Pharmacology of Norfentanyl and Hydroxyproprionyl-Fentanyl

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Questions and Answers

What is a unique effect of morphine on the cardiovascular system?

  • Rapidly increasing mean arterial pressure
  • Inducing bradycardia (correct)
  • Enhancing venous tone
  • Increasing systemic vascular resistance

How can opioids like morphine affect respiratory function?

  • Exacerbating respiratory depression in alkalotic states (correct)
  • Increasing minute ventilation
  • Decreasing end-tidal CO2 levels
  • Improving renal function

Which opioid has roughly 1/10th the potency of morphine and produces the active metabolite normeperidine?

  • Meperidine (correct)
  • Morphine
  • Fentanyl
  • Remifentanil

What is a unique property of fentanyl compared to morphine?

<p>Higher potency and large volume of distribution (A)</p> Signup and view all the answers

How do opioids generally affect the gastrointestinal tract?

<p>Sphincter of Oddi spasm (B)</p> Signup and view all the answers

What is a potential risk associated with the active metabolite of meperidine?

<p>Neuroexcitatory properties (A)</p> Signup and view all the answers

Which opioid is commonly used for MONA therapy for chest pain but can result in cardiovascular depression when combined with benzodiazepines?

<p>'Morphine' (C)</p> Signup and view all the answers

Which phenomenon occurs due to the synergism between fentanyl and diazepam?

<p>Compensatory increase in heart rate (D)</p> Signup and view all the answers

What is the main reason for combining opioids with volatile anesthetics?

<p>To enhance myocardial protection (D)</p> Signup and view all the answers

Which opioid is known for being fast-acting with a short half-life, making it suitable for rapid analgesia and postoperative pain control?

<p>Remifentanil (D)</p> Signup and view all the answers

What is the main concern associated with the use of naloxone and naltrexone?

<p>Renarcotization (B)</p> Signup and view all the answers

Which opioid is particularly effective for anxiolysis, postoperative intermittent bolus doses, and labor?

<p>Fentanyl (D)</p> Signup and view all the answers

Which opioid is 5-10 times more potent than fentanyl and has a high degree of protein binding?

<p>Sufentanil (B)</p> Signup and view all the answers

What feature makes alfentanil unique compared to fentanyl and other opioids?

<p>Rapid equilibration to inactive tissues (B)</p> Signup and view all the answers

Which opioid is 10 times more potent than morphine but has an increased risk of nausea, vomiting, and physical dependence?

<p>Oxymorphone (B)</p> Signup and view all the answers

In comparison to other opioids, what distinguishes hydromorphone as a preferred choice for PCA and intrathecal administration?

<p>5 times more potent than morphine (D)</p> Signup and view all the answers

How does remifentanil affect the hemodynamic response during anesthesia in comparison to volatile anesthetics?

<p>Blunts the hemodynamic response and reduces the MAC of volatile anesthetics (B)</p> Signup and view all the answers

What feature makes norfentanyl and hydroxyproprionyl-fentanyl unsuitable for outpatient surgeries?

<p>Prolonged elimination half-time despite minimal pharmacologic activity (D)</p> Signup and view all the answers

What characteristic of opioids like pentazocine, butorphanol, nalbuphine, and buprenorphine differentiates them from pure opioid agonists?

<p>Offering analgesia with less depression of ventilation (C)</p> Signup and view all the answers

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