Pharmacology of Local Anaesthesia (BDS & DTH Year 1)
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Questions and Answers

Which type of nerve fibers are most affected by local anaesthetics?

  • Neurons positioned deeper within the tissue
  • Larger neurons with more myelin
  • Neurons with less myelin
  • Smaller neuronal alpha-delta fibres (correct)
  • What is the elimination half-life of lignocaine in the liver?

  • 3 hours
  • 1 hour
  • 2 hours (correct)
  • 4 hours
  • What is the primary mechanism of cardiovascular toxicity caused by lignocaine?

  • Blockage of chloride channels
  • Blockage of calcium channels
  • Blockage of potassium channels
  • Blockage of sodium channels (correct)
  • What is the primary cause of true allergy to local anaesthetics?

    <p>Type I IgE-mediated immunological reaction</p> Signup and view all the answers

    What is the common symptom of an allergic reaction to ester-type local anaesthetics?

    <p>Generalised urticaria and pruritus</p> Signup and view all the answers

    What is the reason for avoiding octapressin in pregnancy?

    <p>It can induce labour</p> Signup and view all the answers

    What is the common cause of autonomic response to an injection in patients undergoing dental procedures?

    <p>Anxiety or adrenaline injection</p> Signup and view all the answers

    What is the first modality to disappear during local anaesthesia?

    <p>Pain</p> Signup and view all the answers

    What is the primary factor that determines the plasma concentration of local anaesthetics?

    <p>All of the above</p> Signup and view all the answers

    What is the common complication of local anaesthesia at therapeutic plasma concentrations?

    <p>Tachycardia</p> Signup and view all the answers

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