Podcast
Questions and Answers
What is a common adverse effect of abatacept administration?
What is a common adverse effect of abatacept administration?
- Joint pain
- Hypertension
- Upper respiratory infections (correct)
- Muscle weakness
Which cytokine do tocilizumab and sarilumab inhibit by binding to IL-6 receptors?
Which cytokine do tocilizumab and sarilumab inhibit by binding to IL-6 receptors?
- IL-6 (correct)
- TNF-α
- IL-1
- IL-8
How often is rituximab typically administered?
How often is rituximab typically administered?
- Every 2 weeks
- Every 4 weeks
- Every 24 weeks (correct)
- Every 12 weeks
What is the mechanism of action of rituximab in rheumatoid arthritis?
What is the mechanism of action of rituximab in rheumatoid arthritis?
Prior to rituximab infusion, what medications are administered to reduce infusion reactions?
Prior to rituximab infusion, what medications are administered to reduce infusion reactions?
Which antigen does abatacept target?
Which antigen does abatacept target?
How often is Golimumab administered?
How often is Golimumab administered?
Why is Infliximab not indicated for monotherapy?
Why is Infliximab not indicated for monotherapy?
What mechanism does Etanercept use to inhibit its target?
What mechanism does Etanercept use to inhibit its target?
How does Abatacept reduce the inflammatory response?
How does Abatacept reduce the inflammatory response?
Which biologic DMARD is administered as an IV infusion every 8 weeks?
Which biologic DMARD is administered as an IV infusion every 8 weeks?
What side effect may Golimumab cause in the liver?
What side effect may Golimumab cause in the liver?
What is the role of IL-1 and TNF-α in the pathogenesis of RA?
What is the role of IL-1 and TNF-α in the pathogenesis of RA?
Which of the following is NOT an effect of TNF-α inhibitors in RA treatment?
Which of the following is NOT an effect of TNF-α inhibitors in RA treatment?
Which biologic DMARD may cause and/or worsen preexisting heart failure?
Which biologic DMARD may cause and/or worsen preexisting heart failure?
When can a clinical response to TNF-α inhibitors be typically observed?
When can a clinical response to TNF-α inhibitors be typically observed?
Which proinflammatory cytokines are involved in the pathogenesis of RA?
Which proinflammatory cytokines are involved in the pathogenesis of RA?
What risk is associated with the use of TNF-α inhibitors according to the text?
What risk is associated with the use of TNF-α inhibitors according to the text?
What laboratory parameter needs to be greater than 9 g/dL before starting Tofacitinib therapy?
What laboratory parameter needs to be greater than 9 g/dL before starting Tofacitinib therapy?
Which of the following is an adverse reaction associated with Biologic DMARDs?
Which of the following is an adverse reaction associated with Biologic DMARDs?
What type of inhibitor is Tofacitinib in relation to Janus kinases?
What type of inhibitor is Tofacitinib in relation to Janus kinases?
Which medication is usually reserved for patients who have inadequate response or intolerance to other agents?
Which medication is usually reserved for patients who have inadequate response or intolerance to other agents?
What must be monitored during Tofacitinib therapy due to the risk for anemia?
What must be monitored during Tofacitinib therapy due to the risk for anemia?
Which enzyme modulates immune cell activity in response to the binding of inflammatory mediators to the cellular membrane?
Which enzyme modulates immune cell activity in response to the binding of inflammatory mediators to the cellular membrane?
How does colchicine disrupt cellular functions?
How does colchicine disrupt cellular functions?
What is the main therapeutic use of colchicine?
What is the main therapeutic use of colchicine?
How should colchicine be administered for it to be effective in an acute gout attack?
How should colchicine be administered for it to be effective in an acute gout attack?
Which enzyme is responsible for metabolizing colchicine?
Which enzyme is responsible for metabolizing colchicine?
What adverse effect is commonly associated with chronic colchicine administration?
What adverse effect is commonly associated with chronic colchicine administration?
What is a common side effect of colchicine administration?
What is a common side effect of colchicine administration?
What is a key difference between Febuxostat and Allopurinol in terms of renal elimination?
What is a key difference between Febuxostat and Allopurinol in terms of renal elimination?
What adverse effect should be monitored in patients receiving Probenecid?
What adverse effect should be monitored in patients receiving Probenecid?
In which patients should Probenecid be avoided?
In which patients should Probenecid be avoided?
Why should Febuxostat be used with caution in patients with a history of heart disease or stroke?
Why should Febuxostat be used with caution in patients with a history of heart disease or stroke?
Which medication is structurally unrelated to Allopurinol?
Which medication is structurally unrelated to Allopurinol?
What type of drug is Probenecid?
What type of drug is Probenecid?
What is a common adverse reaction associated with Biologic DMARDs?
What is a common adverse reaction associated with Biologic DMARDs?
What is a notable risk associated with Febuxostat in comparison to Allopurinol?
What is a notable risk associated with Febuxostat in comparison to Allopurinol?
What potential adverse effect should raise concern when using Probenecid?
What potential adverse effect should raise concern when using Probenecid?
