Pharmacology: Parecoxib (Dynastat) and NSAIDs Quiz

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Questions and Answers

What effect does low-dose ASA have before surgery?

  • Antipyretic effect
  • Antiplatelet effect (correct)
  • Anticoagulant effect
  • Antibiotic effect

What condition can NSAIDs help suppress?

  • Familial intestinal polyposis (correct)
  • Rheumatoid arthritis
  • Colon cancer
  • Alzheimer’s disease

Where are most NSAIDs well absorbed from?

  • Skin
  • GI tract (correct)
  • Rectum
  • Lungs

What percentage of NSAIDs are highly plasma protein-bound?

<p>99% (A)</p> Signup and view all the answers

After repeated dosing, where are NSAIDs found in the body?

<p>Synovial fluid (C)</p> Signup and view all the answers

What is the main reason for using Meloxicam in postoperative pain?

<p>To provide long-lasting pain relief (B)</p> Signup and view all the answers

Which adverse effect may be encountered with high loading doses of Meloxicam?

<p>Gastrointestinal bleeding (D)</p> Signup and view all the answers

What is a clinical consideration for rational therapy selection with Meloxicam?

<p>Considering individual patient-related factors (A)</p> Signup and view all the answers

Why is it recommended to use low doses of Meloxicam to achieve the maximum therapeutic effect?

<p>To minimize gastrointestinal bleeding risk (D)</p> Signup and view all the answers

What distinguishes Meloxicam from traditional NSAIDs in its use for postoperative pain?

<p>Longer duration of action and loading doses (C)</p> Signup and view all the answers

What is the mechanism of action of Acetylsalicylate (Aspirin)?

<p>Inhibits COX-1 and COX-2 irreversibly (A)</p> Signup and view all the answers

Which enzyme does Parecoxib inhibit?

<p>COX-2 (B)</p> Signup and view all the answers

Which type of pain is Meloxicam particularly effective at managing?

<p>Acute inflammatory pain (D)</p> Signup and view all the answers

Why is Acetylsalicylate rarely used for antipyretic analgesic and anti-inflammatory purposes nowadays?

<p>It has a reversible inhibition of COX enzymes (B)</p> Signup and view all the answers

Which NSAID is mentioned to have both direct and indirect effects?

<p>Parecoxib (D)</p> Signup and view all the answers

What is the primary therapeutic effect of Salicylic acid derivatives?

<p>Anti-inflammatory effect (A)</p> Signup and view all the answers

Which enzyme does Aspirin act upon to exert its antipyretic effect?

<p>IL-1 (A)</p> Signup and view all the answers

What is the renal-sparing effect associated with indomethacin?

<p>Moderate dose renal protection (D)</p> Signup and view all the answers

Which adverse effect is NOT commonly associated with indomethacin use?

<p>Thrombocytopenia (C)</p> Signup and view all the answers

What is the preferential target of Etodolac (Etonox®) compared to Indomethacin?

<p>COX-2 (D)</p> Signup and view all the answers

What is a characteristic of Diclofenac's metabolism that distinguishes it from other drugs mentioned?

<p>Low first pass metabolism (A)</p> Signup and view all the answers

Which condition is NOT an adverse effect associated with Indomethacin?

<p>Renal-sparing effect (C)</p> Signup and view all the answers

Which drug shows a renal-sparing effect at moderate doses?

<p>Indomethacin (D)</p> Signup and view all the answers

What is the therapeutic use of peroxide?

<p>Analgesic &amp; antipyretic (C)</p> Signup and view all the answers

Which of the following does peroxide NOT affect?

<p>Blood glucose levels (B)</p> Signup and view all the answers

What is the maximum daily dosage of paracetamol for adults?

<p>4 g (C)</p> Signup and view all the answers

In children, how many doses of paracetamol can be given in 24 hours?

<p>&gt;5 doses (B)</p> Signup and view all the answers

What is a characteristic of paracetamol regarding plasma-protein binding?

<p>Low plasma-protein binding (A)</p> Signup and view all the answers

Where is peroxide distributed in the body?

<p>Widely distributed to peripheral &amp; CNS (D)</p> Signup and view all the answers

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