Pharmacology: Permeability and Drug Absorption
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Questions and Answers

What is the permeability of membrane A to drug X?

  • 1.5 mm/sec
  • 0.5 mm/sec
  • 1 mm/sec (correct)
  • 2 mm/sec

    • Why is permeability important in drug development?

  • To predict drug toxicity
  • To predict drug solubility
  • To predict drug absorption (correct)
  • To predict drug metabolism

    • What affects diffusion through non-porous membranes?

  • Pore shape and size
  • Solute solubility (correct)
  • Polymer network
  • Solute size and diameter

    • What drives molecules to move from one region to another?

    <p>All of the above</p> Signup and view all the answers

    What is the purpose of a diffusion cell?

    <p>To contain a solvent alone</p> Signup and view all the answers

    What is the name of the device used to measure drug permeability?

    <p>Franz Diffusion Cell</p> Signup and view all the answers

    What is the purpose of the lag time in the diffusion process?

    <p>To establish a uniform concentration gradient within the membrane</p> Signup and view all the answers

    What is the direction of solute movement according to Fick's first law of diffusion?

    <p>From high concentration to low concentration</p> Signup and view all the answers

    What is the unit of measurement for the diffusion coefficient (D) in Fick's first law of diffusion?

    <p>Meter squared per second</p> Signup and view all the answers

    What is the physical barrier that separates the donor and receptor compartments?

    <p>Semi-permeable membrane</p> Signup and view all the answers

    What is the state of the concentration gradient in the steady state?

    <p>Does not change with time</p> Signup and view all the answers

    What does the flux (J) represent in Fick's first law of diffusion?

    <p>The amount of material flowing through a cross-sectional area</p> Signup and view all the answers

    What is the primary mechanism of osmotic drug release systems?

    <p>Osmotic pressure as a driving force</p> Signup and view all the answers

    Which process involves the separation of colloidal particles and macromolecules using a membrane?

    <p>Ultrafiltration</p> Signup and view all the answers

    What could significantly reduce the shelf life of a drug product?

    <p>Absorption of water vapor into the container</p> Signup and view all the answers

    Which of the following is NOT a step in the drug release process?

    <p>Ultrafiltration</p> Signup and view all the answers

    What is the primary difference between ultrafiltration and dialysis?

    <p>Use of pressure</p> Signup and view all the answers

    What is the purpose of ultrafiltration in relation to albumin and enzymes?

    <p>To purify them</p> Signup and view all the answers

    What is the driving force behind Fick's law?

    <p>Concentration gradient</p> Signup and view all the answers

    What is the effect of increasing the surface area of the membrane on the rate of diffusion?

    <p>It increases the rate of diffusion</p> Signup and view all the answers

    What is the relationship between the size of the particle and the rate of diffusion?

    <p>The rate of diffusion is inversely proportional to the size of the particle</p> Signup and view all the answers

    What is the effect of increasing the concentration difference (C1 – C2) on the rate of diffusion?

    <p>It increases the rate of diffusion</p> Signup and view all the answers

    What is the effect of increasing the temperature on the rate of diffusion?

    <p>It increases the rate of diffusion</p> Signup and view all the answers

    What is the effect of increasing the diffusion distance on the rate of diffusion?

    <p>It slows down the rate of diffusion</p> Signup and view all the answers

    What is the primary mechanism of separation in dialysis?

    <p>Based on molecular size</p> Signup and view all the answers

    Which type of diffusion occurs through the membrane lipid bilayer of cells?

    <p>Transcellular diffusion</p> Signup and view all the answers

    What is the direction of movement in facilitated diffusion?

    <p>From high to low concentration</p> Signup and view all the answers

    What is the purpose of hemodialysis in treating kidney malfunction?

    <p>To remove small molecules from the blood</p> Signup and view all the answers

    What is the role of channel proteins in facilitated diffusion?

    <p>To facilitate diffusion through the membrane</p> Signup and view all the answers

    What is an essential step for drug pharmacokinetics?

    <p>Diffusion through biologic membranes</p> Signup and view all the answers

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