Pharmacology of Epinephrine, Norepinephrine & Dobutamine

Play an AI-generated podcast conversation about this lesson

Which of the following is the most common indication for the use of epinephrine (adrenaline)?

Increasing blood pressure in shock

Treating asthma

Treating anaphylaxis (correct)

Increasing inotropy in bradycardia

What is the primary mechanism of action of dobutamine?

Inhibitor of monoamine oxidase (MAO)

Selective beta-1 adrenergic agonist (correct)

Selective alpha-1 adrenergic agonist

Nonselective alpha and beta adrenergic agonist

What is the primary route of administration for dobutamine?

Intravenous (correct)

Transdermal

Oral

Intramuscular

What is the primary metabolic pathway for dipivefrin?

Hydrolysis to epinephrine Signup and view all the answers

Which of the following is a contraindication for the use of dobutamine?

Hypovolemia Signup and view all the answers

Which of the following is a common adverse effect of epinephrine (adrenaline) administration?

Central nervous system stimulation Signup and view all the answers

What is the primary mechanism of action of dipivefrin?

Prodrug hydrolyzed to epinephrine Signup and view all the answers

What is the therapeutic class of the drug Pitolisant?

Narcolepsy Agent Signup and view all the answers

Which enzyme system is involved in the metabolism of Pitolisant?

CYP2D6 and CYP3A4 Signup and view all the answers

What is the primary mechanism of action of Pitolisant?

Histamine H3 receptor antagonism and inverse agonism Signup and view all the answers

Which of the following is a contraindication for the use of Pitolisant?

Liver disease Signup and view all the answers

What is the mechanism of action of H2 histamine receptor antagonists like Famotidine and Cimetidine?

Inhibition of gastric acid production by blocking the H2 histamine receptors Signup and view all the answers

Which of the following is a common adverse effect associated with the use of H2 histamine receptor antagonists?

Atrophic gastritis Signup and view all the answers

Which of the following drug interactions is observed with H2 histamine receptor antagonists?

Decreased effectiveness of proton pump inhibitors Signup and view all the answers

What is the primary pharmacological action of topical alpha2 agonists?

Reduce intraocular pressure Signup and view all the answers

Which drug class promotes smooth muscle relaxation by blocking the actions of norepinephrine?

Nonselective Alpha1 Blockers Signup and view all the answers

What is the main indication for using brimonidine?

Glaucoma Signup and view all the answers

Which adverse effect is associated with systemic alpha2 agonists?

CV depression Signup and view all the answers

What is a notable drug interaction associated with systemic alpha2 agonists?

Interaction with any drug that binds adrenergic receptors Signup and view all the answers

Which type of alpha1 blockers bind to Alpha1A/1B/1D receptors and are known as 'Zosins'?

Nonselective Alpha1 Blockers Signup and view all the answers

What is the main pharmacological action of systemic alpha 2 agonists?

Reduce sympathetic outflow Signup and view all the answers

What is the primary mechanism of action of sucralfate?

Forms a protective barrier on the damaged gastric mucosa Signup and view all the answers

Which of the following is a contraindication for the use of sucralfate?

Respiratory disorders Signup and view all the answers

What is the potential drug interaction between sucralfate and antacids?

Antacids decrease the effectiveness of sucralfate Signup and view all the answers

Which of the following is an example of a prokinetic agent?

Lubiprostone Signup and view all the answers

What is the primary clinical use of prokinetic agents?

GI motility disorders, especially severe constipation Signup and view all the answers

What is the mechanism of action of lubiprostone?

Activates chloride ion channels Signup and view all the answers

Which of the following is a potential adverse effect associated with the use of sucralfate?

Respiratory complications Signup and view all the answers

What is the primary clinical use of sucralfate?

Treatment of duodenal (not peptic) ulcers Signup and view all the answers

What is the mechanism of action of proton pump inhibitors?

Inhibit actively secreting H+/K+ -ATPase Signup and view all the answers

Which proton pump inhibitor is NOT primarily metabolized through a pH-dependent mechanism?

Esomeprazole Signup and view all the answers

What is the clinical use of Misoprostol?

NSAID-induced ulcer prophylaxis Signup and view all the answers

Which drug class poses an increased risk for vitamin B12 deficiency if used for more than 2 years?

Proton pump inhibitors Signup and view all the answers