Pharmacotherapy: Steroids and Sex Hormones
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Questions and Answers

What is a distinct feature of the 2-Dienogest progestin?

  • Has a C17 ethynyl group
  • Has a cyanomethyl group (correct)
  • Has a C21 hydroxyl group
  • Lacks the angular C19 methyl group

What is the effect of administrating 3-Elcometrine via subcutaneous (SC) versus oral route?

  • It is 100 times less potent when administered SC
  • It has the same potency when administered via both routes
  • It is 100 times more potent when administered SC (correct)
  • It is not absorbed when administered orally

Which progestin is similar to megestrol acetate but has better selectivity to the progesterone receptor?

  • 2-Dienogest
  • 4-Nomogestrol (correct)
  • 5-Trimegestrone
  • 3-Elcometrine

What is the function of anti-progestin?

<p>It competes with progesterone for its receptors and prevents binding (A)</p> Signup and view all the answers

What is a characteristic of Mifepristone (Mifeprex)?

<p>It has both antiprogestin and antiglucocorticoid activity (D)</p> Signup and view all the answers

What is the primary difference between Mifepristone and Onapristone?

<p>Onapristone has less antiglucocorticoid activity (C)</p> Signup and view all the answers

Which progestin has a C21 hydroxyl group?

<p>5-Trimegestrone (A)</p> Signup and view all the answers

What is the advantage of 4-Nomogestrol over megestrol acetate?

<p>It has better selectivity to the progesterone receptor (D)</p> Signup and view all the answers

What is a possible therapeutic use of Mifepristone and Onapristone?

<p>Breast cancer therapy (D)</p> Signup and view all the answers

What is the structural difference between 2-Dienogest and norethindrone?

<p>2-Dienogest has a cyanomethyl group (A)</p> Signup and view all the answers

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