Pharmacology: Parecoxib (Dynastat) and NSAIDs Quiz

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What effect does low-dose ASA have before surgery?

Antipyretic effect

Antiplatelet effect (correct)

Anticoagulant effect

Antibiotic effect

What condition can NSAIDs help suppress?

Familial intestinal polyposis (correct)

Rheumatoid arthritis

Colon cancer

Alzheimer’s disease

Where are most NSAIDs well absorbed from?

Skin

GI tract (correct)

Rectum

Lungs

What percentage of NSAIDs are highly plasma protein-bound?

99% Signup and view all the answers

After repeated dosing, where are NSAIDs found in the body?

Synovial fluid Signup and view all the answers

What is the main reason for using Meloxicam in postoperative pain?

To provide long-lasting pain relief Signup and view all the answers

Which adverse effect may be encountered with high loading doses of Meloxicam?

Gastrointestinal bleeding Signup and view all the answers

What is a clinical consideration for rational therapy selection with Meloxicam?

Considering individual patient-related factors Signup and view all the answers

Why is it recommended to use low doses of Meloxicam to achieve the maximum therapeutic effect?

To minimize gastrointestinal bleeding risk Signup and view all the answers

What distinguishes Meloxicam from traditional NSAIDs in its use for postoperative pain?

Longer duration of action and loading doses Signup and view all the answers

What is the mechanism of action of Acetylsalicylate (Aspirin)?

Inhibits COX-1 and COX-2 irreversibly Signup and view all the answers

Which enzyme does Parecoxib inhibit?

COX-2 Signup and view all the answers

Which type of pain is Meloxicam particularly effective at managing?

Acute inflammatory pain Signup and view all the answers

Why is Acetylsalicylate rarely used for antipyretic analgesic and anti-inflammatory purposes nowadays?

It has a reversible inhibition of COX enzymes Signup and view all the answers

Which NSAID is mentioned to have both direct and indirect effects?

Parecoxib Signup and view all the answers

What is the primary therapeutic effect of Salicylic acid derivatives?

Anti-inflammatory effect Signup and view all the answers

Which enzyme does Aspirin act upon to exert its antipyretic effect?

IL-1 Signup and view all the answers

What is the renal-sparing effect associated with indomethacin?

Moderate dose renal protection Signup and view all the answers

Which adverse effect is NOT commonly associated with indomethacin use?

Thrombocytopenia Signup and view all the answers

What is the preferential target of Etodolac (Etonox®) compared to Indomethacin?

COX-2 Signup and view all the answers

What is a characteristic of Diclofenac's metabolism that distinguishes it from other drugs mentioned?

Low first pass metabolism Signup and view all the answers

Which condition is NOT an adverse effect associated with Indomethacin?

Renal-sparing effect Signup and view all the answers

Which drug shows a renal-sparing effect at moderate doses?

Indomethacin Signup and view all the answers

What is the therapeutic use of peroxide?

Analgesic & antipyretic Signup and view all the answers

Which of the following does peroxide NOT affect?

Blood glucose levels Signup and view all the answers

What is the maximum daily dosage of paracetamol for adults?

4 g Signup and view all the answers

In children, how many doses of paracetamol can be given in 24 hours?

>5 doses Signup and view all the answers

What is a characteristic of paracetamol regarding plasma-protein binding?

Low plasma-protein binding Signup and view all the answers

Where is peroxide distributed in the body?

Widely distributed to peripheral & CNS Signup and view all the answers