33 Questions
Which topic will be covered in lecture 3?
Androgens and anabolics
What is a key learning objective from today's lecture?
Steroid hormone structure and nomenclature
Which compound is specifically used for oral contraception?
17a-ethinylestradiol
What is a focus area for drugs targeting the estrogen receptor?
Breast cancer chemoprevention
Which steroid hormone is related to specificity and potency optimization through medicinal chemistry?
Hydrocortisone
What is a characteristic used to optimize the action of hydrocortisone (cortisol)?
Duration of action
Which lecture will delve into the medicinal chemistry of adrenocorticoids?
Lecture 4
What is the parent compound of steroids?
Cyclopentanoperhydrophenanthrene
Which of the following is not a type of steroids?
Insulin
What is the correct numbering of the fundamental saturated tetracyclic hydrocarbon skeleton?
ring A > B > C > D > C-18 > C-19 > side chain
What is the stereochemistry of cholestane?
cis-trans-trans
What is the configuration of androsterone?
trans-cis-trans
What is the principal bile salt?
Cholic acid
What is the stereochemistry of etiocholanolone?
trans-trans-trans
Who first isolated androsterone?
Johann Butenandt
What is the metabolic activity of cis-trans-trans etiocholanolone in urine?
Inactive metabolite with no androgenic activity
Which of the following statements about digitoxin is correct?
Digitoxin has a cis fusion between rings A/B and C/D, and a trans fusion between rings B/C
Which statement about batrachotoxin is incorrect?
Batrachotoxin contains a steroid ring system
Which statement about rocuronium's structure is correct?
Rocuronium has a trans-cis-cis ring fusion
Which of the following is a characteristic of the basic steroid structure?
The basic steroid structure is a plane with a bottom (a) surface and a top (b) surface
What is the metabolic activity of androsterone?
Androsterone is a neurosteroid with positive allosteric modulator activity on GABA A receptors
Which statement about etiocholanolone is correct?
Etiocholanolone is an inactive metabolite with no androgenic activity
Which of the following is a characteristic of 17a-estradiol?
17a-estradiol has an OH group at C17a
Which enzyme catalyzes the aromatization of androgens into estrogens?
Aromatase
What is the role of aromatase inhibitors in cancer treatment?
They suppress estrogen biosynthesis.
Which steroid compound has the systematic name 10-fluoro-11β,17,21-trihydroxy-16a methylpregna-1,4-diene-3,20-dione?
Dexamethasone
Which steroid hormone has the 17b-hydroxyandrost-4-en-3-one structure?
17b-hydroxyandrost-4-en-3-one
Which steroid hormone is correctly named 'estradiol'?
Estra-1,3,5-triene-3,17b-diol
Which steroid hormone has the structure 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione?
Cortisol
Which steroid hormone has the structure 3b-hydroxyandrost-5-en-17-one?
Testosterone
Which steroid hormone has the structure 17b-hydroxyandrost-4-en-3-one?
Testosterone
Which steroid hormone has the structure estra-1,3,5-triene-3,17b-diol?
Estradiol
Which steroid hormone has the structure 4-pregnene-3,20-dione?
Progesterone
This quiz covers the introduction lecture 1 of Medicinal Chemistry of Steroids in the PCOL 826B course, focusing on pages 1386-1433 in Foye’s Medicinal Chemistry. The lecture includes topics such as steroid hormone structure, nomenclature, stereochemistry, and endogenous estrogens.
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