39 Questions
What is a common adverse effect of abatacept administration?
Upper respiratory infections
Which cytokine do tocilizumab and sarilumab inhibit by binding to IL-6 receptors?
IL-6
How often is rituximab typically administered?
Every 24 weeks
What is the mechanism of action of rituximab in rheumatoid arthritis?
Killing B lymphocytes via CD20 antigen binding
Prior to rituximab infusion, what medications are administered to reduce infusion reactions?
Methylprednisolone, acetaminophen, and an antihistamine
Which antigen does abatacept target?
CTLA-4
How often is Golimumab administered?
Once a month
Why is Infliximab not indicated for monotherapy?
Development of anti-infliximab antibodies and reduced efficacy
What mechanism does Etanercept use to inhibit its target?
Neutralizes TNF-α by binding to it
How does Abatacept reduce the inflammatory response?
By competing with CD28 for binding on CD80/CD86 protein
Which biologic DMARD is administered as an IV infusion every 8 weeks?
Infliximab
What side effect may Golimumab cause in the liver?
Increased hepatic enzymes
What is the role of IL-1 and TNF-α in the pathogenesis of RA?
Degrading cartilage
Which of the following is NOT an effect of TNF-α inhibitors in RA treatment?
Increase risk of lymphoma
Which biologic DMARD may cause and/or worsen preexisting heart failure?
Etanercept
When can a clinical response to TNF-α inhibitors be typically observed?
Within 2 weeks of therapy
Which proinflammatory cytokines are involved in the pathogenesis of RA?
IL-1 and TNF-α
What risk is associated with the use of TNF-α inhibitors according to the text?
Increased risk of cancer, including lymphoma
What laboratory parameter needs to be greater than 9 g/dL before starting Tofacitinib therapy?
Hemoglobin concentration
Which of the following is an adverse reaction associated with Biologic DMARDs?
Neutropenia
What type of inhibitor is Tofacitinib in relation to Janus kinases?
Oral inhibitor
Which medication is usually reserved for patients who have inadequate response or intolerance to other agents?
Tofacitinib
What must be monitored during Tofacitinib therapy due to the risk for anemia?
Hemoglobin concentrations
Which enzyme modulates immune cell activity in response to the binding of inflammatory mediators to the cellular membrane?
Janus kinase
How does colchicine disrupt cellular functions?
By binding to tubulin
What is the main therapeutic use of colchicine?
Alleviating acute gout pain
How should colchicine be administered for it to be effective in an acute gout attack?
Within 36 hours of onset of attack
Which enzyme is responsible for metabolizing colchicine?
CYP450 3A4
What adverse effect is commonly associated with chronic colchicine administration?
Myopathy
What is a common side effect of colchicine administration?
Nausea, vomiting, abdominal pain, and diarrhea
What is a key difference between Febuxostat and Allopurinol in terms of renal elimination?
Febuxostat requires less adjustment in those with reduced renal function
What adverse effect should be monitored in patients receiving Probenecid?
Anemia
In which patients should Probenecid be avoided?
Patients with creatinine clearance less than 50 mL/min
Why should Febuxostat be used with caution in patients with a history of heart disease or stroke?
It increases the risk of these events compared to Allopurinol
Which medication is structurally unrelated to Allopurinol?
Febuxostat
What type of drug is Probenecid?
Uricosuric
What is a common adverse reaction associated with Biologic DMARDs?
Dermatologic reactions
What is a notable risk associated with Febuxostat in comparison to Allopurinol?
Higher risk for rash and hypersensitivity reactions
What potential adverse effect should raise concern when using Probenecid?
Anemia
This quiz covers topics related to Biologic DMARDs in pharmacology, including Glucocorticoids, Adalimumab, Certolizumab, Etanercept, Golimumab, Infliximab, Abatacept, Rituximab, Tocilizumab, sarilumab, and other drugs used for treating rheumatoid arthritis and gout.
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