Pharmacology of Epinephrine, Norepinephrine & Dobutamine
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Questions and Answers

Which of the following is the most common indication for the use of epinephrine (adrenaline)?

  • Increasing blood pressure in shock
  • Treating asthma
  • Treating anaphylaxis (correct)
  • Increasing inotropy in bradycardia

    • What is the primary mechanism of action of dobutamine?

  • Inhibitor of monoamine oxidase (MAO)
  • Selective beta-1 adrenergic agonist (correct)
  • Selective alpha-1 adrenergic agonist
  • Nonselective alpha and beta adrenergic agonist

    • What is the primary route of administration for dobutamine?

  • Intravenous (correct)
  • Transdermal
  • Oral
  • Intramuscular

    • What is the primary metabolic pathway for dipivefrin?

    <p>Hydrolysis to epinephrine</p> Signup and view all the answers

    Which of the following is a contraindication for the use of dobutamine?

    <p>Hypovolemia</p> Signup and view all the answers

    Which of the following is a common adverse effect of epinephrine (adrenaline) administration?

    <p>Central nervous system stimulation</p> Signup and view all the answers

    What is the primary mechanism of action of dipivefrin?

    <p>Prodrug hydrolyzed to epinephrine</p> Signup and view all the answers

    What is the therapeutic class of the drug Pitolisant?

    <p>Narcolepsy Agent</p> Signup and view all the answers

    Which enzyme system is involved in the metabolism of Pitolisant?

    <p>CYP2D6 and CYP3A4</p> Signup and view all the answers

    What is the primary mechanism of action of Pitolisant?

    <p>Histamine H3 receptor antagonism and inverse agonism</p> Signup and view all the answers

    Which of the following is a contraindication for the use of Pitolisant?

    <p>Liver disease</p> Signup and view all the answers

    What is the mechanism of action of H2 histamine receptor antagonists like Famotidine and Cimetidine?

    <p>Inhibition of gastric acid production by blocking the H2 histamine receptors</p> Signup and view all the answers

    Which of the following is a common adverse effect associated with the use of H2 histamine receptor antagonists?

    <p>Atrophic gastritis</p> Signup and view all the answers

    Which of the following drug interactions is observed with H2 histamine receptor antagonists?

    <p>Decreased effectiveness of proton pump inhibitors</p> Signup and view all the answers

    What is the primary pharmacological action of topical alpha2 agonists?

    <p>Reduce intraocular pressure</p> Signup and view all the answers

    Which drug class promotes smooth muscle relaxation by blocking the actions of norepinephrine?

    <p>Nonselective Alpha1 Blockers</p> Signup and view all the answers

    What is the main indication for using brimonidine?

    <p>Glaucoma</p> Signup and view all the answers

    Which adverse effect is associated with systemic alpha2 agonists?

    <p>CV depression</p> Signup and view all the answers

    What is a notable drug interaction associated with systemic alpha2 agonists?

    <p>Interaction with any drug that binds adrenergic receptors</p> Signup and view all the answers

    Which type of alpha1 blockers bind to Alpha1A/1B/1D receptors and are known as 'Zosins'?

    <p>Nonselective Alpha1 Blockers</p> Signup and view all the answers

    What is the main pharmacological action of systemic alpha 2 agonists?

    <p>Reduce sympathetic outflow</p> Signup and view all the answers

    What is the primary mechanism of action of sucralfate?

    <p>Forms a protective barrier on the damaged gastric mucosa</p> Signup and view all the answers

    Which of the following is a contraindication for the use of sucralfate?

    <p>Respiratory disorders</p> Signup and view all the answers

    What is the potential drug interaction between sucralfate and antacids?

    <p>Antacids decrease the effectiveness of sucralfate</p> Signup and view all the answers

    Which of the following is an example of a prokinetic agent?

    <p>Lubiprostone</p> Signup and view all the answers

    What is the primary clinical use of prokinetic agents?

    <p>GI motility disorders, especially severe constipation</p> Signup and view all the answers

    What is the mechanism of action of lubiprostone?

    <p>Activates chloride ion channels</p> Signup and view all the answers

    Which of the following is a potential adverse effect associated with the use of sucralfate?

    <p>Respiratory complications</p> Signup and view all the answers

    What is the primary clinical use of sucralfate?

    <p>Treatment of duodenal (not peptic) ulcers</p> Signup and view all the answers

    What is the mechanism of action of proton pump inhibitors?

    <p>Inhibit actively secreting H+/K+ -ATPase</p> Signup and view all the answers

    Which proton pump inhibitor is NOT primarily metabolized through a pH-dependent mechanism?

    <p>Esomeprazole</p> Signup and view all the answers

    What is the clinical use of Misoprostol?

    <p>NSAID-induced ulcer prophylaxis</p> Signup and view all the answers

    Which drug class poses an increased risk for vitamin B12 deficiency if used for more than 2 years?

    <p>Proton pump inhibitors</p> Signup and view all the answers

    What adverse effect is associated with Misoprostol due to its oxytocic properties?

    <p>Abdominal cramps</p> Signup and view all the answers

    'CYP3A4 substrates' refers to which of the following proton pump inhibitors?

    <p>Rabeprazole</p> Signup and view all the answers

    'Osteoporosis' is listed as a contraindication for which class of drugs?

    <p>Proton pump inhibitors</p> Signup and view all the answers

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