Podcast
Questions and Answers
What is the brand name for Methyl Salicylate?
What is the brand name for Methyl Salicylate?
- Feldene
- Salonpas (correct)
- Brufen
- Pepto Bismol
Which medication is classified as a Phenylbutazone derivative?
Which medication is classified as a Phenylbutazone derivative?
- Voltaren
- Celebrex
- Butazolidin (correct)
- Lodine SR
What is the generic name for Pepto Bismol?
What is the generic name for Pepto Bismol?
- Naproxen
- Indomethacin
- Bismuth Subsalicylate (correct)
- Methyl Salicylate
Which drug is a Selective COX-2 Inhibitor?
Which drug is a Selective COX-2 Inhibitor?
What is the brand name for Paracetamol?
What is the brand name for Paracetamol?
Which medication was withdrawn due to safety concerns?
Which medication was withdrawn due to safety concerns?
What is the primary reason why NSAIDs are contraindicated for people with hypertension?
What is the primary reason why NSAIDs are contraindicated for people with hypertension?
What is a common risk factor that contributes to NSAID-induced gastrointestinal ulceration?
What is a common risk factor that contributes to NSAID-induced gastrointestinal ulceration?
Which NSAID has a long-half life of 50 hours and a higher risk for peptic ulcer disease?
Which NSAID has a long-half life of 50 hours and a higher risk for peptic ulcer disease?
Why are aspirin and tolmetin contraindicated in individuals with gout?
Why are aspirin and tolmetin contraindicated in individuals with gout?
What is the mechanism of action of opioids?
What is the mechanism of action of opioids?
Which NSAID category includes Bismuth subsalicylate, which is used for peptic ulcer disease?
Which NSAID category includes Bismuth subsalicylate, which is used for peptic ulcer disease?
Which NSAID was withdrawn from the market due to bone marrow suppression and Steven-Johnson syndrome?
Which NSAID was withdrawn from the market due to bone marrow suppression and Steven-Johnson syndrome?
What is the primary effect of NSAIDs on vasodilation during inflammatory processes?
What is the primary effect of NSAIDs on vasodilation during inflammatory processes?
Which category of NSAID includes Paracetamol (Tylenol) as a weak anti-inflammatory agent?
Which category of NSAID includes Paracetamol (Tylenol) as a weak anti-inflammatory agent?
What is the primary mechanism through which NSAIDs induce gastrointestinal ulceration?
What is the primary mechanism through which NSAIDs induce gastrointestinal ulceration?
Which NSAID has the advantage of lesser risk for NSAID-induced peptic ulcer disease but a disadvantage of acute thrombotic events like stroke and myocardial infarction?
Which NSAID has the advantage of lesser risk for NSAID-induced peptic ulcer disease but a disadvantage of acute thrombotic events like stroke and myocardial infarction?
What is the major pathway of metabolism for Paracetamol (Tylenol)?
What is the major pathway of metabolism for Paracetamol (Tylenol)?
Flashcards
Methyl Salicylate brand name
Methyl Salicylate brand name
The brand name for Methyl Salicylate is Salonpas.
Phenylbutazone derivative
Phenylbutazone derivative
Butazolidin is a medication classified as a Phenylbutazone derivative.
Pepto-Bismol generic name
Pepto-Bismol generic name
The generic name for Pepto-Bismol is Bismuth Subsalicylate.
Selective COX-2 Inhibitor example
Selective COX-2 Inhibitor example
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Paracetamol Brand Name
Paracetamol Brand Name
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Valdecoxib withdrawal
Valdecoxib withdrawal
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NSAID hypertension link
NSAID hypertension link
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NSAID-induced ulcers risk factor
NSAID-induced ulcers risk factor
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Piroxicam half-life
Piroxicam half-life
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Aspirin/Tolmetin and Gout
Aspirin/Tolmetin and Gout
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Opioid mechanism of action
Opioid mechanism of action
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Salicylate NSAID category example
Salicylate NSAID category example
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Rofecoxib withdrawal reason
Rofecoxib withdrawal reason
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NSAID effect on vasodilation
NSAID effect on vasodilation
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Paracetamol NSAID category
Paracetamol NSAID category
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NSAID gastrointestinal ulceration mechanism
NSAID gastrointestinal ulceration mechanism
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Celecoxib advantage/disadvantage
Celecoxib advantage/disadvantage
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Paracetamol metabolism pathway
Paracetamol metabolism pathway
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Study Notes
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
- A sharp decline in fever within 24 hours directs the workup away from infection and suggests a neoplastic disorder
- Tolmetin (Tolectin ®) is contraindicated in patients with gout
- Pyrazolone derivatives include phenylbutazone (Butazolidine ®) and oxiphenbutazone
Categories of NSAIDs
- Non-Selective COX Inhibitors:
- Salicylates: methyl salicylate (Salonpas ®), bismuth subsalicylate (Pepto-bismol ®)
- Indole derivatives: indomethacin (Indocin ®)
- Oxicam derivatives: piroxicam (Feldene ®)
- Phenylacetic acid derivatives: diclofenac (Voltaren ®)
- Pyrolealkanoic acid derivatives: tolmetin (Tolectin ®)
- Selective COX-2 Inhibitors:
- Oxicam derivatives: meloxicam (Mobic ®)
- Phenylacetic acid derivatives: etodolac (Lodine ®)
- Coxibs: celecoxib (Celebrex ®), etoricoxib (Arcoxia ®)
Mechanism of Action of NSAIDs
- Inhibit COX, leading to decreased PGE production
- Non-selective COX inhibitors inhibit both COX-1 and COX-2
- Selective COX-2 inhibitors inhibit only COX-2
Side Effects and Adverse Effects of NSAIDs
- Gastrointestinal ulceration (inhibition of COX-1, PGE production)
- Sodium and water retention (inhibition of PG-induced inhibition of renal chloride reabsorption)
- Reversible inhibition of GFR
- Nephrotoxic effects
- Hypersensitivity reactions (asthma-induced allergy)
Paracetamol (Acetaminophen)
- Has analgesic and antipyretic activity, but weak anti-inflammatory activity
- Mechanism of action: weak peripheral inhibitor of COX at peripheral circulation
- Metabolism: major pathway is sulfation and glucuronidation; minor pathway is GSH conjugation
- Toxic metabolite: N-acetyl para-benzoquinone imine
- Non-toxic metabolite: mercapturic acid
- Maximum dose: 4000mg or 8 tablets
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Description
Test your knowledge on NSAIDs with questions about their indications, contraindications, and adverse effects. Learn about specific NSAIDs such as Tolmetin, Phenybutazone, and Piroxicam.
