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Pharmacotherapy: Steroids and Sex Hormones

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Pharmacotherapy: Steroids and Sex Hormones

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Questions and Answers

What is a distinct feature of the 2-Dienogest progestin?

Has a C17 ethynyl group
Has a cyanomethyl group (correct)
Has a C21 hydroxyl group
Lacks the angular C19 methyl group

What is the effect of administrating 3-Elcometrine via subcutaneous (SC) versus oral route?

It is 100 times less potent when administered SC
It has the same potency when administered via both routes
It is 100 times more potent when administered SC (correct)
It is not absorbed when administered orally

Which progestin is similar to megestrol acetate but has better selectivity to the progesterone receptor?

2-Dienogest
4-Nomogestrol (correct)
5-Trimegestrone
3-Elcometrine

What is the function of anti-progestin?

It competes with progesterone for its receptors and prevents binding (A) Signup and view all the answers

What is a characteristic of Mifepristone (Mifeprex)?

It has both antiprogestin and antiglucocorticoid activity (D) Signup and view all the answers

What is the primary difference between Mifepristone and Onapristone?

Onapristone has less antiglucocorticoid activity (C) Signup and view all the answers

Which progestin has a C21 hydroxyl group?

5-Trimegestrone (A) Signup and view all the answers

What is the advantage of 4-Nomogestrol over megestrol acetate?

It has better selectivity to the progesterone receptor (D) Signup and view all the answers

What is a possible therapeutic use of Mifepristone and Onapristone?

Breast cancer therapy (D) Signup and view all the answers

What is the structural difference between 2-Dienogest and norethindrone?

2-Dienogest has a cyanomethyl group (A) Signup and view all the answers