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Questions and Answers
What is the primary adverse reaction associated with Biologic DMARDs mentioned in the text?
What is the primary adverse reaction associated with Biologic DMARDs mentioned in the text?
Which enzymes modulate immune cell activity by responding to inflammatory mediators?
Which enzymes modulate immune cell activity by responding to inflammatory mediators?
What laboratory parameter should be greater than 9 g/dL to start Tofacitinib therapy?
What laboratory parameter should be greater than 9 g/dL to start Tofacitinib therapy?
Which of the following agents is usually reserved for RA patients with inadequate response or intolerance to other drugs?
Which of the following agents is usually reserved for RA patients with inadequate response or intolerance to other drugs?
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What risk is associated with Tofacitinib treatment according to the text?
What risk is associated with Tofacitinib treatment according to the text?
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In which group of patients is Tofacitinib indicated for the treatment of RA?
In which group of patients is Tofacitinib indicated for the treatment of RA?
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Which proinflammatory cytokines are involved in the pathogenesis of rheumatoid arthritis?
Which proinflammatory cytokines are involved in the pathogenesis of rheumatoid arthritis?
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What is the main function of IL-1 and TNF-α when secreted by synovial macrophages?
What is the main function of IL-1 and TNF-α when secreted by synovial macrophages?
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Which group of biologic DMARDs includes abatacept and rituximab?
Which group of biologic DMARDs includes abatacept and rituximab?
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What effect have TNF-α inhibitors shown in the treatment of rheumatoid arthritis?
What effect have TNF-α inhibitors shown in the treatment of rheumatoid arthritis?
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In which condition should TNF-α inhibitors be used cautiously?
In which condition should TNF-α inhibitors be used cautiously?
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When can a clinical response be observed with TNF-α inhibitors therapy?
When can a clinical response be observed with TNF-α inhibitors therapy?
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Which type of infections are patients receiving biologic DMARDs at an increased risk for?
Which type of infections are patients receiving biologic DMARDs at an increased risk for?
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Why should live vaccinations not be administered to patients taking biologic DMARDs?
Why should live vaccinations not be administered to patients taking biologic DMARDs?
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What is the mechanism of action of Adalimumab in the treatment of RA?
What is the mechanism of action of Adalimumab in the treatment of RA?
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What is the frequency of administration for Certolizumab in patients with RA?
What is the frequency of administration for Certolizumab in patients with RA?
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Why should TNF-α inhibitors and non-TNF biologic agents not be used together?
Why should TNF-α inhibitors and non-TNF biologic agents not be used together?
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What is the role of Etanercept in the treatment of RA?
What is the role of Etanercept in the treatment of RA?
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What is the mechanism of action of Allopurinol?
What is the mechanism of action of Allopurinol?
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Which condition warrants caution when using Allopurinol?
Which condition warrants caution when using Allopurinol?
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What is the primary metabolite of Allopurinol?
What is the primary metabolite of Allopurinol?
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In which population should dosage adjustments be considered for Allopurinol?
In which population should dosage adjustments be considered for Allopurinol?
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What is the therapeutic use of Allopurinol?
What is the therapeutic use of Allopurinol?
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How is Allopurinol primarily eliminated from the body?
How is Allopurinol primarily eliminated from the body?
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What is the main characteristic of gout?
What is the main characteristic of gout?
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Which of the following is not a symptom commonly associated with acute flares of gout?
Which of the following is not a symptom commonly associated with acute flares of gout?
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What is the primary cause of hyperuricemia in gout?
What is the primary cause of hyperuricemia in gout?
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What is the main goal of most therapeutic strategies for gout?
What is the main goal of most therapeutic strategies for gout?
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What are some common triggers for acute gout attacks?
What are some common triggers for acute gout attacks?
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Which of the following is effective for managing acute gouty arthritis?
Which of the following is effective for managing acute gouty arthritis?
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What is the primary mechanism of action of colchicine?
What is the primary mechanism of action of colchicine?
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Which enzyme is responsible for the metabolism of colchicine?
Which enzyme is responsible for the metabolism of colchicine?
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What is the primary therapeutic use of colchicine in gout management?
What is the primary therapeutic use of colchicine in gout management?
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What side effect can chronic administration of colchicine lead to?
What side effect can chronic administration of colchicine lead to?
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How is colchicine primarily eliminated from the body?
How is colchicine primarily eliminated from the body?
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What is one common adverse effect associated with colchicine administration?
What is one common adverse effect associated with colchicine administration?
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Why is colchicine not frequently used for acute gouty attacks anymore?
Why is colchicine not frequently used for acute gouty attacks anymore?
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In what time frame should colchicine be administered to be effective during an acute gout attack?
In what time frame should colchicine be administered to be effective during an acute gout attack?
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What is the main consequence of colchicine binding to mitotic spindles?
What is the main consequence of colchicine binding to mitotic spindles?
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