10 Questions
Which receptors do epinephrine and norepinephrine primarily target?
Nonselective α1,2 and β1,2 adrenoreceptors
What is the clinical use of phenylephrine?
Mydriatic effect
What side effect is associated with high doses of epinephrine?
Vasoconstriction and increased blood pressure
What side effect is associated with phenylephrine in acute hypotension?
Vasoconstriction and increased blood pressure
What is the mechanism of action of adrenopositive agents?
Nonselective α1,2 and β1,2 adrenoreceptor agonist
Which adrenoreceptor agonist primarily targets selective α1 receptors?
Phenylephrine
What is the clinical use of nonselective α1,2 and selective β1 adrenoreceptor agonists?
Cardiotonic effect
Which side effect is associated with high doses of epinephrine?
Vasoconstriction
What is the primary clinical use of adrenopositive agents in anaphylactic shock?
Vasoconstriction
Which adrenoreceptor agonist has a mydriatic effect?
Epinephrine
Study Notes
Adrenergic Receptors and Agonists
- Epinephrine and norepinephrine primarily target α and β receptors.
Phenylephrine
- Phenylephrine is used clinically to treat acute hypotension.
- High doses of phenylephrine can cause increased blood pressure, leading to headache and cardiac arrhythmias.
Epinephrine
- High doses of epinephrine can cause anxiety, tremors, and palpitations.
- Epinephrine is used clinically to treat anaphylactic shock.
Mechanism of Action
- Adrenopositive agents act by stimulating adrenergic receptors, increasing the activity of the sympathetic nervous system.
Selective Adrenergic Agonists
- Phenylephrine is a selective α1 receptor agonist.
- Nonselective α1,2 and selective β1 adrenoreceptor agonists are used clinically to treat hypotension and heart failure.
Adrenergic Agonists and Side Effects
- High doses of epinephrine can cause anxiety, tremors, and palpitations.
Mydriatic Effect
- Phenylephrine has a mydriatic effect, causing pupil dilation.
Test your knowledge on the pharmacology of adrenergic agents! This quiz covers the mechanism of action and classification of adrenopositive agents such as epinephrine, norepinephrine, and phenylephrine. Challenge yourself and see how well you understand the different adrenoreceptor agonists.
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