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Questions and Answers
What is the consequence of increased absorption of a drug on its plasma concentration and toxicity?
What is the consequence of increased absorption of a drug on its plasma concentration and toxicity?
Increased plasma concentration and toxicity
What is the effect of rifampicin on P-glycoprotein, a drug efflux pump?
What is the effect of rifampicin on P-glycoprotein, a drug efflux pump?
Induction of P-glycoprotein
How does inhibition of P-glycoprotein affect the efflux of a drug?
How does inhibition of P-glycoprotein affect the efflux of a drug?
Decreased efflux of the drug
What is the consequence of drug-induced mucosal damage on gastrointestinal absorption?
What is the consequence of drug-induced mucosal damage on gastrointestinal absorption?
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How does increased plasma protein binding affect the distribution of a drug?
How does increased plasma protein binding affect the distribution of a drug?
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Study Notes
Factors Affecting Drug Absorption
- Decreased absorption of acidic drugs (e.g., ketoconazole) can occur when gastric pH is increased by antacids
- Drug-induced mucosal damage can lead to decreased absorption, as seen with antineoplastic agents
Altered Intestinal Bacterial Flora
- Antibiotics can alter intestinal bacterial flora, leading to increased absorption of certain drugs (e.g., digoxin) and potentially causing toxicity
Induction or Inhibition of P-Glycoprotein
- Rifampicin is an inducer of P-glycoprotein, a drug efflux pump that affects drug absorption
- Induction or inhibition of P-glycoprotein can impact the efficacy of certain drugs
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