Y1S2 001 III Pharmacology: Drug Absorption and Metabolism
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Questions and Answers

What is the primary focus of pharmacokinetics in the study of drugs?

  • The interaction between different drugs and their side effects
  • The diagnosis, prevention or treatment of a disease
  • The effect of the body on the drug (correct)
  • The effects of the drugs on the body and their mechanism of action

    • Which route of drug administration involves passage of the drug across the intestinal epithelium?

  • Parenteral
  • Intraperitoneal
  • Enteral (correct)
  • Intrathecal

    • What is the primary reason for the effective absorption of drugs through the enteral route?

  • The acidic environment of the stomach
  • The presence of protein molecules in the membrane
  • The large surface area of the gastrointestinal tract (correct)
  • The phospholipid bilayer structure of the membrane

    • What is the process by which a drug enters the bloodstream from the site of administration?

    <p>Absorption</p> Signup and view all the answers

    Which of the following is NOT a type of parenteral administration?

    <p>Sublingual</p> Signup and view all the answers

    What is the term for the study of drugs and their interactions with the living systems?

    <p>Pharmacology</p> Signup and view all the answers

    What percentage of a drug administered intravenously is available in the bloodstream?

    <p>100%</p> Signup and view all the answers

    What is the process by which the drug is broken down in the body?

    <p>Metabolism</p> Signup and view all the answers

    What is the term for the metabolism of a drug during its passage from the site of absorption to the systemic circulation?

    <p>First pass metabolism</p> Signup and view all the answers

    What is the circulation of substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte, and transport back to the liver?

    <p>Enterohepatic circulation</p> Signup and view all the answers

    Which route of administration results in the lowest bioavailability of a drug?

    <p>Oral</p> Signup and view all the answers

    What is the dispersal of drugs from the systemic circulation to the other tissues and the site of action?

    <p>Distribution</p> Signup and view all the answers

    Which type of drugs primarily binds to alpha-acid glycoprotein?

    <p>Basic drugs</p> Signup and view all the answers

    What is the primary effect of protein binding on the duration of a drug's action?

    <p>It prolongs the duration of the drug's action</p> Signup and view all the answers

    What is the primary characteristic of drugs that can cross the blood-brain barrier?

    <p>Lipid solubility and unionization</p> Signup and view all the answers

    What is the volume of distribution of a drug?

    <p>The extent of drug distribution in the body compared to plasma</p> Signup and view all the answers

    Which type of drugs is most likely to cross the placental barrier?

    <p>Lipid soluble unionized drugs</p> Signup and view all the answers

    What is the only form of a drug available for action, metabolism, and excretion?

    <p>The free and unbound fraction of the drug</p> Signup and view all the answers

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