Questions and Answers
What drug class is Metoclopramide (Reglan)?
What is the MOA of Metoclopramide (Reglan)?
Reduces gastric fluid volume by stimulating upper GI motility via dopamine antagonism and increases tone of the valve between the esophagus and the stomach.
What are the indications for using Metoclopramide (Reglan)?
Severe nausea, vomiting, and gastroesophageal reflux.
What are contraindications for using Metoclopramide (Reglan)?
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What are the precautions when using Metoclopramide (Reglan)?
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What are the side effects when using Metoclopramide (Reglan)?
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What are the interactions when using Metoclopramide (Reglan)?
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What is the dosage and route of administration for Metoclopramide (Reglan)?
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Study Notes
Metoclopramide (Reglan) Overview
- Drug Class: Antiemetic
Mechanism of Action
- Reduces gastric fluid volume by stimulating upper gastrointestinal motility through dopamine antagonism.
- Increases the tone of the lower esophageal sphincter to minimize gastroesophageal reflux.
Indications
- Effective for treating severe nausea and vomiting.
- Used in managing gastroesophageal reflux disease (GERD).
Contraindications
- Not recommended for individuals with hypersensitivity to the drug.
- Avoid in patients with gastrointestinal bleeding, bowel obstruction, or perforation.
Precautions
- May impair mental and physical capabilities; caution advised in operating machinery or driving.
- Risk of extrapyramidal symptoms; diphenhydramine should be available for management.
Side Effects
- Common side effects include drowsiness, fatigue, sedation, and dizziness.
- Other potential effects: mental depression, hypertension, hypotension, tachycardia, bradycardia, and diarrhea.
Drug Interactions
- Can interact with atropine.
- May enhance the sedative effects of narcotics, hypnotics, and alcohol.
- Increased risk of hypertension when used concurrently with monoamine oxidase inhibitors (MAOIs).
Dosage and Administration
- Standard dosage: 10-20 mg intramuscularly (IM).
- For severe nausea/vomiting: 10 mg slow intravenous (IV) push over 1-2 minutes (preferred for rapid effect).
- Alternative option: 10 mg diluted in 50 ml normal saline, administered over 15 minutes.
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Description
Test your knowledge on Metoclopramide (Reglan) with this flashcard quiz. Explore its drug class, mechanism of action, and indications. Ideal for students studying pharmacology or healthcare professionals.
