Biologic DMARDs
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Questions and Answers

What is a common adverse effect of abatacept administration?

  • Joint pain
  • Hypertension
  • Upper respiratory infections (correct)
  • Muscle weakness

    • Which cytokine do tocilizumab and sarilumab inhibit by binding to IL-6 receptors?

  • IL-6 (correct)
  • TNF-α
  • IL-1
  • IL-8

    • How often is rituximab typically administered?

  • Every 2 weeks
  • Every 4 weeks
  • Every 24 weeks (correct)
  • Every 12 weeks

    • What is the mechanism of action of rituximab in rheumatoid arthritis?

    <p>Killing B lymphocytes via CD20 antigen binding</p> Signup and view all the answers

    Prior to rituximab infusion, what medications are administered to reduce infusion reactions?

    <p>Methylprednisolone, acetaminophen, and an antihistamine</p> Signup and view all the answers

    Which antigen does abatacept target?

    <p>CTLA-4</p> Signup and view all the answers

    How often is Golimumab administered?

    <p>Once a month</p> Signup and view all the answers

    Why is Infliximab not indicated for monotherapy?

    <p>Development of anti-infliximab antibodies and reduced efficacy</p> Signup and view all the answers

    What mechanism does Etanercept use to inhibit its target?

    <p>Neutralizes TNF-α by binding to it</p> Signup and view all the answers

    How does Abatacept reduce the inflammatory response?

    <p>By competing with CD28 for binding on CD80/CD86 protein</p> Signup and view all the answers

    Which biologic DMARD is administered as an IV infusion every 8 weeks?

    <p>Infliximab</p> Signup and view all the answers

    What side effect may Golimumab cause in the liver?

    <p>Increased hepatic enzymes</p> Signup and view all the answers

    What is the role of IL-1 and TNF-α in the pathogenesis of RA?

    <p>Degrading cartilage</p> Signup and view all the answers

    Which of the following is NOT an effect of TNF-α inhibitors in RA treatment?

    <p>Increase risk of lymphoma</p> Signup and view all the answers

    Which biologic DMARD may cause and/or worsen preexisting heart failure?

    <p>Etanercept</p> Signup and view all the answers

    When can a clinical response to TNF-α inhibitors be typically observed?

    <p>Within 2 weeks of therapy</p> Signup and view all the answers

    Which proinflammatory cytokines are involved in the pathogenesis of RA?

    <p>IL-1 and TNF-α</p> Signup and view all the answers

    What risk is associated with the use of TNF-α inhibitors according to the text?

    <p>Increased risk of cancer, including lymphoma</p> Signup and view all the answers

    What laboratory parameter needs to be greater than 9 g/dL before starting Tofacitinib therapy?

    <p>Hemoglobin concentration</p> Signup and view all the answers

    Which of the following is an adverse reaction associated with Biologic DMARDs?

    <p>Neutropenia</p> Signup and view all the answers

    What type of inhibitor is Tofacitinib in relation to Janus kinases?

    <p>Oral inhibitor</p> Signup and view all the answers

    Which medication is usually reserved for patients who have inadequate response or intolerance to other agents?

    <p>Tofacitinib</p> Signup and view all the answers

    What must be monitored during Tofacitinib therapy due to the risk for anemia?

    <p>Hemoglobin concentrations</p> Signup and view all the answers

    Which enzyme modulates immune cell activity in response to the binding of inflammatory mediators to the cellular membrane?

    <p>Janus kinase</p> Signup and view all the answers

    How does colchicine disrupt cellular functions?

    <p>By binding to tubulin</p> Signup and view all the answers

    What is the main therapeutic use of colchicine?

    <p>Alleviating acute gout pain</p> Signup and view all the answers

    How should colchicine be administered for it to be effective in an acute gout attack?

    <p>Within 36 hours of onset of attack</p> Signup and view all the answers

    Which enzyme is responsible for metabolizing colchicine?

    <p>CYP450 3A4</p> Signup and view all the answers

    What adverse effect is commonly associated with chronic colchicine administration?

    <p>Myopathy</p> Signup and view all the answers

    What is a common side effect of colchicine administration?

    <p>Nausea, vomiting, abdominal pain, and diarrhea</p> Signup and view all the answers

    What is a key difference between Febuxostat and Allopurinol in terms of renal elimination?

    <p>Febuxostat requires less adjustment in those with reduced renal function</p> Signup and view all the answers

    What adverse effect should be monitored in patients receiving Probenecid?

    <p>Anemia</p> Signup and view all the answers

    In which patients should Probenecid be avoided?

    <p>Patients with creatinine clearance less than 50 mL/min</p> Signup and view all the answers

    Why should Febuxostat be used with caution in patients with a history of heart disease or stroke?

    <p>It increases the risk of these events compared to Allopurinol</p> Signup and view all the answers

    Which medication is structurally unrelated to Allopurinol?

    <p>Febuxostat</p> Signup and view all the answers

    What type of drug is Probenecid?

    <p>Uricosuric</p> Signup and view all the answers

    What is a common adverse reaction associated with Biologic DMARDs?

    <p>Dermatologic reactions</p> Signup and view all the answers

    What is a notable risk associated with Febuxostat in comparison to Allopurinol?

    <p>Higher risk for rash and hypersensitivity reactions</p> Signup and view all the answers

    What potential adverse effect should raise concern when using Probenecid?

    <p>Anemia</p> Signup and view all the answers

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