Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
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Questions and Answers

What is the core purpose of Serotonin-Norepinephrine Inhibitors (SNRIs)?

Decrease neuronal reuptake of both serotonin and norepinephrine.

Which of the following medications is an SNRI?

  • Venlafaxine
  • Duloxetine (Cymbalta)
  • Both A and B (correct)
  • Neither A nor B

Which of the following is an indication for prescribing an SNRI?

  • Anxiety
  • Fibromyalgia
  • PMDD
  • All of the above (correct)

Which of the following is a contraindication for prescribing an SNRI?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is a potential adverse effect of SNRI medications?

<p>All of the above (D)</p> Signup and view all the answers

Which medications have drug-drug interactions with SNRIs?

<p>Both A and B (C)</p> Signup and view all the answers

What is the typical onset effectiveness timeframe for SNRIs?

<p>6-8 weeks</p> Signup and view all the answers

SNRIs increase the reuptake of serotonin and norepinephrine.

<p>False (B)</p> Signup and view all the answers

Flashcards

SNRI Core Purpose

Reduce reuptake of serotonin and norepinephrine in neurons.

SNRI Example 1

Duloxetine.

SNRI Example 2

Venlafaxine.

SNRI Indications

Major depressive disorder, anxiety, fibromyalgia, PMDD, diabetic neuropathy.

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SNRI Contraindications

Severe depression, suicidality, bipolar disorder, pregnancy/breastfeeding.

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SNRI Adverse Effects

Anxiety, agitation, sexual dysfunction, insomnia, GI upset, weight changes, serotonin syndrome.

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SNRI Drug-Drug Interactions

Other anti-depressants and anticoagulants.

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SNRI Onset of Effectiveness

6-8 weeks.

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Serotonin Syndrome

Serotonin syndrome is a potentially life-threatening condition that can occur with the use of serotonergic medications.

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PMDD meaning

PMDD.

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Study Notes

  • Serotonin-Norepinephrine Inhibitors (SNRIs) decrease neuronal reuptake of both serotonin and norepinephrine

Names

  • Duloxetine (Cymbalta)
  • Venlafaxine

Indications

  • Major depressive disorder
  • Anxiety
  • Fibromyalgia
  • PMDD
  • Diabetic neuropathy

Adverse Effects

  • Anxiety
  • Agitation
  • Restlessness
  • Sexual Dysfunction
  • Insomnia
  • Nightmares
  • Drowsiness
  • Apathy
  • GI upset
  • Weight gain or loss
  • Serotonin syndrome

Contraindications

  • Severe Depression
  • Suicidality
  • Bipolar disorder
  • Pregnancy
  • Breastfeeding

Drug-Drug

  • Other anti-depressants
  • Anticoagulants

Onset Effectiveness

  • 6-8 weeks

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Description

Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) decrease neuronal reuptake of both serotonin and norepinephrine. Common examples are duloxetine and venlafaxine. They are typically prescribed for major depressive disorder, anxiety, fibromyalgia, PMDD, and diabetic neuropathy.

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