Podcast
Questions and Answers
What is the main advantage of aripiprazole as a partial agonist antipsychotic?
What is the main advantage of aripiprazole as a partial agonist antipsychotic?
No EPS even at 80% occupancy of D2 receptors
What are the common cardiovascular side effects of blocking a1-receptors?
What are the common cardiovascular side effects of blocking a1-receptors?
Orthostatic hypotension, drowsiness, and dizziness
What is the typical proportion by which receptor blockade is reduced for a partial agonist like aripiprazole?
What is the typical proportion by which receptor blockade is reduced for a partial agonist like aripiprazole?
Approximately 25%
What are the side effects associated with H1 histamine receptor blockade?
What are the side effects associated with H1 histamine receptor blockade?
Signup and view all the answers
What are some of the obesity-associated disorders that excessive weight gain induced by antipsychotic drugs can lead to?
What are some of the obesity-associated disorders that excessive weight gain induced by antipsychotic drugs can lead to?
Signup and view all the answers
What criteria characterize atypical antipsychotic drugs?
What criteria characterize atypical antipsychotic drugs?
Signup and view all the answers
Which antipsychotic drugs have severe effects on weight gain, with mean increases potentially exceeding 5kg?
Which antipsychotic drugs have severe effects on weight gain, with mean increases potentially exceeding 5kg?
Signup and view all the answers
What is the basis for the difference between atypical and typical antipsychotic agents?
What is the basis for the difference between atypical and typical antipsychotic agents?
Signup and view all the answers
Name a few antipsychotic drugs that have negligible effects on weight gain.
Name a few antipsychotic drugs that have negligible effects on weight gain.
Signup and view all the answers
How do atypical antipsychotics differ from classical antipsychotics in terms of binding to the D2 receptor?
How do atypical antipsychotics differ from classical antipsychotics in terms of binding to the D2 receptor?
Signup and view all the answers
What is the main difference in mechanism of action between conventional antipsychotic drugs and atypical antipsychotic drugs?
What is the main difference in mechanism of action between conventional antipsychotic drugs and atypical antipsychotic drugs?
Signup and view all the answers
What is the role of 5-HT1A receptor partial agonism in some antipsychotic drugs like ziprasidone and aripiprazole?
What is the role of 5-HT1A receptor partial agonism in some antipsychotic drugs like ziprasidone and aripiprazole?
Signup and view all the answers
What are the side effects of conventional antipsychotics due to D2 receptor blockade in the nigrostriatal pathway?
What are the side effects of conventional antipsychotics due to D2 receptor blockade in the nigrostriatal pathway?
Signup and view all the answers
What condition is produced by an increase in prolactin levels due to dopamine receptor blockade in the tuberoinfundibular pathway?
What condition is produced by an increase in prolactin levels due to dopamine receptor blockade in the tuberoinfundibular pathway?
Signup and view all the answers
What is the syndrome of abnormal, involuntary, repetitive movements that may result from continued use of conventional antipsychotics?
What is the syndrome of abnormal, involuntary, repetitive movements that may result from continued use of conventional antipsychotics?
Signup and view all the answers
What pathway is responsible for the worsening of negative symptoms and potential cognitive dysfunction due to D2 receptor blockade by conventional antipsychotics?
What pathway is responsible for the worsening of negative symptoms and potential cognitive dysfunction due to D2 receptor blockade by conventional antipsychotics?
Signup and view all the answers
What are the side effects not related to D2 receptor blockade caused by the blockade of muscarinic receptors by antipsychotics?
What are the side effects not related to D2 receptor blockade caused by the blockade of muscarinic receptors by antipsychotics?
Signup and view all the answers
What is the condition characterized by restlessness and often alleviated by antimuscarinic drugs due to D2 receptor blockade in the nigrostriatal pathway?
What is the condition characterized by restlessness and often alleviated by antimuscarinic drugs due to D2 receptor blockade in the nigrostriatal pathway?
Signup and view all the answers
