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Questions and Answers
What is the consequence of increased absorption of a drug on its plasma concentration and toxicity?
Increased plasma concentration and toxicity
What is the effect of rifampicin on P-glycoprotein, a drug efflux pump?
Induction of P-glycoprotein
How does inhibition of P-glycoprotein affect the efflux of a drug?
Decreased efflux of the drug
What is the consequence of drug-induced mucosal damage on gastrointestinal absorption?
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How does increased plasma protein binding affect the distribution of a drug?
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Study Notes
Factors Affecting Drug Absorption
- Decreased absorption of acidic drugs (e.g., ketoconazole) can occur when gastric pH is increased by antacids
- Drug-induced mucosal damage can lead to decreased absorption, as seen with antineoplastic agents
Altered Intestinal Bacterial Flora
- Antibiotics can alter intestinal bacterial flora, leading to increased absorption of certain drugs (e.g., digoxin) and potentially causing toxicity
Induction or Inhibition of P-Glycoprotein
- Rifampicin is an inducer of P-glycoprotein, a drug efflux pump that affects drug absorption
- Induction or inhibition of P-glycoprotein can impact the efficacy of certain drugs
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Description
This quiz covers the factors that influence drug absorption, including the impact of antacids and antibiotics on the absorption of certain medications. Test your knowledge of pharmacology and how these factors can affect drug efficacy.
