19 Questions
What is a unique effect of morphine on the cardiovascular system?
Inducing bradycardia
How can opioids like morphine affect respiratory function?
Exacerbating respiratory depression in alkalotic states
Which opioid has roughly 1/10th the potency of morphine and produces the active metabolite normeperidine?
Meperidine
What is a unique property of fentanyl compared to morphine?
Higher potency and large volume of distribution
How do opioids generally affect the gastrointestinal tract?
Sphincter of Oddi spasm
What is a potential risk associated with the active metabolite of meperidine?
Neuroexcitatory properties
Which opioid is commonly used for MONA therapy for chest pain but can result in cardiovascular depression when combined with benzodiazepines?
'Morphine'
Which phenomenon occurs due to the synergism between fentanyl and diazepam?
Compensatory increase in heart rate
What is the main reason for combining opioids with volatile anesthetics?
To enhance myocardial protection
Which opioid is known for being fast-acting with a short half-life, making it suitable for rapid analgesia and postoperative pain control?
Remifentanil
What is the main concern associated with the use of naloxone and naltrexone?
Renarcotization
Which opioid is particularly effective for anxiolysis, postoperative intermittent bolus doses, and labor?
Fentanyl
Which opioid is 5-10 times more potent than fentanyl and has a high degree of protein binding?
Sufentanil
What feature makes alfentanil unique compared to fentanyl and other opioids?
Rapid equilibration to inactive tissues
Which opioid is 10 times more potent than morphine but has an increased risk of nausea, vomiting, and physical dependence?
Oxymorphone
In comparison to other opioids, what distinguishes hydromorphone as a preferred choice for PCA and intrathecal administration?
5 times more potent than morphine
How does remifentanil affect the hemodynamic response during anesthesia in comparison to volatile anesthetics?
Blunts the hemodynamic response and reduces the MAC of volatile anesthetics
What feature makes norfentanyl and hydroxyproprionyl-fentanyl unsuitable for outpatient surgeries?
Prolonged elimination half-time despite minimal pharmacologic activity
What characteristic of opioids like pentazocine, butorphanol, nalbuphine, and buprenorphine differentiates them from pure opioid agonists?
Offering analgesia with less depression of ventilation
Test your knowledge on the pharmacologic properties of norfentanyl, hydroxyproprionyl-fentanyl, and their derivatives. Explore concepts such as elimination half-time, protein binding, and redistribution to tissues.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
