Signup and view all the answers

What are the major toxicities associated with Exemestane?

<p>Nausea, fatigue, and hot flashes</p> Signup and view all the answers

What is the class of enzymes that reduce supercoiling of DNA?

<p>Topoisomerases</p> Signup and view all the answers

Which hormones are primarily stimulated by Leuprolide, goserelin, and triptorelin?

<p>Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH)</p> Signup and view all the answers

What is the active metabolite of Irinotecan that is potent in inhibiting topoisomerase I?

<p>SN-38</p> Signup and view all the answers

How are Anastrozole and letrozole primarily excreted from the body?

<p>Mainly in urine</p> Signup and view all the answers

What distinguishes Exemestane from Anastrozole and letrozole in terms of inhibition?

<p>Exemestane is an irreversible inhibitor</p> Signup and view all the answers

How are monoclonal antibodies typically administered?

<p>Intravenously</p> Signup and view all the answers

Which enzymes are targeted by tyrosine kinase inhibitors?

<p>Tyrosine kinases</p> Signup and view all the answers

What is the main goal of immune checkpoint inhibitors?

<p>Enhance the immune system's ability to attack tumors</p> Signup and view all the answers

What distinguishes monoclonal antibodies in terms of adverse effects compared to traditional chemotherapy agents?

<p>They are directed at specific targets</p> Signup and view all the answers

How are tyrosine kinase inhibitors usually administered?

<p>Orally</p> Signup and view all the answers

What is the mechanism of action of immune checkpoint inhibitors?

<p>Enhancing immune system response against tumors</p> Signup and view all the answers

Which route of administration for bortezomib is associated with less neuropathy?

<p>Subcutaneous</p> Signup and view all the answers

What is the recommended prophylaxis for patients receiving therapy with bortezomib?

<p>Antiviral prophylaxis</p> Signup and view all the answers

Which drug has an adverse effect profile similar to bortezomib and is administered orally?

<p>Ixazomib</p> Signup and view all the answers

What is a common adverse effect of carfilzomib administration?

<p>Hypertension</p> Signup and view all the answers

Which type of tumors respond well to proteasome inhibition therapy?

<p>Malignant tumors</p> Signup and view all the answers

What is a potential side effect of bortezomib therapy that may require antiviral prophylaxis?

<p>Herpes zoster reactivation</p> Signup and view all the answers

Which adverse effect is commonly associated with carfilzomib use?

<p>Hypertension</p> Signup and view all the answers

What is a notable gastrointestinal adverse effect shared by bortezomib and carfilzomib?

<p>Diarrhea</p> Signup and view all the answers

What is a key reason why malignant cells respond well to proteasome inhibition?

<p>Increased apoptosis resistance</p> Signup and view all the answers

What potential gastrointestinal issue may patients experience as an adverse effect of ixazomib, similar to bortezomib?

<p>Diarrhea</p> Signup and view all the answers

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