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Pharmacology: NS5B Polymerase Inhibitors

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Pharmacology: NS5B Polymerase Inhibitors

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Questions and Answers

What is the function of Sofosbuvir in inhibiting HCV?

It activates the HCV NS5B RNA-dependent RNA polymerase

It inhibits the HCV NS5B RNA-dependent RNA polymerase (correct)

It eliminates the HCV from the urine

It inhibits the host cell kinases

What is Sofosbuvir classified as?

Nucleotide analog (correct)

NS5A inhibitor

Protease inhibitor

HCV NS3/4A inhibitor

How is Sofosbuvir activated?

By HCV RNA-dependent RNA polymerase

By ribavirin

By host cell kinases (correct)

By peginterferon alfa

What is the route of elimination of Sofosbuvir?

<p>Urine</p> Signup and view all the answers

What is the recommended combination therapy for Sofosbuvir?

<p>With peginterferon alfa and ribavirin</p> Signup and view all the answers

Study Notes

NS5B Polymerase Inhibitors

Sofosbuvir is an NS5B polymerase inhibitor.
Sofosbuvir is a nucleotide analog.
It inhibits HCV NS5B RNA-dependent RNA polymerase.
The drug is activated by host cell kinases to its triphosphate form.
Sofosbuvir is administered with ribavirin and peginterferon alfa.
It can be taken with or without food.
The drug is eliminated in the urine.

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Description

This quiz covers the characteristics and functions of NS5B polymerase inhibitors, specifically Sofosbuvir, including its mechanism of action, administration, and elimination. Learn about the treatment of HCV and its related compounds.Brush up on your pharmacology knowledge and take this quiz!