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Pharmacology of Local Anaesthesia (BDS & DTH Year 1)

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10 Questions

Which type of nerve fibers are most affected by local anaesthetics?

Smaller neuronal alpha-delta fibres

What is the elimination half-life of lignocaine in the liver?

2 hours

What is the primary mechanism of cardiovascular toxicity caused by lignocaine?

Blockage of sodium channels

What is the primary cause of true allergy to local anaesthetics?

Type I IgE-mediated immunological reaction

What is the common symptom of an allergic reaction to ester-type local anaesthetics?

Generalised urticaria and pruritus

What is the reason for avoiding octapressin in pregnancy?

It can induce labour

What is the common cause of autonomic response to an injection in patients undergoing dental procedures?

Anxiety or adrenaline injection

What is the first modality to disappear during local anaesthesia?

Pain

What is the primary factor that determines the plasma concentration of local anaesthetics?

All of the above

What is the common complication of local anaesthesia at therapeutic plasma concentrations?

Tachycardia

This quiz covers the pharmacology of local anaesthesia, including pain management, action potential and pain pathways, chemical composition, and mechanisms of action of local anaesthetics.

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